An aqueous extract of Lantana camara attenuates seizures, memory impairment, and anxiety in kainate-treated mice: Evidence of GABA level, oxidative stress, immune and neuronal loss modulation

An aqueous extract of Khaya senegalensis (Desv.) A. Juss. (Meliaceae) prevents seizures and reduces anxiety in kainate-treated rats: modulation of GABA neurotransmission, oxidative stress, and neuronal loss in the hippocampus

“…These results in the elevated plus maze test were confirmed in the open field test with an increase in the number of crossings and time spent in the inner zone. These results indicate an anxiolytic-like effect of the extract of K. senegalensis against generalized anxiety ( Moto et al., 2018 ; Kandeda et al., 2022 ). This effect could be mediated by an interaction of the extract with GABAergic signaling or downregulation of glutamate neurotransmission in the amygdala ( Ryazantseva et al., 2020 ; Negrete-Díaz et al., 2021 ).…”

“…In rodents, anxiety-like behaviors are tested using several paradigms such as elevated plus maze and open field ( Rodgers and Dalvi, 1997 ; Umpierre et al., 2014 ; Smolensky et al., 2019 ). The elevated plus maze and open field tests are therefore used to assess the sensitivity of medications to generalized anxiety ( Rodgers and Dalvi, 1997 ; Seibenhener and Michael, 2015 ; Kandeda et al., 2021a ), a common form of anxiety in patients with TLE ( Özyurt et al., 2015 ; Nogueira et al., 2017 ; Kandeda et al., 2022 ). In the present study, 48 h following the end of treatments, animals of the KA + DW group exhibited generalized anxiety-like behavior compared to the DW + DW group.…”

“…This test is based on the study of spontaneous behavior in animals ( Rodgers and Dalvi, 1997 ). The experiment was carried out in the laboratory between 20 h and 24 h of the night because animals are hypoactive during this period of the day ( Kandeda et al., 2022 ). The test consisted of placing each rat in the center of the device, facing an open arm for free exploration.…”

“…As a result, epilepsy represents the second most common reason for consultation in neurology (16%) in Cameroon, clearly making it a major public health concern ( Mapoure et al., 2015 ; Angwafor et al., 2021 ; Morin et al., 2021 ). Of all types of epilepsy, temporal lobe epilepsy (TLE) accounts for 70–80% of adult epilepsies and is highly drug-resistant ( Lévesque et Avoli, 2013 ; D'Alessio et al., 2020 ; Kandeda et al., 2021b ; Kandeda et al., 2022 ).…”

“…In particular, an impairment of neurotransmission mediated by GABAergic signaling is associated with the development of anxiety disorders ( Vazquez and Devinsky, 2003 ; Beyenburg et al., 2005 ; Lima et al., 2021 ). In rodents, TLE can be modeled by systemic injection of kainate, an analog of glutamate ( Ben-Ari, 1985 ; Lévesque and Avoli, 2013 ; Kandeda et al., 2022 ). In fact, kainate activates kainate/AMPA receptors through a form of permanent stimulation called excitotoxicity ( Lévesque and Avoli, 2013 ; Wang et al., 2020 ; Landucci et al., 2021 ).…”