An appraisal of emerging therapeutic targets for multiple sclerosis derived from current preclinical models

Dixit, Aakanksha; Savage, Hannah; Greer, Judith M.

doi:10.1080/14728222.2023.2236301

Cited by 2 publications

(2 citation statements)

References 152 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Thus, the research community working on MS cannot yet avoid taking advantage of rodent' models for proper in vivo relevant preclinical research. Several models are available; some of them are inducible, while others are genetic mouse models that can still help dissect MS pathobiology [21].…”

Section: Preclinical Models Of Msmentioning

confidence: 99%

CNS Resident Innate Immune Cells: Guardians of CNS Homeostasis

Muzio,

Perego

2024

IJMS

View full text Add to dashboard Cite

Although the CNS has been considered for a long time an immune-privileged organ, it is now well known that both the parenchyma and non-parenchymal tissue (meninges, perivascular space, and choroid plexus) are richly populated in resident immune cells. The advent of more powerful tools for multiplex immunophenotyping, such as single-cell RNA sequencing technique and upscale multiparametric flow and mass spectrometry, helped in discriminating between resident and infiltrating cells and, above all, the different spectrum of phenotypes distinguishing border-associated macrophages. Here, we focus our attention on resident innate immune players and their primary role in both CNS homeostasis and pathological neuroinflammation and neurodegeneration, two key interconnected aspects of the immunopathology of multiple sclerosis.

show abstract

Section: Preclinical Models Of Msmentioning

confidence: 99%

CNS Resident Innate Immune Cells: Guardians of CNS Homeostasis

Muzio,

Perego

2024

IJMS

View full text Add to dashboard Cite

show abstract

“…While the release of these factors is intended to prevent further tissue damage, they are also toxic to neurons, and chronic microglial activation is one of the major contributing factors to the pathogenesis of neurodegenerative disorders (54,137). For example, activated microglia has been shown to play a crucial role in the pathogenesis of multiple sclerosis (MS) (54)(55)(56)(57). Microglia associated inflammation within CNS results in the demyelination of neurons in MS patients (54,57).…”

Section: Autophagy and Neuroinflammation In Glia Cellsmentioning

confidence: 99%

Epigenetic regulation of autophagy in neuroinflammation and synaptic plasticity

Bai,

Keyser,

Zhang

et al. 2024

Front. Immunol.

View full text Add to dashboard Cite

Autophagy is a conserved cellular mechanism that enables the degradation and recycling of cellular organelles and proteins via the lysosomal pathway. In neurodevelopment and maintenance of neuronal homeostasis, autophagy is required to regulate presynaptic functions, synapse remodeling, and synaptic plasticity. Deficiency of autophagy has been shown to underlie the synaptic and behavioral deficits of many neurological diseases such as autism, psychiatric diseases, and neurodegenerative disorders. Recent evidence reveals that dysregulated autophagy plays an important role in the initiation and progression of neuroinflammation, a common pathological feature in many neurological disorders leading to defective synaptic morphology and plasticity. In this review, we will discuss the regulation of autophagy and its effects on synapses and neuroinflammation, with emphasis on how autophagy is regulated by epigenetic mechanisms under healthy and diseased conditions.

show abstract

An appraisal of emerging therapeutic targets for multiple sclerosis derived from current preclinical models

Cited by 2 publications

References 152 publications

CNS Resident Innate Immune Cells: Guardians of CNS Homeostasis

CNS Resident Innate Immune Cells: Guardians of CNS Homeostasis

Epigenetic regulation of autophagy in neuroinflammation and synaptic plasticity

Contact Info

Product

Resources

About