An antioxidant activity of the whole body of Holothuria scabra

Nobsathian, Saksit; Tuchinda, Patoomratana; Sobhon, Prasert; Tinikul, Yotsawan; Poljaroen, Jaruwan; Tinikul, Ruchanok; Sroyraya, Morakot; Poomton, Tanes; Chaichotranunt, Supakant

doi:10.1186/s40538-017-0087-7

Cited by 24 publications

(30 citation statements)

References 10 publications

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“…The ethanol phase was evaporated under vacuum, then the powder was kept at −20°C until use. The compounds in HS were characterized by using nuclear magnetic resonance spectroscopy as previously described ( Nobsathian et al, 2017 ).…”

Section: Methodsmentioning

confidence: 99%

“…HS is rich in triterpene glycosides, such as scabraside A, scabraside B, scabraside D, holothurin A3, holothurin A4, fuscocineroside and 24-dehydroechinoside A, phenols, and flavonoids ( Honey-Escandón et al, 2015 ; Pangestuti and Arifin, 2017 ; Khotimchenko, 2018 ). In addition, phenolic compounds including friedelin, 3-hydroxybenzaldehyde, and 4-hydroxybenzaldehyde isolated from the whole body of HS showed a high antioxidant activity ( Nobsathian et al, 2017 ). In this context, 4-hydroxybenzaldehyde displayed a significant inhibition of superoxide anion generation and elastase release by human neutrophils ( Kuo et al, 2017 ).…”

Section: Introductionmentioning

confidence: 99%

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Neuroprotective and Neurorestorative Effects of Holothuria scabra Extract in the MPTP/MPP+-Induced Mouse and Cellular Models of Parkinson’s Disease

et al. 2020

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Extracts from Holothuria scabra (HS) have been shown to possess anti-inflammation, anti-oxidant and anti-cancer activities. More recently, it was shown to have neuroprotective potential in Caenorhabditis elegans PD model. Here, we assessed whether HS has neuroprotective and neurorestorative effects on dopaminergic neurons in both mouse and cellular models of PD. We found that both pre-treatment and post-treatment with HS improved motor deficits in PD mouse model induced with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) as determined by grid walk test. This was likely mediated by HS protective and restorative effects on maintaining the numbers of dopaminergic neurons and fibers in both substantia nigra pars compacta (SNpc) and striatum. In a cellular model of PD, HS significantly attenuated 1-methyl-4-phenylpyridinium (MPP+)-induced apoptosis of DAergic-like neurons differentiated from SH-SY5Y cells by enhancing the expression of Bcl-2, suppressing the expression of cleaved Caspase 3 and preventing depolarization of mitochondrial membrane. In addition, HS could stimulate the expression of tyrosine hydroxylase (TH) and suppressed the formation of α-synuclein protein. Taken together, our in vivo and in vitro findings suggested that HS is an attractive candidate for the neuroprotection rather than neurorestoration in PD.

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Neuroprotective and Neurorestorative Effects of Holothuria scabra Extract in the MPTP/MPP+-Induced Mouse and Cellular Models of Parkinson’s Disease

et al. 2020

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“…Total polyphenol contents had a weak correlation with the anti-oxidant activity, even in the best case, i.e., DPPH (R 2 = 0.29). It should be noted that there are other anti-oxidant substances in tunicates [11] and sea cucumbers [12] which may be responsible for the effect reported. Comparisons with the relevant literature must consider used methodologies, measurement units, and type of extract.…”

Section: Anti-oxidant Activity and Polyphenol Contentmentioning

confidence: 99%

Biopotential of Sea Cucumbers (Echinodermata) and Tunicates (Chordata) from the Western Coast of Portugal for the Prevention and Treatment of Chronic Illnesses

Carletti

Cardoso

Juliao

et al. 2020

First International Electronic Conference on Nutrients, Microbiota and Chronic Disease

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In the present work, we aimed to explore the potential of two groups of marine invertebrates—sea cucumbers (Echinodermata) and ascidians (Chordata)—as sources of anti-inflammatory, anti-oxidant, and osteogenic compounds with potential to be used as pharmaceuticals and nutraceuticals for the treatment and prevention of chronic diseases. 24 extracts (ethanol, water, and ethyl acetate) from 4 species of sea cucumbers and 4 species of tunicates were produced and screened in vitro for their anti-inflammatory and anti-oxidant activities and in vivo for osteogenic activity through an assay using zebrafish larvae. Our results showed that ethanolic extracts presented anti-oxidant and anti-inflammatory activity, which revealed to be stronger in the ascidians. The osteogenic activity, which provides evidence of the bioactive potential of these organisms in preventing chronic disorders causing low bone density, was found to be strong in one species of ascidians and 3 of holothurians. This study demonstrates the high potential of extracts from these marine organisms for using as nutraceuticals in the prevention of chronic bone disorders.

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“…Namun, aktivitas tinggi radikal bebas dapat menyebabkan berbagai gangguan sel dan jaringan yang pada akhirnya dapat menyebabkan kematian sel, kelainan gen dan kanker (Kulbacka et al, 2012). Senyawa yang berfungsi sebagai antioksidan yang terkandung dalam teripang diantaranya fenol, Vitamin C, vitamin E, dan terpen (Sroyraya et al, 2017;Nobsathian et al, 2017).…”

Section: Pendahuluanunclassified

UJI ANTIOKSIDAN DAN UJI BSLT PADA EKSTRAK KASAR Holothuria scabra DENGAN BERBAGAI PELARUT

Ardiansyah

Rasyid

Nugroho

2019

J. Ilmu dan Teknologi Kelautan Tropis

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Holothuria scabra is one of high-value sea cucumber. The beneficial aspect of sea cucumbers is determined by the source of raw materials. The extraction process is a process that happens before sea cucumbers are used. In this process, the use of a various solvent is not only to facilitate the production process but also to maintain the active material. Also, the amount of yield obtained in the extraction process becomes a consideration in the production process. One of the benefits that are often claimed is antioxidants. This study aims to determine the yield of sea cucumbers after the extraction process by maceration with various types of solvents then antioxidant testing was carried out with DPPH followed by BSLT test. It was commonly used and easy to do. Besides, BSLT test was carried out to determine the initial toxicity and potency to be developed as antibacterial, antifungal and anticancer candidates. Results showed that the highest yield was 8.98% produced by dry sea cucumber samples extracted with ethanol PA 70% ethanol (code T5). In the results of the antioxidant tests, the best IC50 comes from dried sea cucumber extracted using ethyl acetate (code T2 and T3) with 1140 ± 0.00 ppm and1140 ± 10 ppm respectively. In the BSLT test results, the lowest LC50 was shown by extract using 100% methanol PA solvent (T4 code), with 108 ppm.

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An antioxidant activity of the whole body of Holothuria scabra

Cited by 24 publications

References 10 publications

Neuroprotective and Neurorestorative Effects of Holothuria scabra Extract in the MPTP/MPP+-Induced Mouse and Cellular Models of Parkinson’s Disease

Neuroprotective and Neurorestorative Effects of Holothuria scabra Extract in the MPTP/MPP+-Induced Mouse and Cellular Models of Parkinson’s Disease

Biopotential of Sea Cucumbers (Echinodermata) and Tunicates (Chordata) from the Western Coast of Portugal for the Prevention and Treatment of Chronic Illnesses

UJI ANTIOKSIDAN DAN UJI BSLT PADA EKSTRAK KASAR Holothuria scabra DENGAN BERBAGAI PELARUT

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