Land subsidence usually bears strong relationship to abstraction of underground fluid. Land subsidence occurs commonly in the North China Plain (NCP) and has become a major environmental factor hindering regional sustainable development. This paper focuses on issues associated with mechanism of land subsidence in the NCP. The analysis shows that multi-layer aquifer systems with deep confined aquifers and the thick normally consolidated or unconsolidated compressible clay layers are the key of geological and hydrogeological conditions favorable for the development of land subsidence in the NCP. Groundwater withdrawal results in an increase in the distribution of effective stress within the strata and the compression of the aquifers and the confining layers, and then triggers land subsidence. In the middle-east plain of the NCP, the land subsidence volume approximately represents the amount of water released from compression of deep aquifers and aquitards in that land subsidence is primarily caused by excessive groundwater withdrawal in deep aquifer system. The percentage of water released from compression of aquifers and aquitards in deep groundwater abstraction is significant but distinct in Cangzhou City and in the whole middle-east plain. This is due to the difference in local lithological structure and recharge and discharge conditions of deep groundwater system. The hysteresis of land subsidence is also discussed in typical areas and the results reveal that the time for completing the primary consolidation ranges from less than one year to tens of years, and that the rate of secondary compression tends to increase with the moisture content.