2022
DOI: 10.1080/09546634.2022.2116924
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An anchored matching-adjusted indirect comparison of fixed-dose combination calcipotriol and betamethasone dipropionate (Cal/BDP) cream versus Cal/BDP foam for the treatment of psoriasis

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Cited by 7 publications
(7 citation statements)
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“…In the absence of head-to-head RCTs, two MAIC analyses were recently undertaken to evaluate the efficacy of the Cal/BD cream versus the Cal/BD foam when used for the recommended treatment duration (8 weeks for cream and 4 weeks for foam) [ 46 , 47 ]. The analysis by Bewley and collaborators reported comparable effectiveness (i.e., no statistically significant difference) at the recommended treatment durations for cream and foam [ 46 ].…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…In the absence of head-to-head RCTs, two MAIC analyses were recently undertaken to evaluate the efficacy of the Cal/BD cream versus the Cal/BD foam when used for the recommended treatment duration (8 weeks for cream and 4 weeks for foam) [ 46 , 47 ]. The analysis by Bewley and collaborators reported comparable effectiveness (i.e., no statistically significant difference) at the recommended treatment durations for cream and foam [ 46 ].…”
Section: Discussionmentioning
confidence: 99%
“…In the absence of head-to-head RCTs, two MAIC analyses were recently undertaken to evaluate the efficacy of the Cal/BD cream versus the Cal/BD foam when used for the recommended treatment duration (8 weeks for cream and 4 weeks for foam) [ 46 , 47 ]. The analysis by Bewley and collaborators reported comparable effectiveness (i.e., no statistically significant difference) at the recommended treatment durations for cream and foam [ 46 ]. However, a MAIC analysis of five different trials by Papp et al consistently showed that Cal/BD foam treatment for 4 weeks induced a significantly higher PGA success than 8 weeks of the Cal/BD cream, with an even greater difference seen between the two formulations after 4 weeks of each treatment [ 47 ].…”
Section: Discussionmentioning
confidence: 99%
“…These indirect comparisons were conducted without the exclusion of severe patients, nor adjustment on prognostic factors such as baseline severity or the other variables listed in Tables SI-SV, as that was not possible with the Bucher's adjusted indirect comparison method employed (7). Such an adjustment is feasible with the approach detailed here (10) and in a related MAIC of Cal/ BD cream vs foam that corroborates the similar impact on QoL of the 2 approved treatments (11). Moreover, Reich et al included MAICs of DLQI 0/1 response between on-and off-label Cal/BD cream and Cal/BD foam treatments to compare the same treatment durations; the results at 4 (off-label Cal/BD cream) and 8 (off-label Cal/ BD foam) weeks numerically favoured Cal/BD cream, but the differences were insignificant (7).…”
Section: Acta Dermato-venereologicamentioning
confidence: 97%
“…These two CAL/BDP foam trials were selected as they were the only ones sharing a common comparator with the CAL/BDP PAD-cream trials, the CAL/BDP gel. The presence of this common comparator allowed for an anchored matching-adjusted indirect comparison (MAIC) to be undertaken [ 24 ].…”
Section: Clinical Evidencementioning
confidence: 99%
“…Treatment satisfaction was measured with six equivalent questions from the PTCS of CAL/BDP PAD-cream trials and the Topical Product Usability Questionnaire (TPUQ) of the PSO-INSIGHTFUL study. The comparison of treatment satisfaction outcomes could only be made after one week of treatment because, in the PSO-INSIGHTFUL study, CAL/BDP foam and CAL/BDP gel were used only for one week, and this was the only study comparing the foam and gel formulations in these satisfaction and convenience variables [ 24 ].…”
Section: Clinical Evidencementioning
confidence: 99%