An antifouling and antibacterial electrochemical biosensor for detecting aminopeptidase N cancer biomarker in human urine

Li, Yang; Han, Rui; Yu, Xiaohang; Chen, Min; Chao, Qiqi; Liu, Xiang

doi:10.1016/j.snb.2022.132723

Cited by 13 publications

(6 citation statements)

References 40 publications

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“…39 BSA blocks unbound active sites to form an antifouling interface. 40,41 The fabricated LIG/PEDOT/Au/GOx micro sensing electrode, in combination with smartphone device, enables data visualization and improves the applicability for self and home-based healthcare management of diabetic patients. This is essential for prolonging the time of clinical diagnosis, both indoors and outdoors.…”

Section: Glucose Sensing Strategy Using Enzyme Electrodesmentioning

confidence: 99%

Portable glucose sensing analysis based on laser-induced graphene composite electrode

Zhang,

Huang,

Chen

et al. 2024

RSC Adv.

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Section: Glucose Sensing Strategy Using Enzyme Electrodesmentioning

confidence: 99%

Portable glucose sensing analysis based on laser-induced graphene composite electrode

Zhang,

Huang,

Chen

et al. 2024

RSC Adv.

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“…Distinguishing the targeted cancer biomarkers from this complex milieu is extremely difficult. Non-specific adsorption and matrix effects often produce false signals leading to inaccurate results[ 35 ]. Novel surface chemistries, nanostructured coatings and creative receptor scaffolds are being explored to impart sensor selectivity[ 36 ].…”

Section: Challenges and Limitations Must Be Addressedmentioning

confidence: 99%

Leveraging electrochemical sensors to improve efficiency of cancer detection

Fu,

Karimi-Maleh

2024

World J Clin Oncol

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Electrochemical biosensors have emerged as a promising technology for cancer detection due to their high sensitivity, rapid response, low cost, and capability for non-invasive detection. Recent advances in nanomaterials like nanoparticles, graphene, and nanowires have enhanced sensor performance to allow for cancer biomarker detection, like circulating tumor cells, nucleic acids, proteins and metabolites, at ultra-low concentrations. However, several challenges need to be addressed before electrochemical biosensors can be clinically implemented. These include improving sensor selectivity in complex biological media, device miniaturization for implantable applications, integration with data analytics, handling biomarker variability, and navigating regulatory approval. This editorial critically examines the prospects of electrochemical biosensors for efficient, low-cost and minimally invasive cancer screening. We discuss recent developments in nanotechnology, microfabrication, electronics integration, multiplexing, and machine learning that can help realize the potential of these sensors. However, significant interdisciplinary efforts among researchers, clinicians, regulators and the healthcare industry are still needed to tackle limitations in selectivity, size constraints, data interpretation, biomarker validation, toxicity and commercial translation. With committed resources and pragmatic strategies, electrochemical biosensors could enable routine early cancer detection and dramatically reduce the global cancer burden.

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“…Herein, we constructed an antifouling ratiometric ECL sensor to detect OTC in water. The antifouling part mainly utilizes the electroneutrality and hydrophilicity of the zwitterionic SBMA, , and the strong hydration layer formed by it can reduce the interference of nonspecific adsorption. − As shown in Scheme , SBMA and SiO 2 are covalently bonded to form antifouling nanospheres (NPs), which can be loaded onto the MXene and improve its stability in the ocean. The introduction of carrier MXene is beneficial to improve the conductivity and specific surface area and can also increase the load of antifouling NPs and enhance the antifouling performance. , On this basis, the introduction of Au@luminol as an internal standard molecule , can improve the conductivity and can also use the Au–S bond to provide more aptamer connection sites to improve sensitivity.…”

Section: Introductionmentioning

confidence: 99%

Ultrasensitive Ratiometric Electrochemiluminescence Sensor with an Efficient Antifouling and Antibacterial Interface of PSBMA@SiO₂-MXene for Oxytetracycline Trace Detection in the Marine Environment

Ding,

Zhang,

Wang

et al. 2023

Anal. Chem.

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The sensitivity and accuracy of electrochemiluminescence (ECL) sensors for detecting small-molecule pollutants in environmental water are affected not only by nonspecific adsorption of proteins and other molecules but also by bacterial interference. Therefore, there is an urgent need to develop an ECL sensor with antifouling and antibacterial functions for water environment monitoring. Herein, a highly efficient antifouling sensing interface (PSBMA@SiO 2 -MXene) based on zwitterionic sulfobetaine methacrylate (SBMA) antifouling nanospheres (NPs) and two-dimensional MXene nanosheets was designed for the sensitive detection of oxytetracycline (OTC), an antibiotic small-molecule pollutant. Specifically, SBMA with good hydrophilicity and electrical neutrality was connected to SiO 2 NPs, thus effectively reducing protein and bacterial adsorption and improving stability. Second, MXene with a high specific surface area was selected as the carrier to load more antifouling NPs, which greatly improves the antifouling performance. Meanwhile, the introduction of MXene also enhances the conductivity of the antifouling interface. In addition, a ratio-based sensing strategy was designed to further improve the detection accuracy and sensitivity of the sensor by utilizing Au@luminol as an internal standard factor. Based on antifouling and antibacterial interfaces, as well as internal standard and ratiometric sensing strategies, the detection range of the proposed sensor was 0.1 ng/mL to 100 μg/mL, with a detection limit of 0.023 ng/mL, achieving trace dynamic monitoring of antibiotics in complex aqueous media.

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An antifouling and antibacterial electrochemical biosensor for detecting aminopeptidase N cancer biomarker in human urine

Cited by 13 publications

References 40 publications

Portable glucose sensing analysis based on laser-induced graphene composite electrode

Portable glucose sensing analysis based on laser-induced graphene composite electrode

Leveraging electrochemical sensors to improve efficiency of cancer detection

Ultrasensitive Ratiometric Electrochemiluminescence Sensor with an Efficient Antifouling and Antibacterial Interface of PSBMA@SiO₂-MXene for Oxytetracycline Trace Detection in the Marine Environment

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An antifouling and antibacterial electrochemical biosensor for detecting aminopeptidase N cancer biomarker in human urine

Cited by 13 publications

References 40 publications

Portable glucose sensing analysis based on laser-induced graphene composite electrode

Portable glucose sensing analysis based on laser-induced graphene composite electrode

Leveraging electrochemical sensors to improve efficiency of cancer detection

Ultrasensitive Ratiometric Electrochemiluminescence Sensor with an Efficient Antifouling and Antibacterial Interface of PSBMA@SiO2-MXene for Oxytetracycline Trace Detection in the Marine Environment

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Product

Resources

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Ultrasensitive Ratiometric Electrochemiluminescence Sensor with an Efficient Antifouling and Antibacterial Interface of PSBMA@SiO₂-MXene for Oxytetracycline Trace Detection in the Marine Environment