An Analytical Spectrophotometric Study to Determine Paracetamol and Diclofenac Sodium in Pharmaceutical Formulations

Antakli, Saad; Nejem, Leon; Soufan, Kamar

doi:10.5958/0974-360x.2018.00545.0

Cited by 2 publications

(2 citation statements)

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“…Table 2 shows the comparison techniques used for the simultaneous determination of PA and DF. It can be summarized that the DPAdSV with SPCE/MWCNTs-COOH allows the lowest LOD value to be obtained compared with all other electrochemical sensors and techniques [ 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 ].…”

Section: Resultsmentioning

confidence: 99%

“…There are many methods in the literature describing the simultaneous analysis of PA and DF. These are chromatographic methods based on high performance liquid chromatography [ 9 , 10 , 11 , 12 ] and gas chromatography with mass spectroscopy [ 13 ], as well as spectrophotometry [ 14 ] and electrophoresis [ 15 , 16 ]. However, these methods usually require a time- and reagent-consuming step of sample preparation process for determination of low concentration of PA and DF in samples.…”

Section: Introductionmentioning

confidence: 99%

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Simultaneous Analysis of Paracetamol and Diclofenac Using MWCNTs-COOH Modified Screen-Printed Carbon Electrode and Pulsed Potential Accumulation

et al. 2020

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A differential-pulse adsorptive stripping voltammetric (DPAdSV) procedure with the use of pulsed potential accumulation and carboxyl functionalized multiwalled carbon nanotubes modified screen-printed carbon electrode (SPCE/MWCNTs-COOH) was delineated for simultaneous analysis of paracetamol (PA) and diclofenac (DF). The use of carboxyl functionalized MWCNTs and pulsed potential accumulation improves the analytical signals of PA and DF, and minimizes interferences from surfactants. After optimization of analytical conditions for this sensor, the peak currents of the two compounds were found to increase linearly with the increase in their concentration (5.0 × 10−9–5.0 × 10−6 mol L−1 with a detection limit of 1.4 × 10−9 mol L−1 for PA, and 1.0 × 10−10–2.0 × 10−8 mol L−1 with a detection limit of 3.0 × 10−11 mol L−1 for DF). For the first time, the electrochemical sensor allows simultaneous determination of PA and DF at concentrations of 24.3 ± 0.5 nmol L−1 and 3.7 ± 0.7 nmol L−1, respectively, in wastewater samples purified in a sewage treatment plant.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Simultaneous Analysis of Paracetamol and Diclofenac Using MWCNTs-COOH Modified Screen-Printed Carbon Electrode and Pulsed Potential Accumulation

et al. 2020

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A Review of various Analytical Methods Developed for Estimation of Paracetamol, Diclofenac sodium, and Chlorzoxazone in Single-component and Multi-component Dosage Form

Doma Sherpa,

Pandit,

Shrestha

2023

RJPT

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Painful muco-skeletal joint disorders such as osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis are typically treated with a combination of paracetamol, diclofenac sodium, and chlorzoxazone. Paracetamol and diclofenac sodium are non-steroidal anti-inflammatory drugs, while chlorzoxazone is a muscle relaxant. It acts on the central nervous system and the spinal cord to reduce muscle stiffness and spasms as well as increase muscle mobility. The most commonly used pharmaceutical medicine is paracetamol, which comes in a variety of dosage forms such as injection, tablet, capsule, drops, elixirs, suspensions, and suppositories. However, due to toxicity, it may cause mortality in large dosages with extended intake. As a result, more efficient analytical approaches aimed at providing quality control of routinely used medications are required. Numerous analytical methods, both spectroscopic and chromatographic such as high-performance liquid chromatography, gas chromatography with mass spectrometry, and high-performance thin-layer chromatography have been established to estimate paracetamol diclofenac sodium and chlorzoxazone in their single-component dosage form. The simultaneous estimation of paracetamol, diclofenac sodium, and chlorzoxazone in combined dosage forms has been performed using reverse-phase high-performance liquid chromatography and high-performance thin-layer chromatography techniques. In contrast, there are very few techniques available to estimate paracetamol, diclofenac sodium, and chlorzoxazone in combination pharmaceutical dose form till date. This article is an attempt to jut out all the methods developed to estimate the above-mentioned drugs in the single or multi-component dosage form.

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An Analytical Spectrophotometric Study to Determine Paracetamol and Diclofenac Sodium in Pharmaceutical Formulations

Cited by 2 publications

References 0 publications

Simultaneous Analysis of Paracetamol and Diclofenac Using MWCNTs-COOH Modified Screen-Printed Carbon Electrode and Pulsed Potential Accumulation

Simultaneous Analysis of Paracetamol and Diclofenac Using MWCNTs-COOH Modified Screen-Printed Carbon Electrode and Pulsed Potential Accumulation

A Review of various Analytical Methods Developed for Estimation of Paracetamol, Diclofenac sodium, and Chlorzoxazone in Single-component and Multi-component Dosage Form

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