An anti-oxidative therapy for ameliorating cardiac injuries of critically ill COVID-19-infected patients

Wang, Jing-Zhang; Zhang, Ruiying; Bai, Jing

doi:10.1016/j.ijcard.2020.04.009

Cited by 77 publications

(75 citation statements)

References 5 publications

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“…Increased plasma concentrations of interleukin (IL), such as IL-1β, IL-2, IL-6, IL-7, IL-8, IL-10, or IL-17, interferon (IFN)γ, IFNγ-inducible protein 10, monocyte chemoattractant protein 1 (MCP1), granulocyte-macrophage colony-stimulating factor (GM-CSF), macrophage inflammatory protein 1α, and tumor necrosis factor-alpha (TNFα), among others, have been found as inflammatory mediators in COVID-19 [ 39 , 40 , 41 , 42 , 43 , 44 ]. Importantly, macrophages and neutrophils also play a potential pathological role during SARS-CoV-2 infection [ 33 ] by producing numerous ROS, including but not limited to H 2 O 2 , O 2 •− and hydroxyl radical ( • OH) [ 45 ]. Oxidative stress affects the immune system throughout altering immune cell function and inflammatory response [ 46 , 47 ].…”

Section: Molecular Pathogenesis Of Covid-19mentioning

confidence: 99%

Oxidative Stress and Inflammation in COVID-19-Associated Sepsis: The Potential Role of Anti-Oxidant Therapy in Avoiding Disease Progression

et al. 2020

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Since the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) outbreak emerged, countless efforts are being made worldwide to understand the molecular mechanisms underlying the coronavirus disease 2019 (COVID-19) in an attempt to identify the specific clinical characteristics of critically ill COVID-19 patients involved in its pathogenesis and provide therapeutic alternatives to minimize COVID-19 severity. Recently, COVID-19 has been closely related to sepsis, which suggests that most deceases in intensive care units (ICU) may be a direct consequence of SARS-CoV-2 infection-induced sepsis. Understanding oxidative stress and the molecular inflammation mechanisms contributing to COVID-19 progression to severe phenotypes such as sepsis is a current clinical need in the effort to improve therapies in SARS-CoV-2 infected patients. This article aims to review the molecular pathogenesis of SARS-CoV-2 and its relationship with oxidative stress and inflammation, which can contribute to sepsis progression. We also provide an overview of potential antioxidant therapies and active clinical trials that might prevent disease progression or reduce its severity.

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Section: Molecular Pathogenesis Of Covid-19mentioning

confidence: 99%

Oxidative Stress and Inflammation in COVID-19-Associated Sepsis: The Potential Role of Anti-Oxidant Therapy in Avoiding Disease Progression

et al. 2020

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“…As the elderly population is more prone to infection, it will be beneficial to investigate vitamin E for potential health benefits against COVID-19. Certainly, a combination of vitamins E and C has been suggested as the beneficial antioxidant therapy for gastric cardia complications of the novel coronavirus [43]. [45] had examined plasma lipid levels in patients with acquired immunodeficiency syndrome (AIDS) and had discovered a particular and explicit absence of the long-chain PUFAs of omega-3 in their diet, which are found in high quantity in fish oils.…”

Section: Role Of Nutritionmentioning

confidence: 99%

A Rapid Advice Guideline for the Prevention of Novel Coronavirus Through Nutritional Intervention

2020

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Purpose of Review An unexpected and sudden outbreak of a novel infection known as a coronavirus (COVID-19) has imposed important problems to global well-being and economy. Based upon current researches, this virus is spreading from one human to another through respiratory droplets, i.e. cough and sneeze. Till now, there has not been any specific treatment found for this virus. Hence, there is a critical need to discover alternative techniques to cope with the current scenario. Recent Findings This review conducted an online search for prevention of coronavirus infection with the help of nutritional interventions. It has been observed that the effect of the virus is mostly on the individual with low immunity, individual affected with diseases like diabetes, and individual using any immune-suppressed drug or having past history of major surgeries or severe medical conditions. Summary Therefore, consuming foods which boost immunity helps in preventing respiratory-related disorder or suppressing diseases-related problems, which could be helpful in controlling the spread of this virus. In conclusion, it has been suggested that before the beginning of generalised treatments and interventions in each infected patient, nutritional status should be evaluated, as it can help in creating a specific nutrition intervention for the infected individual.

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“…During a viral infection, the blood level of vitamin C can drop significantly, to counteract which in the abovementioned study, large doses of vitamin C are administered to patients intravenously: 24 g/day for 7 days ( Carr, 2020 ). Wang et al suggest using vitamins C and E as antioxidant therapy for patients with COVID-19, and imply that molecules such as Curcumin and Baicalin may also be effective ( Wang et al, 2020 ) ( Fig. 3 ).…”

Section: Oxidative Stressmentioning

confidence: 99%

“…Other authors suggest the use of anti-aggregation therapy to combat thrombosis in COVID-19 treatment ( Cattaneo et al, 2020 ). A number of antioxidants were suggested to ameliorate oxidative stress ( Carr, 2020 ; Wang et al, 2020 ). Thus, most of the drugs currently suggested for the treatment of COVID-19 act upon only one of the three listed factors.…”

Section: Introductionmentioning

confidence: 99%

An overview of the pathogenic mechanisms involved in severe cases of COVID-19 infection, and the proposal of salicyl-carnosine as a potential drug for its treatment

Лопачев

Kazanskaya

Khutorova

et al. 2020

European Journal of Pharmacology

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Multiple organ failure in COVID-19 patients is a serious problem which can result in a fatal outcome. Damage to organs and tissues, including general lung dysfunction, develops as a consequence of ischemia, which, in turn, is caused by thrombosis in small blood vessels and hypoxia, leading to oxidative stress and inflammation. Currently, research is underway to screen existing drugs for antioxidant, antiplatelet and anti-inflammatory properties. Having studied the available publications concerning the mechanisms of damage to tissues and organs of patients with COVID-19, as well as the available treatment strategies, we propose to investigate salicyl-carnosine as a potential drug for treating COVID-19 patients. In a recent study, we described the drug’s synthesis procedure, and showed that salicyl-carnosine possesses antioxidant, anti-inflammatory, and antiplatelet effects. Therefore, it can simultaneously act on the three pathogenetic factors involved in tissue and organ damage in COVID-19. Thus, we propose to consider salicyl-carnosine as a potential drug for the treatment of patients with severe cases of COVID-19 infection.

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An anti-oxidative therapy for ameliorating cardiac injuries of critically ill COVID-19-infected patients

Cited by 77 publications

References 5 publications

Oxidative Stress and Inflammation in COVID-19-Associated Sepsis: The Potential Role of Anti-Oxidant Therapy in Avoiding Disease Progression

Oxidative Stress and Inflammation in COVID-19-Associated Sepsis: The Potential Role of Anti-Oxidant Therapy in Avoiding Disease Progression

A Rapid Advice Guideline for the Prevention of Novel Coronavirus Through Nutritional Intervention

An overview of the pathogenic mechanisms involved in severe cases of COVID-19 infection, and the proposal of salicyl-carnosine as a potential drug for its treatment

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