This study provides a numerical approach to investigate radial flow through a single rough-walled fracture. To facilitate the size-dependency investigation, rough-walled fractures as large as 18 m were generated by using tiny cubes to mimic fracture asperities. Subsequently, a two-dimensional Reynolds equation was solved to simulate radial flow through the rough fractures with various fracture apertures and roughness values. The impact of normal stress on the hydraulic properties was incorporated by using a hyperbolic function. The results show clear evidence for size dependence of hydraulic conductivity. In particular, the hydraulic conductivity globally increases with increasing fracture radius until a given size, which if exceeded causes the hydraulic conductivity to approach an asymptotic value. Therefore, the given size can be considered as the representative size, which is determined to be a radius ranging from 12 to 17 m, attributing to the variations in fracture aperture, roughness and normal stress. It was also found that the representative size decreases with an increment in the fracture aperture; this tends to increase as the fracture roughness or the normal stress increases, since those factors will more or less alter the fracture topology and contact areas, which play a key role in controlling the tortuosity and connectivity of radial flow through a rough fracture. This article gives some insight into size dependence of radial flow through a single rough fracture and places an emphasis on the representative size, which, when it does exist, must be identified before correlating the laboratory-scale investigations to in-situ applications.