An antimicrobial peptide-immobilized nanofiber mat with superior performances than the commercial silver-containing dressing

Yang, Qiannan; Cui, Sisi; Song, Xin; Hu, Junli; Zhou, Yifa; Liu, Yichun

doi:10.1016/j.msec.2020.111608

Cited by 18 publications

(8 citation statements)

References 49 publications

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“…However, the main antibacterial protocols used in clinical and frontier scientific research, such as antibiotic therapy, photothermal therapy, and heavy metal ion therapy, have certain limitations. For example, overuse of antibiotics will lead to the emergence of “superbugs”; continuous exposure to high photothermal temperatures (above 55 °C) will cause tissue burns; , and the antibacterial concentration of most heavy metal ions is much higher than the biosafety concentration and is not easy to be metabolized by the human body. ,,, Therefore, it has become urgent to design a new antibacterial scheme, which can effectively kill bacteria while giving consideration to both biological safety and activity. Based on the abovementioned requirements, this study designed and prepared the Alg-PDA-Se composite hydrogel, which can effectively kill bacteria and quickly repair damaged wounds within 9 days in a mild thermal environment of 45 °C.…”

Section: Discussionmentioning

confidence: 99%

Mild Heat-Assisted Polydopamine/Alginate Hydrogel Containing Low-Dose Nanoselenium for Facilitating Infected Wound Healing

Younis

Zhang

et al. 2023

ACS Appl. Mater. Interfaces

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In clinical practice, it has become urgent to develop multifunctional wound dressings that can combat infection and prompt wound healing simultaneously. In this study, we proposed a polydopamine/alginate/nanoselenium composite hydrogel (Alg-PDA-Se) for the treatment of infected wounds. In particular, polydopamine endows the composite hydrogel with controllable near-infrared photothermal properties, while low-dosage selenium nanoparticles (Se NPs) offer excellent anti-oxidation, anti-inflammatory, pro-proliferative, pro-migration, and pro-angiogenic performances, which are verified by multiple cells, including macrophages, fibroblasts, and endothelial cells. More interestingly, the combination of mild temperature with low-dosage Se NPs produces a synergistic effect on combating both Staphylococcus aureus (S. aureus) and Escherichia coli (E. coli) and promoting the healing of bacteria-infected wounds in vivo. We anticipate that the designed composite hydrogel might be a potential candidate for anti-infection bioactive dressing.

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Section: Discussionmentioning

confidence: 99%

Mild Heat-Assisted Polydopamine/Alginate Hydrogel Containing Low-Dose Nanoselenium for Facilitating Infected Wound Healing

Younis

Zhang

et al. 2023

ACS Appl. Mater. Interfaces

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“…Antimicrobial assay displayed a more than one-log reduction in E. coli for the membrane. An inhibitory zone against S. aureus was also observed, but not as significant as towards E. coli [ 126 ]. Cyclodextrin was frequently adopted to form inclusion complexes with anti-microbial bioactive compounds such as curcumin [ 127 ], citral [ 128 ], thymol [ 129 ], and more to assist wound healing.…”

Section: Diverse Applications Of Electrospun Food Polysaccharidesmentioning

confidence: 99%

Electrospun Food Polysaccharides Loaded with Bioactive Compounds: Fabrication, Release, and Applications

Lin

Chen

et al. 2023

Polymers

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Food polysaccharides are well acclaimed in the field of delivery systems due to their natural safety, biocompatibility with the human body, and capability of incorporating/releasing various bioactive compounds. Electrospinning, a straightforward atomization technique that has been attracting researchers worldwide, is also versatile for coupling food polysaccharides and bioactive compounds. In this review, several popular food polysaccharides including starch, cyclodextrin, chitosan, alginate, and hyaluronic acid are selected to discuss their basic characteristics, electrospinning conditions, bioactive compound release characteristics, and more. Data revealed that the selected polysaccharides are capable of releasing bioactive compounds from as rapidly as 5 s to as prolonged as 15 days. In addition, a series of frequently studied physical/chemical/biomedical applications utilizing electrospun food polysaccharides with bioactive compounds are also selected and discussed. These promising applications include but are not limited to active packaging with 4-log reduction against E. coli, L. innocua, and S. aureus; removal of 95% of particulate matter (PM) 2.5 and volatile organic compounds (VOCs); heavy metal ion removal; increasing enzyme heat/pH stability; wound healing acceleration and enhanced blood coagulation, etc. The broad potentials of electrospun food polysaccharides loaded with bioactive compounds are demonstrated in this review.

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“…For instance, Yang et al proposed to replace silver by starch nanofiber mats with ε‐PLL to prevent the potential risks of metals in vivo. [ 44 ] ε‐PLL was attached to the starch nanofibers via a cross‐linking method, and the properties of this material were compared to a commercial silver‐containing dressing. The ε‐PLL‐containing nanofibers exhibited antibacterial properties against gram‐positive and gram‐negative bacteria over 14 days, which were accounted for by the release of ε‐PLL during starch degradation.…”

Section: Encapsulation Of ε‐Pllmentioning

confidence: 99%

The High Potential of ε‐Poly‐l‐Lysine for the Development of Antimicrobial Biomaterials

Lebaudy,

Guilbaud-Chéreau,

Frisch

et al. 2023

Advanced NanoBiomed Research

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ε‐poly‐l‐lysine (ε‐PLL) is a natural polypeptide/polycation originating from bacteria. Thanks to its antifungal and antibacterial properties, it is the subject of extensive research in the food and medical industries. ε‐PLL is also used to develop biomaterials in a broad range of applications, such as drug delivery, wound healing, or antimicrobial coatings. Indeed, loading ε‐PLL inside nanoparticles, functionalizing implant surfaces with ε‐PLL, or developing hydrogels based on reactions between ε‐PLL and other polymers can improve the materials properties, leading to biocompatible, antibacterial, and antifungal systems. These characteristics are necessary not only for the development of biomaterials, for their integrity in a biological environment, but also for improving the performances of medical devices. Moreover, ε‐PLL can be used as an alternative to antibiotics as its mechanism of action reduces the bacterial resistance risk compared with antibiotics. Finally, “smart” systems using ε‐PLL may be developed, with controllable material degradation or drug delivery via pH or temperature variations. This review sought to gather the latest research on the development of antimicrobial biomaterials based on the ε‐PLL polypeptide.

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An antimicrobial peptide-immobilized nanofiber mat with superior performances than the commercial silver-containing dressing

Cited by 18 publications

References 49 publications

Mild Heat-Assisted Polydopamine/Alginate Hydrogel Containing Low-Dose Nanoselenium for Facilitating Infected Wound Healing

Mild Heat-Assisted Polydopamine/Alginate Hydrogel Containing Low-Dose Nanoselenium for Facilitating Infected Wound Healing

Electrospun Food Polysaccharides Loaded with Bioactive Compounds: Fabrication, Release, and Applications

The High Potential of ε‐Poly‐l‐Lysine for the Development of Antimicrobial Biomaterials

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