An antifungal norditerpene dilactone from Podocarpus nagi

Kubo, Isao; Himejima, Masaki; Ying, Bai-Ping

doi:10.1016/0031-9422(91)84188-x

Cited by 22 publications

(25 citation statements)

References 19 publications

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“…The bioactive compounds 2 β -hydroxynagilactone F ( 39 ) and nagilactone I ( 40 ) were originally isolated from the root bark of the Japanese evergreen Podocarpus nagi . 104, 105 The proposed structures 39a and 40a included an α -hydroxy at C-2, which was established from the half-height width of the H-2 NMR signal and the assumption that ring A adopted a chair conformation (Fig. 8A).…”

Section: Structural Revision Based On Nmr Spectroscopic Analysis Anmentioning

confidence: 99%

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Recent trends in the structural revision of natural products

et al. 2018

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Covering: 2012 to 2017 This article reviews recent reports on the structural revision of natural products. Through a critical assessment of the original and revised published structures, the article addresses why each structure was targeted for revision, discusses the techniques and key discrepancies that led to the proposal of the revised structure, and offers measures that may have been taken during the original structure determination to prevent error. With the revised structures in hand, weaknesses of original proposals are assessed, providing a better understanding on the logic behind structure determination.

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Section: Structural Revision Based On Nmr Spectroscopic Analysis Anmentioning

confidence: 99%

“…The absence of a NOESY correlation expected for structure 39a due to a 1,3-diaxial interaction between H-2 and the methyl group at C-10 should have raised red a flag on the validity of the original structure. 105…”

Section: Structural Revision Based On Nmr Spectroscopic Analysis Anmentioning

confidence: 99%

Recent trends in the structural revision of natural products

et al. 2018

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“…Nagilactone C, nagilactone D, nagilactone E also exhibited inhibitory effects on fungi. Tartalol exhibited stronger inhibitory activity against staphylococcus aureus, while tartalol and totaradiol exhibited peculiar inhibitory activity against Gram-positive bacteria, and norditerpenoid dilactone showed peculiar activity against saccharomyces cerevisiae, blastomyces albicans and pityrosporum (Malassezia) ovale [13][14][15][16][17][18].…”

Section: Anti-bacterial Activitymentioning

confidence: 99%

Chemical and biological progress of Podocarpus nagi

Yang¹,

Yong²,

Lu³

2018

Biomed Res Rev

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Podocarpus nagi is a tree belonging to the family of Podocarpaceae, which has ever been used for treatment of trauma, stop-bleeding, fractures, knife wounds, gunshot wounds, body odor, eye diseases, colds and rheumatoid arthritis in clinic. Some compounds have been isolated and their biological activities were also evaluated. This review briefly describes the progress of the chemical components and biological activities of podocarpus nagi, for providing a reference for the researchers.

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“…Several norditerpene dilactone have been isolated from the root bark of Podocarpus nagi [62][63][64]. These include 2,3dihydro- 16 Not only the root bark, also the stem bark of podocarpus nagi has been reported [65] to yield a bisnorditerpene dilactone nagilactone J (49) Fig.…”

Section: Norditerpene Dilactonesmentioning

confidence: 99%

The Chemistry of Bioactive Diterpenes

Banerjee¹,

Laya²,

Mora³

et al. 2008

COC

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This article reviews the isolation, biological activity and syntheses of several diterpenes. The chemistry and biological activities of norditerpene dilactones have been described. The aim of the present article is to provide an overview on the important role of diterpenoid compounds in medicine and agriculture. The synthetic discussions of these diterpenes are very briefly described. Dedicated to Professor Kenji Mori for his valuable contributions to Terpene Chemistry.COOH Me Me OH Me Me H The Chemistry of Bioactive Diterpenes

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An antifungal norditerpene dilactone from Podocarpus nagi

Cited by 22 publications

References 19 publications

Recent trends in the structural revision of natural products

Recent trends in the structural revision of natural products

Chemical and biological progress of Podocarpus nagi

The Chemistry of Bioactive Diterpenes

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