2018
DOI: 10.1101/408450
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An Artificial Intelligence Workflow for Defining Host-Pathogen Interactions

Abstract: For image-based infection biology, accurate unbiased quantification of host-pathogen interactions is essential, yet often performed manually or using limited enumeration employing simple image analysis algorithms based on image segmentation. Host protein recruitment to pathogens is often refractory to accurate automated assessment due to its heterogeneous nature. An intuitive intelligent image analysis program to assess host protein recruitment within general cellular pathogen defense is lacking. We present HR… Show more

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Cited by 4 publications
(2 citation statements)
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“…The existing cell analytical platforms, such as CellProfiler and ImageJ, etc., have limited features for the analysis of phase contrast images [ 10 ] due to the complex image features and difficulty of detecting cell populations. In the last few years, deep learning methods such as CNNs have shown remarkable performances for a wide range of computer vision tasks.…”
Section: Introductionmentioning
confidence: 99%
“…The existing cell analytical platforms, such as CellProfiler and ImageJ, etc., have limited features for the analysis of phase contrast images [ 10 ] due to the complex image features and difficulty of detecting cell populations. In the last few years, deep learning methods such as CNNs have shown remarkable performances for a wide range of computer vision tasks.…”
Section: Introductionmentioning
confidence: 99%
“…14 Historically, the field of AI originates from an attempt to create fundamental and applied basics for machines with "intelligent properties". 15 ML, often considered an AI subfield, has significantly facilitated AI by providing a tangible toolset. Conversely, the traction some ML algorithms like artificial neural networks have gained in recent years may be to a larger extent attributed to the effort to make progress in AI.…”
Section: Introductionmentioning
confidence: 99%