An Ancient Chinese Herb Berberine; New Research in Diabetes Mellitus

Sha, Wenjun; Zhang, Weifei; Huang, Wenjin; Zhou, Mingyue; Jingjing, Niu; Jiang, Hanqiu; Li, Junyan; Li, Fufeng; Zhu, Ting; Xin, Xia; Yuan-dong, Shen; Zhou, Ligang

doi:10.5772/56950

Cited by 2 publications

(2 citation statements)

References 16 publications

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“…Berberine (BBR) is a natural alkaloid isolated from plants such as Coptischinensis, Hydrastiscanadensis and Berberis vulgarism and has long been used in Chinese medicines [ 100 ]. Many reports have indicated indicate the inhibitory effect of BBR on the production of pro-inflammatory cytokines in various cell lines including pancreatic β -cells, nerve cells, lung cells and rat kidney cells [ 101 ] and animal models of insulin resistance [ 102 ].…”

Section: Natural Pharmacological Modulatorsmentioning

confidence: 99%

Phytochemicals as modulators of M1-M2 macrophages in inflammation

Sarkar²,

et al. 2018

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Macrophages are critical mediators of the innate immune response against foreign pathogens, including bacteria, physical stress, and injury. Therefore, these cells play a key role in the “inflammatory pathway” which in turn can lead to an array of diseases and disorders such as autoimmune neuropathies and myocarditis, inflammatory bowel disease, atherosclerosis, sepsis, arthritis, diabetes, and angiogenesis. Recently, more studies have focused on the macrophages inflammatory diseases since the discovery of the two subtypes of macrophages, which are differentiated on the basis of their phenotype and distinct gene expression pattern. Of these, M1 macrophages are pro-inflammatory and responsible for inflammatory signaling, while M2 are anti-inflammatory macrophages that participate in the resolution of the inflammatory process, M2 macrophages produce anti-inflammatory cytokines, thereby contributing to tissue healing. Many studies have shown the role of these two subtypes in the inflammatory pathway, and their emergence appears to decide the fate of inflammatory signaling and disease progression. As a next step in directing the pro-inflammatory response toward the anti-inflammatory type after an insult by a foreign pathogen (e. g., bacterial lipopolysaccharide), investigators have identified many natural compounds that have the potential to modulate M1 to M2 macrophages. In this review, we provide a focused discussion of advances in the identification of natural therapeutic molecules with anti-inflammatory properties that modulate the phenotype of macrophages from M1 to M2.

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Section: Natural Pharmacological Modulatorsmentioning

confidence: 99%

Phytochemicals as modulators of M1-M2 macrophages in inflammation

Sarkar²,

et al. 2018

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“…Berberine is an isoquinoline plant alkaloid (Figure 1) that has been used for centuries in traditional Chinese medicine for its antidiabetic and anti-inflammatory properties to treat a host of disorders (Sha et al, 2013). The agent is derived from the roots, stems, rhizomes, and bark of various plants including Berberis vulgaris (barberry), Berberis aristata (tree turmeric), and Hydrastis canadensis (goldenseal) (Singh and Mahajan, 2013).…”

Section: Introductionmentioning

confidence: 99%

Variability in Potency Among Commercial Preparations of Berberine

Funk

Singh

Winefield

et al. 2017

Journal of Dietary Supplements

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Berberine is an isoquinoline alkaloid plant extract that is widely available as a dietary supplement in the United States and has demonstrated efficacy in the treatment of type 2 diabetes mellitus and dyslipidemia. Because of its increased use and purported pharmacological properties, potential variations in product quality could pose a barrier to berberine's safety and effectiveness in clinical practice. Thus, this study evaluated the potency of dietary supplements containing berberine available in the U.S. commercial market. Fifteen unique dietary supplements containing berberine were purchased through U.S. dietary supplement vendors. For each product, berberine was extracted from 3 unique capsules and analyzed by ultra-high-performance liquid chromatography tandem mass spectrometry. Percentage content based on the product label claim was determined for each product. The average berberine content across the products was found to be 75% ± 25% of the product label claim, with product potency ranging from 33% to 100%. Nine of the 15 tested products (60%) failed to meet the potency standards of 90% to 110% of labeled content claim, as commonly required of pharmaceutical preparations by the U.S. Pharmacopeial Convention. Evaluation of the relationship between product cost and the measured potency failed to demonstrate an association between quality and cost. Variability in product quality may significantly contribute to inconsistencies in the safety and effectiveness of berberine. In addition, the quality of the berberine product cannot be inferred from its cost.

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An Ancient Chinese Herb Berberine; New Research in Diabetes Mellitus

Cited by 2 publications

References 16 publications

Phytochemicals as modulators of M1-M2 macrophages in inflammation

Phytochemicals as modulators of M1-M2 macrophages in inflammation

Variability in Potency Among Commercial Preparations of Berberine

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