AN ANIMAL MODEL OF SOLAR‐AGED SKIN: HISTOLOGICAL, PHYSICAL, and VISIBLE CHANGES IN UV‐IRRADIATED HAIRLESS MOUSE SKIN*

Bissett, Donald; Hannon, Daniel P.; Orr, T. V.

doi:10.1111/j.1751-1097.1987.tb04783.x

Cited by 286 publications

(256 citation statements)

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“…Skin wrinkling in each group was evaluated by blinded investigators using a grading scale (Table 2) based on the experimental model proposed by Bissett et al [26].…”

Section: Evaluation Of Photoprotective Effectsmentioning

confidence: 99%

Cosmetic Potential of Enzymatic Treated Ginseng Leaf

Lee¹,

Lee²,

Cho³

et al. 2010

Journal of Ginseng Research

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“…Skin wrinkling in each group was evaluated by blinded investigators using a grading scale (Table 2) based on the experimental model proposed by Bissett et al [26].…”

Section: Evaluation Of Photoprotective Effectsmentioning

confidence: 99%

Cosmetic Potential of Enzymatic Treated Ginseng Leaf

Lee¹,

Lee²,

Cho³

et al. 2010

Journal of Ginseng Research

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“…UV photochemically generated oxidative stressors such as singlet oxygen damage matrix integrity; elastosis-inducing damage to the underlying connective tissue occurs, with interstitial spaces appearing in the matrix caused by loss of collagen volume and fibre binding; the viscosity and quality of the matrix ground substance glycosaminoglycans is reduced; and an inflammatory infiltrate can be identified (1).…”

Section: Viewpointmentioning

confidence: 99%

“…Accumulation of oxidized proteins is a hallmark of cellular ageing and is believed to be one of the main contributors to the aged phenotype (1)(2)(3). This process is dependent on an increased occurrence of oxidative damage to proteins but also on a decreased elimination of oxidatively modified protein (4,5).…”

Section: Viewpointmentioning

confidence: 99%

“…Moreover, the proteasome is playing important intracellular roles not only in degrading misfolded, oxidized and damaged proteins but also in removing native proteins for destruction after they are tagged with ubiquitin. Hence, as pointed out by Norval and McBride in their comment, the UV induced impairment of proteasome function may thus impact important pathways such as the activation of the inflammatoryrelated transcription factor NFKB [1][2][3][4] and the generation of peptides presented on MHC class I receptors which are…”

Section: Viewpointmentioning

confidence: 99%

See 1 more Smart Citation

Viewpoint 3

Trelles¹,

Mordon²,

Calderhead³

2008

Experimental Dermatology

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type I collagen in the dermis (16,36). These observations demonstrate the role of retinoids in both preventing and reversing the signs of UV-induced skin ageing.In conclusion, despite the vast array of 'antiageing' products now available topical retinoids and sunscreens remain the most tried and tested treatments with long established safety records and proven efficacy in the treatment and prevention of UV-induced skin ageing.Stephanie Ogden, Christopher EM Griffiths 13 Sendagorta E, Lesiewicz J, Armstrong R B. J Am Acad Dermatol 1992: 27: S15-S18. Viewpoint 3Excessive skin exposure to solar UV brings about detrimental histological changes in the skin, which combine with and accelerate the effects of chronological ageing, and which result in the lax, dull and wrinkled appearance of 'old' skin. UV photochemically generated oxidative stressors such as singlet oxygen damage matrix integrity; elastosis-inducing damage to the underlying connective tissue occurs, with interstitial spaces appearing in the matrix caused by loss of collagen volume and fibre binding; the viscosity and quality of the matrix ground substance glycosaminoglycans is reduced; and an inflammatory infiltrate can be identified (1).The elegant idea of using light to repair the damage caused by overexposure to light was heralded by the indication of first the CO 2 and the Er:YAG lasers in the early 1990s, (2-4) and then a system which combined both wavelengths in the one console (5,6). Although still regarded as the 'gold standard' in the rejuvenation of seriously photoaged skin, laser ablative resurfacing is simply a controlled second degree burn of the dermis and is associated with, at best, unpleasant side effects and a long downtime.A non-ablative approach using lasers and intense pulsed light (IPL) systems delivered a zone of controlled dermal photothermal damage under an intact epidermis to 'kickstart' the wound healing process recognized as essential in successful skin rejuvenation. The very good histological evidence of tightening of the typically elastotic dermis failed to be echoed in a younger-looking epidermis, and patient satisfaction with single modality non-ablative skin rejuvenation was extremely low (7-10). The combination of single modality systems based on wavelength-specific photobiological precepts produced much better visible results (11-13).Fractional photothermolysis was next proposed for skin rejuvenation (14,15), to bridge the gap between ablative and non-ablative technologies by delivering controlled microdamage to both the epidermis and dermis. Some good results have been reported, but patient satisfaction has again been fickle with fractional technology on its own,

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“…On the other hand, topical sphingolipids are expected to contribute directly to skin function. Our study was conducted to examine the effects of topical application of maize GluCer on wrinkle formation and epidermal thickness in long-term UVA-irradiated hairless mice 10 . Our results indicate that topical GluCer can prevent skin photoaging caused by UVA exposure in mice.…”

Section: Introductionmentioning

confidence: 99%