An anti-inflammatory effect of red microalga polysaccharides in coronary artery endothelial cells

Levy‐Ontman, Oshrat; Huleihel, Mahmoud; Hamias, Rachel; Wolak, Talya; Paran, Esther

doi:10.1016/j.atherosclerosis.2017.07.017

Cited by 51 publications

(23 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These metabolites are commonly found in microalgal biomass and are highly relevant, since they are known to display a wide range of biological activities. For example, it has been reported that microalgal biomass contains molecules with antioxidant, metal-chelating, antidiabetic, antibiotic, antifungal, antiviral, anti-inflammatory, anticancer, and neuroprotective properties [11,12,13,14,15]. Furthermore, n -3 fatty acids and carotenoids are frequently recognized as molecules that could prevent medical conditions, such as cardiovascular and autoimmune diseases [16].…”

Section: Introductionmentioning

confidence: 99%

Nutritional Potential and Toxicological Evaluation of Tetraselmis sp. CTP4 Microalgal Biomass Produced in Industrial Photobioreactors

Pereira

Silva²,

Santos

et al. 2019

Molecules

View full text Add to dashboard Cite

Commercial production of microalgal biomass for food and feed is a recent worldwide trend. Although it is common to publish nutritional data for microalgae grown at the lab-scale, data about industrial strains cultivated in an industrial setting are scarce in the literature. Thus, here we present the nutritional composition and a microbiological and toxicological evaluation of Tetraselmis sp. CTP4 biomass, cultivated in 100-m3 photobioreactors at an industrial production facility (AlgaFarm). This microalga contained high amounts of protein (31.2 g/100 g), dietary fibres (24.6 g/100 g), digestible carbohydrates (18.1 g/100 g) and ashes (15.2 g/100 g), but low lipid content (7.04 g/100 g). The biomass displayed a balanced amount of essential amino acids, n-3 polyunsaturated fatty acids, and starch-like polysaccharides. Significant levels of chlorophyll (3.5 g/100 g), carotenoids (0.61 g/100 g), and vitamins (e.g., 79.2 mg ascorbic acid /100 g) were also found in the biomass. Conversely, pathogenic bacteria, heavy metals, cyanotoxins, mycotoxins, polycyclic aromatic hydrocarbons, and pesticides were absent. The biomass showed moderate antioxidant activity in several in vitro assays. Taken together, as the biomass produced has a balanced biochemical composition of macronutrients and (pro-)vitamins, lacking any toxic contaminants, these results suggest that this strain can be used for nutritional applications.

show abstract

Section: Introductionmentioning

confidence: 99%

Nutritional Potential and Toxicological Evaluation of Tetraselmis sp. CTP4 Microalgal Biomass Produced in Industrial Photobioreactors

Pereira

Silva²,

Santos

et al. 2019

Molecules

View full text Add to dashboard Cite

show abstract

“…24 We demonstrated here that the newly Porphyridium cruentum activates endothelin-1(ET-1) and enhances vascular tonicity. 26 Meanwhile, Porphyridium cruentum, Angelica polymorpha sinensis root extract, and Portulaca oleracea inhibit inflammation [27][28][29][30] leading to reduction in erythema. Moreover, Angelica polymorpha sinensis root can decrease melanin production by inhibiting tyrosinase activity, 31 resulting reduction in L* value (increased skin whiteness).…”

Section: Discussionmentioning

confidence: 99%

An herbal cream reduces erythema of sensitive skin

Zhang

Yuan

Humbert³

et al. 2020

J of Cosmetic Dermatology

View full text Add to dashboard Cite

Sensitive skin manifests as a syndrome defined by the occurrence of unpleasant sensations such as stinging, burning, pain, pruritus, and tingling. 1,2 Clinical signs of sensitive skin include erythema, scaling, and edema. 3 Prevalence of sensitive skin in general population can be as high as over 50%. 4,5 While not life-threatening, signs and symptoms can negatively impact the quality of people's lives. The pathomechanisms of sensitive skin are not clear yet. Recent studies suggest that defective epidermal permeability barrier function could contribute to the development of sensitive skin. 6 A defective permeability barrier can activate transient receptor potential vanilloid-1

show abstract

“…Proinflammatory cytokines, including TNF-α, IL-1, and IL-6, that trigger pro-resorptive actions are highly upregulated by A. actinomycetemcomitans, and thus promote osteoclast formation and bone resorption (Swastini et al 2019). A. actinomycetemcomitans infection leads to increases in the pro-inflammatory cytokines TNF-α, IL-17, and RANKL, and decreases in the anti-inflammatory cytokines IL-10, TGF-β, and OPG (Izawa et al 2014;Araujo-Pires et al 2015;Levy-Ontman et al 2017).…”

Section: Groupmentioning

confidence: 99%

Effectiveness of oral irrigation with an extract of green microalga Nannochloropsis oculata as an anti-inflammatory in rats infected with Aggregatibacter actinomycetemcomitans

et al. 2020

View full text Add to dashboard Cite

Abstract. Revianti S, Andriani D, Parisihni K, Wahjuningsih E, Widyastuti. 2020. Effectiveness of oral irrigation with an extract of green microalga Nannochloropsis oculata as an anti-inflammatory in rats infected with Aggregatibacter actinomycetemcomitans. Biodiversitas 21: 2977-2981. Aggressive periodontitis is strongly correlated with Aggregatibacter actinomycetemcomitans, a periodontopathic bacterium, which releases endotoxins and lipopolysaccharides (LPS). LPS acts as a stimulus to a variety of host cells that can promote the expression of pro-inflammatory cytokines, such as the tumor necrosis factor-α (TNF-α), in periodontal disease. The marine green microalga Nannochloropsis oculata has anti-inflammatory properties. This study aimed to examine the anti-inflammatory efficacy of oral irrigation with N. oculata extract against periodontitis induced by A. actinomycetemcomitans in a rat model. Twenty-four male Wistar rats were divided randomly into four groups (n = 6). First control group was without any treatment, the second to fourth groups were infected with A. actinomycetemcomitans and then orally irrigated with N. oculata extract at concentrations of 2.375%, 2.5%, and 2.625%. The mandibles of the euthanized rats were hemisected to measure the expression of TNF-α, interleukin-10 (IL-10, an anti-inflammatory cytokine), and osteoprotegerin (OPG) by immunohistochemistry. The first group (control) showed significantly higher expression of TNF-α and significantly lower expression of IL-10 and OPG compared to the other groups. Oral irrigation with N. oculata extracts reduced the expression of TNF-α and enhanced the expression of IL-10 and OPG in rats infected with A. actinomycetemcomitans. The effective concentration of N. oculata extract as an anti-inflammatory for oral irrigation was 2.375%.

show abstract

An anti-inflammatory effect of red microalga polysaccharides in coronary artery endothelial cells

Cited by 51 publications

References 39 publications

Nutritional Potential and Toxicological Evaluation of Tetraselmis sp. CTP4 Microalgal Biomass Produced in Industrial Photobioreactors

Nutritional Potential and Toxicological Evaluation of Tetraselmis sp. CTP4 Microalgal Biomass Produced in Industrial Photobioreactors

An herbal cream reduces erythema of sensitive skin

Effectiveness of oral irrigation with an extract of green microalga Nannochloropsis oculata as an anti-inflammatory in rats infected with Aggregatibacter actinomycetemcomitans

Contact Info

Product

Resources

About