This work is on the application of Artificial Neural Network (ANN) to study the effects of using palm kernel shells (PKS) as aggregates on the compressive strength of concrete. ANN with an input neuron of 6 factors, 2 hidden layers, 18 and 12 each and 1 output neuron for the compressive strength were used for this work. A mix ratio of 1: 1.5: 3 with cement content of 382kN/m 3 , water-cement ratio of 0.55 were used for the work, and cured for 90 days. A total of fifty concrete mixes containing PKS in various proportions of 0 % to 40 % by wt. of the coarse aggregate were used for the training. For the validation and testing ten mixes were used.. Therefore, sixty (60) data sets were generated for which approximately eighty (80) percent was used for the training, and twenty (20) percent for the validation and test. The results showed that the distribution characteristic of PKS-concrete using ANN is adequate for the prediction of compressive strength. The predicted and experimental results are strongly correlation, with a model equation with an intercept, 1.5 and a slope of 0.93. The characteristic distribution results of the predicted with the experimental showed that the parameter estimates (ANN and Statistics), are within the 95 % confidence limits (CI), and very significant (P<0.05).