An Analysis of Weight Gains and Body Mass Index in Patients with Barrett’s Esophagus

Nathanson, Brian H.; Navab, Farhad

doi:10.1016/j.jand.2016.03.009

Cited by 4 publications

(2 citation statements)

References 43 publications

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“…We found that the 10 year OS of patients with a high BMI were significantly longer than patients with a low BMI, which was true for both the entire cohort and the ESCC group. This result was consistent with previous studies in both benign tumors22–25 and malignant tumors 12,26–33. Although there have been studies that investigated the relationship between esophageal cancer and BMI,12,16,34–39 these studies primarily focused on operative squamous cell carcinoma, esophageal adenocarcinoma, or patients only treated with adjuvant therapy.…”

Section: Discussionsupporting

confidence: 92%

<p>Prognostic significance of combined pretreatment body mass index (BMI) and BMI loss in patients with esophageal cancer</p>

Gu¹,

Fang²,

Liu³

et al. 2019

CMAR

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Background: Body mass index (BMI) has been associated with a risk of esophageal cancer. However, the influence of BMI and BMI loss on people with esophageal cancer that were treated with different therapies has not been described in China. Methods: In total, 615 consecutive patients that underwent esophagectomy and/or chemotherapy/radiotherapy were classified according to the Asian-specific BMI (kg/m 2 ) cutoff values. The impact of BMI and BMI loss on long-term overall survival (OS) was estimated using the Kaplan–Meier method and Cox proportional hazard models. Results: Multivariate analysis showed that overweight and obese patients had a more favorable survival than normal weight and underweight patients ( p =0.017). Patients with a low BMI and high BMI loss before therapy had worse OS than others ( p =0.001). Subgroup analysis showed that patients with a high BMI were more likely to suffer hypertension ( p <0.001) and receive only surgery ( p <0.001), and they were less likely to be smokers ( p =0.007) and anemic ( p <0.001). Conversely, patients with high BMI loss were more likely to be anemic ( p =0.001), to have advanced pathological stage ( p =0.012), and to receive chemotherapy and radiotherapy ( p =0.001). Moreover, the mortality rate was higher when patients had a high BMI loss. There is no survival benefit of higher BMI in the non-esophageal squamous cell carcinoma (ESCC) group. Conclusion: Pretreatment BMI was an independent prognostic factor for long-term survival in esophageal cancer patients treated with different treatments. The overall survival was increased in esophageal cancer patients with a high pretreatment BMI and no BMI loss. There is no survival benefit of higher BMI in the non-ESCC group.

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Section: Discussionsupporting

confidence: 92%

<p>Prognostic significance of combined pretreatment body mass index (BMI) and BMI loss in patients with esophageal cancer</p>

Gu¹,

Fang²,

Liu³

et al. 2019

CMAR

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“…Another recent study indicated that breaking up prolonged sitting with standing or walking attenuated postprandial metabolic response in postmenopausal women. Furthermore, late-night dinner and bedtime snacking are associated with several health problems including gastroesophageal reflux disease and chronic kidney disease . We suggest that in the study by Martin et al calorie restriction might have theoretically led to several healthy behaviors, including shorter sitting periods for eating, slower eating speed, lower rates of eating until full, and lower rates of night snacking.…”

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confidence: 99%

Healthy Behaviors Potentially Due to Calorie Restriction

2016

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To the Editor We read with interest the Original Investigation by Martin et al 1 in a recent issue of JAMA Internal Medicine suggesting that calorie restriction leads to significant benefits on mood, quality of life, sexual function, and sleep quality. The findings of this well-designed study suggest that intake of excess calories is not only a burden to our physical homeostasis but also on our psychological well-being. One previous study 2 indicated that, in addition to eating quickly, eating until full was associated with being overweight. Another recent study 3 indicated that breaking up prolonged sitting with standing or walking attenuated postprandial metabolic response in postmenopausal women. Furthermore, late-night dinner and bedtime snacking are associated with several health problems including gastroesophageal reflux disease and chronic kidney disease. 4,5 We suggest that in the study by Martin et al 1 calorie restriction might have theoretically led to several healthy behaviors, including shorter sitting periods for eating, slower eating speed, lower rates of eating until full, and lower rates of night snacking. We wonder if the authors did specific analyses in their study, which has a very detailed and comprehensive protocol.

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Dietary Habits and Risk of Esophagitis and Barrett’s Esophagus: A Multicenter Italian Case–Control Study

et al. 2020

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An Analysis of Weight Gains and Body Mass Index in Patients with Barrett’s Esophagus

Cited by 4 publications

References 43 publications

<p>Prognostic significance of combined pretreatment body mass index (BMI) and BMI loss in patients with esophageal cancer</p>

<p>Prognostic significance of combined pretreatment body mass index (BMI) and BMI loss in patients with esophageal cancer</p>

Healthy Behaviors Potentially Due to Calorie Restriction

Dietary Habits and Risk of Esophagitis and Barrett’s Esophagus: A Multicenter Italian Case–Control Study

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