An antioxidant, N,N′-diphenyl-p-phenylenediamine (DPPD), affects labor and delivery in rats: A 28-day repeated dose test and reproduction/developmental toxicity test

Matsumoto, Mariko; Yamaguchi, Makiko; Yoshida, Yuka; Senuma, Mika; Takashima, Hiromasa; Kawamura, Tomoko; Kato, Hina; Takahashi, Mika; Hirata-Koizumi, Mutsuko; Ono, Atsushi; Yokoyama, Kazuhito; Hirose, Akihiko

doi:10.1016/j.fct.2013.02.029

Cited by 43 publications

(29 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This may be owing to the phenylenediamine. Phenylenediamine derivatives have well reported antioxidant activity, 39 which is primarily due to three mechanisms: (i) free-radical scavenging ability, 40 (ii) inhibition of oxidative glutamate toxicity and (iii) acting as peroxide decomposers by eliminating oxidative catalyst to avoid further oxidation. 41 3.4.3 Estimation of total protein content.…”

Section: Surface Charge Measurementmentioning

confidence: 99%

In vitro cytocompatibility and blood compatibility of polysulfone blend, surface-modified polysulfone and polyacrylonitrile membranes for hemodialysis

et al. 2015

View full text Add to dashboard Cite

show abstract

Section: Surface Charge Measurementmentioning

confidence: 99%

In vitro cytocompatibility and blood compatibility of polysulfone blend, surface-modified polysulfone and polyacrylonitrile membranes for hemodialysis

et al. 2015

View full text Add to dashboard Cite

show abstract

“…10 A 28 day repeated dose toxicity test showed that DPPD affected labor and delivery in rats. 11 A newly identified ozonation transformation product of 6PPD, named 6PPDqunione (6PPD-Q), was reported to be responsible for the mysterious acute mortality of salmon in urban creeks from the Pacific northwest of the United States. 4 These available studies revealed the environmental occurrences of PPDs and potential toxic and ecotoxic effects, but knowledge of their sources, environmental behavior, and fate remains largely insufficient.…”

Section: ■ Introductionmentioning

confidence: 99%

Occurrence of Substituted p-Phenylenediamine Antioxidants in Dusts

Huang

Shi

Huang

et al. 2021

Environ. Sci. Technol. Lett.

146

View full text Add to dashboard Cite

The substituted p-phenylenediamines (PPDs) represent a suite of effective antioxidants broadly applied in rubber industries. However, knowledge of their environmental occurrences and fate remains extremely limited. Herein, we explored the occurrence of six major PPD antioxidants and one newly defined transformation product in dust particles from different environments, including roads, underground parking lots, vehicles, and houses. The majority of the PPDs exhibited ubiquitous occurrence in these environments. Median concentrations of total PPDs were determined to be 226 ng/g in road dust, 232 ng/g in parking lot dust, and 156 ng/g in vehicle dust, orders of magnitude greater than those in house dust (14.0 ng/g). Different composition profiles of PPDs were also found between house dust and vehicle-related dust, likely indicating the influence of vehicle tires or other rubber products. In addition, a major ozonation product of N-(1,3-dimethylbutyl)-N′-phenyl-1,4-phenylenediamine (6PPD), 6PPD-qunione, was also identified in dust with levels (median range of 32.2–80.9 ng/g) comparable to that of 6PPD except in house dust. To the best of our knowledge, this is the first systematic investigation of the occurrence of major PPD antioxidants and 6PPD-qunione in various dust matrices. Our findings would attract attention to their environmental fate and ecological and human health risks.

show abstract

“…HgCl 2 demolishes free radical scavenging systems such as superoxide dismutase and catalase [6], as well as increase reactive species levels that lead to disturbance of the prooxidant-antioxidant balance system causing a condition of oxidative stress [7]. N N′-diphenyl-1, 4-phenylenediamine, a grey or dark grey powder, is used as an antioxidant in rubber and oils, especially for tires in industry due to its colour and stability [8]. DPPD is one of the most frequently used and potent antioxidants.…”

Section: Introductionmentioning

confidence: 99%

“…N N′-diphenyl-1, 4-phenylenediamine, a grey or dark grey powder, is used as an antioxidant in rubber and oils, especially for tires in industry due to its colour and stability [ 8 ]. DPPD is one of the most frequently used and potent antioxidants.…”

Section: Introductionmentioning

confidence: 99%

Protective Effect of DPPD on Mercury Chloride-Induced Hepatorenal Toxicity in Rats

Nabil

Elshemy

Asem

et al. 2020

Journal of Toxicology

View full text Add to dashboard Cite

Mercury is a global environmental pollutant, accumulating mainly in the kidney and liver inducing hepatorenal toxicity, oxidative stress, and tissue damage. Oxidative stress is caused by an imbalance between free radicals’ production and cellular antioxidant defense systems. In the present study, we investigated the effect of N N′-diphenyl-1, 4-phenylenediamine (DPPD) antioxidant activity against mercury chloride- (HgCl2-) induced renal and hepatic toxicity. Thirty adult female Sprague Dawley rats were divided into three equal groups: the first group was injected with saline only and served as a control, the second group was injected with HgCl2, and the third group received DPPD + HgCl2 rats injected with HgCl2 without treatment showing a significant increase in alkaline phosphatase (ALP), aspartate aminotransferase (AST), alanine aminotransferase (ALT), urea, creatinine, and uric acids compared to control. Moreover, the second group showed a significant reduction in the activity of the antioxidant enzymes (superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GSH)) in addition to a marked increase in the malondialdehyde (MDA) content, histopathological alterations, collagen deposition, CD8%, CD4%, and TGF-β% in kidney and liver tissues compared with the control group. Treatment with DPPD showed significant recovery (p≤0.001) in all previous parameters and histopathological examination. In conclusion, we suggested that DPPD may have a promising antioxidant capacity, gives it the applicability to be used as a prophylactic agent against mercury-induced hepatorenal cytotoxicity in the future.

show abstract

An antioxidant, N,N′-diphenyl-p-phenylenediamine (DPPD), affects labor and delivery in rats: A 28-day repeated dose test and reproduction/developmental toxicity test

Cited by 43 publications

References 11 publications

In vitro cytocompatibility and blood compatibility of polysulfone blend, surface-modified polysulfone and polyacrylonitrile membranes for hemodialysis

In vitro cytocompatibility and blood compatibility of polysulfone blend, surface-modified polysulfone and polyacrylonitrile membranes for hemodialysis

Occurrence of Substituted p-Phenylenediamine Antioxidants in Dusts

Protective Effect of DPPD on Mercury Chloride-Induced Hepatorenal Toxicity in Rats

Contact Info

Product

Resources

About