An Analysis of the Relationship Between Metabolism, Developmental Schedules, and Longevity Using Phylogenetic Independent Contrasts

Magalhães, João Pedro de; Costa, Joana S.; Church, George M.

doi:10.1093/gerona/62.2.149

Cited by 342 publications

(410 citation statements)

References 47 publications

(126 reference statements)

Supporting

Mentioning

368

Contrasting

Order By: Relevance

“…The association of methionine enrichment with decreasing lifespan also remained significant after mathematical correction for body mass, a potentially confounding factor known to correlate with lifespan (Speakman, 2005;de Magalhã es et al, 2007). To reach this conclusion, we calculated the partial correlation coefficient between methionine abundance and longevity controlling for body mass either with (n = 167, r = )0.165, P = 0.017) or without (n = 168, r = )0.263, P = 0.0003) phylogenetic correction (Fig.…”

Section: Resultsmentioning

confidence: 97%

Mitochondrially encoded methionine is inversely related to longevity in mammals

Aledo

Magalhães

et al. 2010

Aging Cell

View full text Add to dashboard Cite

SummaryMethionine residues in proteins react readily with reactive oxygen species making them particularly sensitive to oxidation. However, because oxidized methionine can be reduced back in a catalyzed reaction, it has been suggested that methionine residues act as oxidant scavengers, protecting not only the proteins where they are located but also the surrounding macromolecules. To investigate whether methionine residues may be selected for or against animal longevity, we carried out a metaexamination of mitochondrial genomes from mammalian species. Our analyses unveiled a hitherto unnoticed observation: mitochondrially encoded polypeptides from short-lived species are enriched in methionine when compared with their long-lived counterparts. We show evidence suggesting that methionine addition to proteins in short-lived species, rather than methionine loss from proteins in long-lived species, is behind the reported difference in methionine usage. The inverse association between longevity and methionine, which persisted after correction for body mass and phylogenetic interdependence, was paralleled by the methionine codon AUA, but not by the codon AUG. Although nuclear encoded mitochondrial polypeptides exhibited higher methionine usage than nonmitochondrial proteins, correlation with longevity was only found within the group of those polypeptides located in the inner mitochondrial membrane.Based on these results, we propose that short-lived animals subjected to higher oxidative stress selectively accumulate methionine in their mitochondrially encoded proteins, which supports the role of oxidative damage in aging.

show abstract

Section: Resultsmentioning

confidence: 97%

Mitochondrially encoded methionine is inversely related to longevity in mammals

Aledo

Magalhães

et al. 2010

Aging Cell

View full text Add to dashboard Cite

show abstract

“…[3,5,6]). However, our study is the first, to our knowledge, to demonstrate the general importance of body size in both volant and non-volant species concurrently (as opposed to traditional taxonomic groupings of birds, bats and terrestrial mammals separately).…”

Section: Discussionmentioning

confidence: 99%

“…We used maximum longevity as our measure of lifespan as it is thought to be the best available estimator of a species' ageing rate [5] and because of the amount of high-quality longevity data available. We obtained data on maximum longevity (years) and adult body mass (g) from the AnAge database [1,22].…”

Section: Materials and Methods (A) Datamentioning

confidence: 99%

Ecology and mode-of-life explain lifespan variation in birds and mammals

et al. 2014

View full text Add to dashboard Cite

Maximum lifespan in birds and mammals varies strongly with body mass such that large species tend to live longer than smaller species. However, many species live far longer than expected given their body mass. This may reflect interspecific variation in extrinsic mortality, as life-history theory predicts investment in long-term survival is under positive selection when extrinsic mortality is reduced. Here, we investigate how multiple ecological and mode-of-life traits that should reduce extrinsic mortality (including volancy (flight capability), activity period, foraging environment and fossoriality), simultaneously influence lifespan across endotherms. Using novel phylogenetic comparative analyses and to our knowledge, the most species analysed to date (n ¼ 1368), we show that, over and above the effect of body mass, the most important factor enabling longer lifespan is the ability to fly. Within volant species, lifespan depended upon when (day, night, dusk or dawn), but not where (in the air, in trees or on the ground), species are active. However, the opposite was true for non-volant species, where lifespan correlated positively with both arboreality and fossoriality. Our results highlight that when studying the molecular basis behind cellular processes such as those underlying lifespan, it is important to consider the ecological selection pressures that shaped them over evolutionary time.

show abstract

“…Therefore, one hypothesis to explain the exceptional lifespan potential observed in Heterocephalus glaber (naked mole-rats) is fossoriality [1,8,[11][12][13]. Alternatively, social factors may play a primary role in Heterocephalus longevity [4,5].…”

mentioning

confidence: 99%