An approach to reduction of uncertainties in internal doses reconstructed for the Techa river population

Shagina, N. B.; Толстых, Е. И.; Bougrov, N. G.; Zalyapin, V.I.; Anspaugh, L.R.; Napier, Bruce A.

doi:10.1093/rpd/ncm410

Cited by 27 publications

(14 citation statements)

References 7 publications

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“…The dose-reconstruction process is extensively based on the results of postmortem measurements of 90 Sr concentration in bone samples obtained in 1951-1993, the results of in vivo measurements of surface-beta activity of teeth using tooth-beta counters , and on measurements of 137 Cs and 90 Sr body burden in a whole body counter . Mean cumulative RBM dose in 1956 was 333.6 ± 4.6 mGy (SD = 259.9 mGy, max = 1151 mGy) (Napier et al 2001;Degteva et al 2006Degteva et al , 2007. The internal exposure was a determinative factor for about 80% of the riverside population (lower and middle reaches of the Techa).…”

Section: Description Of Population and Clinical Methodsmentioning

confidence: 97%

“…The internal exposure was a determinative factor for about 80% of the riverside population (lower and middle reaches of the Techa). The residents of the upper reaches were exposed both internally and externally, and the levels of each type of exposure were comparable (Degteva et al 2007;Anspaugh et al 2006).…”

Section: Description Of Population and Clinical Methodsmentioning

confidence: 99%

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Early hematopoiesis inhibition under chronic radiation exposure in humans

Akleyev

Akushevich

Dimov

et al. 2010

Radiat Environ Biophys

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The major goal of this study was to identify and quantitatively describe the association between the characteristics of chronic (low-dose rate) exposure to (low LET) ionizing radiation and cellularity of peripheral blood cell lines. About 3,200 hemograms (i.e., spectra of blood counts) obtained over the years of maximal exposure to ionizing radiation (1950)(1951)(1952)(1953)(1954)(1955)(1956)) for inhabitants of the Techa River were used in analyses. The mean cumulative red bone marrow dose (with standard errors), calculated using Techa River Dosimetry System-2000, was 333.6 ± 4.6 mGy (SD = 259.9 mGy, max = 1151 mGy) to the year 1956. The statistical approach included both empirical methods for estimating frequencies of cytopenic states of the investigated blood cell lines (e.g. neutrophile, platelets, erythrocyte, etc.), and regression methods, including generalized linear models and logistic regressions which allowed taking into account confounding factors (e.g., attained age, age at maximal exposure, presence of concomitant diseases, and demographic characteristics). The results of the analyses demonstrated hematopoiesis inhibition manifested by a decrease in peripheral blood cellularity and an increase in the frequency of cytopenia in all blood cell lines (leukocytes, including lymphocytes, monocytes, neutrophiles, as well as platelets and erythrocytes). The intensity of hematopoiesis inhibition in the period of maximal exposures is determined by the combined influence of the dose rate and cumulative dose. The contribution of specific confounding factors was quantified and shown to be much less important than dose characteristics. The best predictor among dose characteristics was identified for each blood cell line. A 2-fold increase in dose rate is assumed to be a characteristic of radiosensitivity and a quantitative characteristic of the effect.

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Section: Description Of Population and Clinical Methodsmentioning

confidence: 97%

Section: Description Of Population and Clinical Methodsmentioning

confidence: 99%

Early hematopoiesis inhibition under chronic radiation exposure in humans

Akleyev

Akushevich

Dimov

et al. 2010

Radiat Environ Biophys

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“…Recent improvements are described in (Shagina et al , 2003; Degteva et al , 2007, 2009; Tolstykh et al , 2011; Degteva et al , 2012; Shagina et al , 2012a, 2012b). …”

Section: Methodsmentioning

confidence: 99%

Leukaemia incidence in the Techa River Cohort: 1953–2007

et al. 2013

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Background:Little is known about leukaemia risk following chronic radiation exposures at low dose rates. The Techa River Cohort of individuals residing in riverside villages between 1950 and 1961 when releases from the Mayak plutonium production complex contaminated the river allows quantification of leukaemia risks associated with chronic low-dose-rate internal and external exposures.Methods:Excess relative risk models described the dose–response relationship between radiation dose on the basis of updated dose estimates and the incidence of haematological malignancies ascertained between 1953 and 2007 among 28 223 cohort members, adjusted for attained age, sex, and other factors.Results:Almost half of the 72 leukaemia cases (excluding chronic lymphocytic leukaemia (CLL)) were estimated to be associated with radiation exposure. These data are consistent with a linear dose response with no evidence of modification. The excess relative risk estimate was 0.22 per 100 mGy. There was no evidence of significant dose effect for CLL or other haematopoietic malignancies.Conclusion:These analyses demonstrate that radiation exposures, similar to those received by populations exposed as a consequence of nuclear accidents, are associated with long-term dose-related increases in leukaemia risks. Using updated dose estimates, the leukaemia risk per unit dose is about half of that based on previous dosimetry.

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“…The uncertainty in each parameter can be described by a standard statistical distribution. Further, more detailed analysis of uncertainty in the doses being calculated for the TRDS is the subject of continuing work; some approaches were described in Degteva et al (2007).…”

Section: Approaches To Evaluation Of Uncertainties In the Reference 9mentioning

confidence: 99%

Reconstruction of Long-Lived Radionuclide Intakes for Techa Riverside Residents: Strontium-90

Толстых¹,

Дегтева²,

Peremyslova³

et al. 2011

Health Physics

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Releases of radioactive materials from the Mayak Production Association in 1949-1956 resulted in contamination of the Techa River; a nuclide of major interest was 90Sr, which downstream residents consumed with water from the river and with milk contaminated by cows' consumption of river water and contaminated pasture. Over the years, several reconstructions of dose have been performed for the approximately 30,000 persons who make up the Extended Techa River Cohort. The purpose of the study described here was to derive a revised reference-90Sr-intake function for the members of this cohort. The revision was necessary because recently discovered data have provided a more accurate description of the time course of the releases, and more is now known about the importance of the pasture grass-cow-milk pathway for the members of this cohort. The fundamental basis for the derivation of the reference-90Sr-intake function remains the same: thousands of measurements of 90Sr content in bone with a special whole-body counter, thousands of measurements of beta-activity of front teeth with a special tooth-beta counter, and a variety of other measurements, including post mortem measurements of 90Sr in bone, measurements of 90Sr in cow's milk, and measurements of beta activity in human excreta. Results of the new analyses are that the major intake started in September 1950 and peaked somewhat later than originally postulated. However, the total intake for adult residents has not changed significantly. For children of some birth years, the intake and incorporation of Sr in bone tissue have changed substantially.

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An approach to reduction of uncertainties in internal doses reconstructed for the Techa river population

Cited by 27 publications

References 7 publications

Early hematopoiesis inhibition under chronic radiation exposure in humans

Early hematopoiesis inhibition under chronic radiation exposure in humans

Leukaemia incidence in the Techa River Cohort: 1953–2007

Reconstruction of Long-Lived Radionuclide Intakes for Techa Riverside Residents: Strontium-90

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