An approach towards the C1–C16 fragment of antineoplastic macrolide bryostatins by kinetic resolution of a racemic terminal epoxide using Jacobsen's catalyst

Yadav, J. S.; Bandyopadhyay, Ananda K.; Kunwar, A. C.

doi:10.1016/s0040-4039(01)00841-3

Cited by 45 publications

(10 citation statements)

References 42 publications

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“…Compound 220 was formed as a single product when a model tandem WHE olefination-Michael addition sequence was applied to hemiacetal 217. Very recently, Yadav and coworkers 114 have further developed these ideas and reported an even more elaborate WHE strategy which connects two highly decorated bryostatin A and B-ring synthons together (see section 6.10), emphasising the soundness of such an approach for constructing this domain. Other work along these lines is awaited with interest.…”

Section: Model Studies On the Bryostatin B-ring (1991) 78amentioning

confidence: 99%

The chemistry and biology of the bryostatin antitumour macrolides

Hale¹,

Hummersone²,

Manaviazar³

et al. 2002

Nat. Prod. Rep.

187

140

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Section: Model Studies On the Bryostatin B-ring (1991) 78amentioning

confidence: 99%

The chemistry and biology of the bryostatin antitumour macrolides

Hale¹,

Hummersone²,

Manaviazar³

et al. 2002

Nat. Prod. Rep.

187

140

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show abstract

“…19 Additionally, a formal total synthesis of bryostatin 7 was reported by Hale and colleagues in 2006. 20 Several additional groups have also made noteworthy contributions to this field, including those of Thomas, 21 Vandewalle, 22 Roy, 23 Burke, 24 Krische, 25 Hoffmann, 26 Yadav, 27 and others. 28 …”

mentioning

confidence: 99%

Total Synthesis of Bryostatin 9

2011

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“…Several additional groups have contributed notably to this field, including those of Thomas, [44] Vandewalle, [45] Roy, [46] Burke, [47] Krische, [48] Hoffmann, [49] Yadav, [50] and others. Impressive progress continues to be made that could eventually impact clinical supply.…”

Section: Resultsmentioning

confidence: 99%

Translating Nature’s Library: The Bryostatins and Function‐Oriented Synthesis

Wender

Loy

Schrier

2011

Israel Journal of Chemistry

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We review in part our computational, design, synthesis, and biological studies on a remarkable class of compounds and their designed analogs that have led to preclinical candidates for the treatment of cancer, a first-in-class approach to Alzheimer's disease, and a promising strategy to eradicate HIV/AIDS. Because these leads target, in part, protein kinase C (PKC) isozymes, they have therapeutic potential even beyond this striking set of therapeutic indications. This program has given rise to new synthetic methodology and represents an increasingly important direction of synthesis focused on achieving function through synthesis-informed design (function-oriented synthesis).

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An approach towards the C1–C16 fragment of antineoplastic macrolide bryostatins by kinetic resolution of a racemic terminal epoxide using Jacobsen's catalyst

Cited by 45 publications

References 42 publications

The chemistry and biology of the bryostatin antitumour macrolides

The chemistry and biology of the bryostatin antitumour macrolides

Total Synthesis of Bryostatin 9

Translating Nature’s Library: The Bryostatins and Function‐Oriented Synthesis

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