An appraisal of CT pulmonary density mapping in normal subjects

Adams, H.; Bernard, M.; McConnochie, K.

doi:10.1016/s0009-9260(05)80245-4

Cited by 57 publications

(32 citation statements)

References 10 publications

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“…While, compared to Haraldsson et al study (9) , the gel density and CT number were decreased signi2icantly with addition of more polystyrene spheres, still they were higher than the corresponding values for normal human lung tissue, which ranges from −770 to −875 Houns2ield units (12) . The gel density could potentially be further lowered by adding of smaller polystyrene spheres.…”

Section: Discussioncontrasting

confidence: 62%

Basic investigation on performance of low-density polymer gel dosimeter

Pake

Takavar

Nedaie

et al. 2016

IJRR

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Section: Discussioncontrasting

confidence: 62%

Basic investigation on performance of low-density polymer gel dosimeter

Pake

Takavar

Nedaie

et al. 2016

IJRR

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“…However, this type of system tends to be labourious and time consuming. Automated objective techniques such as density thresholding [111,112] are critically dependent upon a clear dichotomy between normal and reduced lung density; while such a difference exists in emphysema, in constrictive bronchiolitis, particularly when admixed with interstitial disease, lung density representing disease is highly heterogeneous and automation of density scoring in this context has proved elusive. Thus, subjective visual scoring systems, sometimes semi-automated, are often favoured for quantitative studies of small airways disease.…”

Section: Morphological-functional Correlations In Constrictive Bronchmentioning

confidence: 99%

Small airways diseases: detection and insights with computed tomography

Dm¹

2001

Eur Respir J

146

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Diseases affecting the small airways are difficult to detect by traditional diagnostic tests. Widespread involvement is needed before symptoms and abnormalities on pulmonary function testing or chest radiography become apparent. Obstruction of the bronchioles may be detected indirectly by computed tomography (CT) because regional under-ventilation results in reduced perfusion which in turn is shown as a mosaic attenuation pattern of the lung parenchyma. When there is inflammation of the bronchioles with accompanying exudate, the airways may become directly visible on CT, for example in cases of diffuse panbronchiolitis.Quantification of the various morphological features of small airways disease is possible from CT images and this increased precision has aided investigations of structure/function relationships.An understanding of the pathology and microscopic distribution of disease in relation to the airways allows some prediction of the likely computed tomography appearances in this wide spectrum of conditions, and thus helps to refine the differential diagnosis.

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“…In addition to being evaluated visually, emphysematous changes on CT can be quantified objectively by measuring lung attenuation [11,12]. Lung attenuation values in normal subjects range from -770--875 Hounsfield units (HU) [13]. The density in emphysematous lung is low, and voxels with low attenuation values can be highlighted by the use of "density mask" software [11].…”

mentioning

confidence: 99%

The correlation of emphysema or airway obstruction with the risk of lung cancer: a matched case-controlled study

Kishi¹,

Gurney²,

Schroeder³

et al. 2002

Eur Respir J

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A matched case-controlled study was conducted to determine if airway obstruction or emphysema were associated with an increased risk of lung cancer.Lung cancer cases (n=24) were identified through a low-dose spiral computed tomography (CT) screening trial from 1,520 participants. Four controls without lung cancer were selected for each case from the participants and matched by sex, age and smoking history. Emphysema was assessed by quantitative CT analysis. Conditional logistic regression was employed to assess results of spirometry and CT quantitative analysis as potential risk factors for lung cancer.The likelihood of lung cancer was found to be significantly increased for those with forced expiratory volume in one second (FEV1) ¡40% of predicted. The results suggested that a lower percentage of predicted FEV1 was indicative of lung cancer. No compelling evidence was found to suggest that the percentage of emphysema was associated with lung cancer.These results suggest an increased risk of lung cancer associated with airway obstruction. However, percentage of emphysema as determined by computed tomography was not associated with an increased risk of lung cancer.

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An appraisal of CT pulmonary density mapping in normal subjects

Cited by 57 publications

References 10 publications

Basic investigation on performance of low-density polymer gel dosimeter

Basic investigation on performance of low-density polymer gel dosimeter

Small airways diseases: detection and insights with computed tomography

The correlation of emphysema or airway obstruction with the risk of lung cancer: a matched case-controlled study

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