An Antiinflammatory and Reactive Oxygen Species Suppressive Effects of an Extract of Polygonum Cuspidatum Containing Resveratrol

Abstract

The PCE-containing resveratrol has a comprehensive suppressive effect on oxidative and inflammatory stress.

Can resveratrol help to maintain metabolic health?

“…Crandall et al (49) examined in a small pilot study the effect of 4 weeks resveratrol treatment, with high doses of 1-2 g/ d on glucose homoeostasis in subjects with an impaired glucose tolerance, and reported that resveratrol was able to reduce postprandial glucose levels. These effects could not be confirmed by Ghanim et al (50) , who reported no beneficial effects of a 6-week intervention with an extract containing 40 mg resveratrol on HOMA-index, performed in healthy volunteers.…”

Resveratrol and health – A comprehensive review of human clinical trials

“…None of the reported changes were observed after the first 2 wk of resveratrol supplementation. It is also noteworthy that Ghanim et al [51] found that fasting glucose, insulin, or HOMA-IR scores remained unchanged following 6 wk of 40 mg resveratrol supplementation (in P. cuspidatum extract) in healthy individuals. Given that symptoms of hypoglycemia have not been reported in any of the bioavailability and safety studies, it appears that resveratrol is likely to be free from one of the major risks associated with many antidiabetic agents, making it an attractive choice if efficacy can be more thoroughly demonstrated.…”

“…This has been observed following red wine consumption [37,49,50], but has not yet been directly measured following resveratrol supplementation in humans. Ghanim et al [51] found that 6 wk of supplementation with 200 mg of P. cuspidatum extract containing 40 mg of resveratrol did not alter fasting plasma concentrations of cholesterol (total, LDL, and HDL), triglycerides, or leptin compared with placebo in 20 healthy individuals. However, mononuclear cells from the resveratrol group demonstrated suppressed nuclear factor kappa B (NFkB) binding, decreased ROS generation, and decreased tumor necrosis factor alpha (TNFa) and IL-6.…”

“…As a whole, the current literature suggests that resveratrol is safe and may promote beneficial changes in health, although further research is necessary. This review identified six peerreviewed publications [31,51,52,57,66,85], one research announcement [58] and one major professional presentation [59] (that has not yet been published in a peer-reviewed form) that measured end points beyond bioavailability and safety, with the longest study being 6 wk in duration. While findings of improved insulin resistance, blood flow, and decreased oxidative stress and inflammation combined with excellent short-term safety point to a promising future, there is no way of knowing if these will translate into long-term health benefits until well-controlled studies are performed.…”

“…For instance, 270 mg transresveratrol [66] and 600 mg of grapeskin extract containingo50 mg trans-resveratrol [87] have been found to comparably increase FMD of the brachial artery one hour following consumption, whereas 90 mg trans-resveratrol [66] tends to have a smaller effect. Ghanim's two studies illustrate this point in that six weeks of P. cuspidatum supplementation did not significantly alter either TLR4 mRNA or protein expression [51], whereas one meal with a resveratrol and grapeskin polyphenol supplement significantly increased TLR4 protein expression [52]. The differing dosages of resveratrol, synergistic compounds, and timing and duration of supplementation could have all influenced the results, but the relative contributions of these factors are unknown.…”