An Antibiotic from Maggots

Pavillard, E. R.; Wright, E. A.

doi:10.1038/180916b0

Cited by 96 publications

(60 citation statements)

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“…The growth of S. epidermidis and P. mirabilis was not inhibited by ES <500 or nES using the TB assay, however, there is evidence of an important biological effect on S. epidermidis biofilms by nES (Harris and Mack, unpublished). Proteus has been shown in previous studies to be resistant to the effects of unfractionated maggot ES [13,20] and, in the present study, incubation of P. mirabilis and S. epidermidis with multiple doses of nES or with a reduced bacterial inoculum failed to inhibit growth.…”

Section: Discussionsupporting

confidence: 61%

The antibacterial activity against MRSA strains and other bacteria of a <500 Da fraction from maggot excretions/secretions of Lucilia sericata (Diptera: Calliphoridae)

Bexfield

Bond

Roberts

et al. 2008

Microbes and Infection

120

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Section: Discussionsupporting

confidence: 61%

The antibacterial activity against MRSA strains and other bacteria of a <500 Da fraction from maggot excretions/secretions of Lucilia sericata (Diptera: Calliphoridae)

Bexfield

Bond

Roberts

et al. 2008

Microbes and Infection

120

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“…[23] . Pavillard and Wright [24] reported that maggot secretion had an antibacterial effect against Pneumococci, Streptococci group A and B and S. aureus, but had no effect on C. albicans, B. subtilis, E. coli, S. typhimurium and P. vulgaris . In the study conducted by Thomas et al [23] , maggot secretions harvested by rinsing the maggots had an inhibitory effect on S. aureus and Streptococci group A and B, a moderate effect on MRSA and P. aeruginosa, and no effect on E. coli, P. mirabilis and Enterococcus spp.…”

Section: Discussionmentioning

confidence: 99%

In vitro Antibacterial Activity of <i>Lucilia sericata</i> Maggot Secretions

Daeschlein

Mumcuoglu

Assadian³

et al. 2006

Skin Pharmacol Physiol

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Maggots of the green blowfly, Lucilia sericata, are used as an alternative to surgical intervention and long-term antiseptic therapy for the treatment of chronic wounds. The secretions of maggots are known to have antibacterial properties. To quantify the bactericidal effect of secretions from larvae of L. sericata, an in vitro test model based on the modified European quantitative suspension test (EN 1040) was developed, in which a co-culture of maggots and bacteria (Micrococcus luteus,Escherichia coli, methicillin-sensitive Staphylo-coccus aureus) in tryptic soy broth was tested. The numbers of bacterial colonies with and without maggot exposure were compared after 24, 48 and 72 h of exposure. The mean log₁₀ reduction factor (RF) for bacterial elimination per maggot was >4 at all examined times for all tested bacteria. Thus, maggot secretion fulfilled the required definitions of an antiseptic. In addition, the maggots’ ability to ingest bacteria was also evaluated. Maggots contained viable bacteria after 48 h of contact with the respective organisms. These maggots also continued excreting bacteria. Therefore, maggots should be disposed of after use as they must be regarded as medical waste.

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“…According to the protocol recommended by the American diabetes association (ADA), one of the preventive tactics in diabetes care is multidisciplinary team approach where its advantages are shown in several studies (7,8). The members of the team for diabetic foot care usually consists of general practitioner, nurse, educator, and … Although all team members have an influence on reducing the incidence of a foot ulcer and amputation, however, the role of a nurse is essential (9).…”

Section: Introductionmentioning

confidence: 99%

Maggot Debridement Therapy for Diabetic Foot Ulcer: A Case Report

Hajimohammad¹,

Esmaili²,

Rahimi³

2017

Crit Care Nurs J

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Introduction: Diabetic foot problems account for more hospital admissions than any other long term complications of diabetes and are responsible for nearly 50% of all-diabetes-related hospital bed days. Maggot debridement therapy (MDT) offers important advantages for the management of chronic and infected wounds and is used in hundreds of clinics worldwide. This study aimed to evaluate the benefit of maggot debridement therapy (MDT) in the treatment of a patient with a diabetic foot ulcer (DFU). Case Presentation: A 46-year-old male patient with a 6-year-old diabetic foot wound in the right leg. Maggot larvae were placed on the wound. The patient was followed for 6 weeks and luckily had a good response to treatment. Conclusions: This study concluded that MDT is as powerful as traditional debridement in the treatment of diabetic foot ulcers. It would be an achievable different option for diabetic foot ulcer treatment. In conclusion, we observed that MDT could promote wound healing by increasing endothelial proliferation, triggering angiogenesis, and maggot excretion/secretion, which might facilitate this process.

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An Antibiotic from Maggots

Cited by 96 publications

References 0 publications

The antibacterial activity against MRSA strains and other bacteria of a <500 Da fraction from maggot excretions/secretions of Lucilia sericata (Diptera: Calliphoridae)

The antibacterial activity against MRSA strains and other bacteria of a <500 Da fraction from maggot excretions/secretions of Lucilia sericata (Diptera: Calliphoridae)

In vitro Antibacterial Activity of <i>Lucilia sericata</i> Maggot Secretions

Maggot Debridement Therapy for Diabetic Foot Ulcer: A Case Report

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