An analytical review of silicone immunology

Marcus, Donald M.

doi:10.1002/art.1780391003

Cited by 22 publications

(3 citation statements)

References 66 publications

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“…Consequently, numerous environmental and toxicological studies [12][13][14][15][16][17][18][19] were undertaken. Several of the studies were mandated by government interest, while others were initiated by silicone producers as part of their commitment to good product stewardship.…”

Section: Introductionmentioning

confidence: 99%

A Primer on the Analytical Aspects of Silicones at Trace Levels-Challenges and Artifacts – A Review

2006

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Silicones (polydimethylsiloxanes) find use in a wide variety of industrial and consumer product applications because of their outstanding properties. Potential human exposure to silicones occurs in the work place during manufacturing and product formulation, as well as through the normal use of consumer products containing them.The entry of silicones into various environmental compartments raised health and safety concerns from potential exposure and mandated numerous environmental and toxicological studies. Such studies require qualitative and quantitative determination of silicone species at trace levels. However, the ubiquitous presence of silicones coupled with their unique chemistry renders their analysis at trace levels challenging.This paper provides a consolidated account of various aspects of silicones that must be borne in mind to obtain reliable data. The following topics are discussed: differences in the chemistry of silicones vs carbon; precautions in sample handling to avoid losses and inadvertent chemical transformation; potential sources for artifacts and interferences that could lead to systematic errors and data misinterpretation; sources for background and the need for matrix matched blank experiments; distinguishing silicones from silicates to avoid overestimation; potential for incorrect structural assignments; preventing inadvertent contamination; and questionable claims on the presence of silicones in biological matrices including that of silicone implants.

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Section: Introductionmentioning

confidence: 99%

A Primer on the Analytical Aspects of Silicones at Trace Levels-Challenges and Artifacts – A Review

2006

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“…Chen et al 2014 (31), reported a case of acute urticaria associated with Mirena ® implantation, while both Pereira and Coker 2003, (32) and Karry et al 2006 (33) reported cases of acute dermatitis related to application of Mirena ® . No one of the authors analyzed sensitization to specific components of this type of IUDs, but according to the literature data all components of Mirena ® possess hypersensitivity potential (34,35,36,37).…”

Section: Gynecological Devicesmentioning

confidence: 99%

Hypersensitivity Potential of Gynecological Devices

Vukelić-Nikolić¹,

Popović²,

Djordjević³

et al. 2019

amm

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Medical devices encompass an extremely wide range of products used in variety of settings for the diagnosis, prevention, monitoring or treatment of illness or disability. Development of medicine and technology causes constantly increasing number of different medical devices with characteristics corresponding to biomaterials and whose application can lead to development of hypersensitivity reactions. Despite the fact that gynecology is a wide field for biomaterials applications, there are no summarized data about hypersensitivity reactions to gynecological devices. This paper gives an overview of hypersensitivity potential and common clinical manifestations of medical devices that are specifically used in gynecology. Summarizing these data is very important for improvement of current medical practice and also for designing and creating new medical devices.

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“…As silicone has a long history as a biomaterial, its safety has been carefully investigated. Nevertheless, some of research works, specifically those that focused on implanted silicone prostheses, suggest that silicone is an adjuvant to the human immune system and may induce conformational changes and aggregation of proteins . Furthermore, patients with silicone prostheses display a variety of nonspecific syndromes that usually disappear after removal of the implant .…”

Section: Introductionmentioning

confidence: 99%

Effect of Silicone on the Collagen Fibrillogenesis and Stability

Kadziński

Prokopowicz

Jakóbkiewicz‐Banecka

et al. 2015

Journal of Pharmaceutical Sciences

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Collagen, the most abundant protein in mammals, is able to form fibrils, which have central role in tissue repair, fibrosis, and tumor invasion. As a component of skin, tendons, and cartilages, this protein contacts with any implanted materials. An inherent problem associated with implanted prostheses is their propensity to be coated with host proteins shortly after implantation. Also, silicone implants undergoing relatively long periods of contact with blood can lead to formation of thrombi and emboli. In this paper, we demonstrate the existence of interactions between siloxanes and collagen. Low-molecular-weight cyclic siloxane (hexamethylcyclotrisiloxane—D3) and polydimethylsiloxanes (PDMS) forming linear chains, ranging in viscosity from 20 to 12,000 cSt, were analyzed. We show that D3 as well as short-chain PDMS interact with collagen, resulting in a decrease in fibrillogenesis. However, loss of collagen native structure does not occur because of these interactions. Rather, collagen seems to be sequestered in its native form in an interlayer formed by collagen–siloxane complexes. On the other hand, silicone molecules with longer chains (i.e., PDMS with viscosity of 1000 and 12,000 cSt, the highest viscosity analyzed here) demonstrate little interaction with this protein and do not seem to affect collagen activity. © 2015 Wiley Periodicals, Inc. and the American Pharmacists Association J Pharm Sci 104:1275–1281, 2015

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An analytical review of silicone immunology

Cited by 22 publications

References 66 publications

A Primer on the Analytical Aspects of Silicones at Trace Levels-Challenges and Artifacts – A Review

A Primer on the Analytical Aspects of Silicones at Trace Levels-Challenges and Artifacts – A Review

Hypersensitivity Potential of Gynecological Devices

Effect of Silicone on the Collagen Fibrillogenesis and Stability

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