An assessment of antioxidant status in patients with carbon monoxide poisoning

Zengin, Suat; Al, Behçet; B, Can; Can, Basri; Örkmez, Mustafa; Taşkın, Abdullah; Lök, Uğur; Gulen, Bediha; Yıldırım, Cuma; Taysı, Seyithan

doi:10.5847/wjem.j.issn.1920-8642.2014.02.002

Cited by 11 publications

(7 citation statements)

References 25 publications

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“…In the study of Zengin et al in order to examine CO intoxication antioxidant levels as compared to the study group with a healthy control group. 18 These researchers have detected that TAR, PON, ARES and thiol results decreased, that is to say, antioxidant condition decreased in patients with CO intoxication. In our study, native and total thiol levels which were indicators of antioxidants, decreased, disulphide which was an indicator of oxidation increased.…”

Section: Discussionmentioning

confidence: 98%

Evaluation Of Thiol Disulphide Homeostasis And Neutrophile Lymphocyte Ratio In Carbon Monoxide Intoxication:

Tanrıverdi¹,

Yüzbaşıoğlu²,

Haydar³

et al. 2020

Ankara Med J

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Bu çalışmanın amacı acil servise karbon monoksit zehirlenmesi nedeniyle başvuran hastalarda oksidatif stres markerlarından olan thiol/disülfit homeostazis parametreleri ile Nötrofil-Lenfosit (NLO) beraber kullanımının tanı açısından yararlı olup olmadığını araştırmaktır. Materyal ve Metot: Çalışma 01.01.2014 ile 01.03.2015 tarihleri arasında acil servise başvuran ve çalışmaya alınan 45 hasta ve kontrol grubu olarak belirlenen 40 sağlıklı kişi ile prospektif olarak yapıldı. Erel ve Neşelioğlu tarafından yeni geliştirilen bir metot ile oksidatif stres markerı olan thiol/disülfit homeostazis parametreleri (Thiol, disülfit, disülfit/native thiol, disülfit/total thiol, native thiol/total thiol) ile NLO hasta ve kontrol grubunda çalışıldı. Bulgular: Karbonmonoksit zehirlenmesi olanlarda kontrol grubuna göre, NT, TT, index 3 ve NLO oranlarında anlamlı farklılık tespit edildi. NT, TT ve index 3 hasta grubunda daha düşük, NLO ortalama değerleri daha yüksek bulundu (sırasıyla p =0,005; < 0,001; < 0,032 ve < 0,001). Sonuç: NLO ile thiol/disülfit homeostasis parametrelerinin karbonmonoksit zehirlenmesi tanısında beraber kullanılması bu hastalarda tanının konulması açısından faydalıdır.

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Section: Discussionmentioning

confidence: 98%

Evaluation Of Thiol Disulphide Homeostasis And Neutrophile Lymphocyte Ratio In Carbon Monoxide Intoxication:

Tanrıverdi¹,

Yüzbaşıoğlu²,

Haydar³

et al. 2020

Ankara Med J

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“…[ 1 ] ACOP can also lead to delayed encephalopathy after ACOP (DEACMP). [ 2 , 3 ] Coma duration is one of the objective predictors of poor prognosis in emergency patients with ACOP. Therefore, evaluating the degree of consciousness impairment in patients with ACOP, especially the duration, is crucial to understand the patient's condition, prevent related complications, and evaluate patients’ prognosis.…”

Section: Introductionmentioning

confidence: 99%

“…The formation of carboxyhemoglobin reduces the blood's oxygen-carrying capacity, causing tissue hypoxia and leading to ischemic stroke [1] . ACOP can also lead to delayed encephalopathy after ACOP (DEACMP) [2,3] . Coma duration is one of the objective predictors of poor prognosis in emergency patients with ACOP.…”

Section: Introductionmentioning

confidence: 99%

Serum NSE and S100B protein levels for evaluating the impaired consciousness in patients with acute carbon monoxide poisoning

Zhang¹,

Zhao²,

Hao

et al. 2021

Medicine

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The aim of this study was to investigate the associations between the levels of neuron-specific enolase (NSE) and S100B protein and coma duration, and evaluate the optimal cut-off values for prediction coma duration ≥ 72 hours in patients with acute carbon monoxide poisoning (ACOP). A total of 60 patients with ACOP were divided into 3 following groups according to their status of consciousness and coma duration at admission: Awake group [Glasgow Coma Scale score (GCS score) ≥ 13 points], Coma < 72 hours group (GCS score < 13 points and coma duration < 72 h), and Coma ≥ 72 hours group (GCS score < 13 points and coma duration ≥ 72 h). The levels of serum NSE and S100B protein were measured after admission. There were significant differences in GCS score, carbon monoxide (CO) exposure time, NSE, and S100B levels between the Coma ≥ 72 h group and the Awake group, and between the Coma < 72 h group and the Awake group. Significant differences in GCS score, NSE, and S100B levels were also found between Coma ≥ 72 h group and Coma < 72 h group. Correlation analysis showed that NSE and S100B were positively correlated ( r s = 0.590, P < .01); NSE and S100B were negatively correlated with GCS score ( r s = -0.583, r s = -0.590, respectively, both P < .01). The areas under the curve (AUCs) of NSE, S100B, and GCS score to predict the coma duration ≥ 72 hours were 0.754, 0.791, and 0.785, respectively. Pairwise comparisons did not show differences among the 3 groups (all P > .05). The sensitivity and specificity of NSE prediction with a cut-off value of 13 μg/L were 80% and 64%, respectively, and those of S100B prediction with a cut-off value of 0.43 μg/L were 70% and 88%, respectively. The NSE and S100B protein levels were significantly correlated with the degree of impaired consciousness and had the same clinical value in predicting coma duration of ≥ 72 hours in patients with ACOP.

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“…Lipid hydroperoxide (LOOH) is an important marker of OS formed from unsaturated phospholipids, glycolipids and cholesterol. Ceruloplasmin (Cp) is an acute-phase plasma protein with antioxidant property (11). On account of the complex formation with ferroportin I, the membrane-bound Cp found in astrocytes participates in regulation of iron levels in the prevention of free radical reactions (12).…”

Section: Introductionmentioning

confidence: 99%

“…On account of the complex formation with ferroportin I, the membrane-bound Cp found in astrocytes participates in regulation of iron levels in the prevention of free radical reactions (12). Finally, total sulfhydryl (-SH) groups are very important for maintaining the cellular redox status (11).…”

Section: Introductionmentioning

confidence: 99%

Oxidative Stress in Endometrial Flushing Fluid of Patients with Polycystic Ovary Syndrome, Endometrioma and Uterine Leiomyoma: Comparison with Healthy Controls

Demir¹,

İnce²,

Yılmaz

et al. 2020

Gynecol Obstet Reprod Med

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OBJECTIVE: Polycystic ovary syndrome, myoma uteri and endometrioma are frequently seen gynecologic problems and all three diseases may cause infertility. Aim of this cross-sectional study was to compare total antioxidant status, ceruloplasmin, total sulfhydryl , total oxidant status, lipid hydroperoxide and oxidative stress index levels in endometrial flushing fluid of patients with Polycystic ovary syndrome (n=20), uterine leiomyoma (n=20), endometrioma (n=19), and healthy women (n=20).STUDY DESIGN: We compare endometrial flushing fluid of patients with polycystic ovary syndrome (n=20), uterine leiomyoma (n=20), endometrioma (n=19) and healthy women (n=20). Endometrial flushing fluid samples were collected during the implantation window of all women.RESULTS: Mean age of groups was 28.90±5.45, 37.25±2.73, 32.84±6.62 and 32.15±5.18 in Polycystic ovary syndrome, myoma uteri, endometrioma and control groups, respectively (p<0.05). Mean total antioxidant status, ceruloplasmin and total sulfhydryl levels indicating antioxidant state were comparable between Polycystic ovary syndrome, myoma uteri, endometrioma and control groups (p=0.806, p=0.156, p=0.328 respectively for markers). Similarly, oxidant state-related markers didn’t differ significantly between 4 groups (p=0.090 for total oxidant status, p=0.087 for lipid hydroperoxide, p=0.312 for oxidative stress index).CONCLUSION: Endometrial flushing fluid total antioxidant status, total oxidant status, lipid hydroperoxide, ceruloplasmin, and total sulfhydryl levels during implantation window didn’t differ between women with Polycystic ovary syndrome, uterine leiomyoma, endometrioma, and healthy controls.

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An assessment of antioxidant status in patients with carbon monoxide poisoning

Cited by 11 publications

References 25 publications

Evaluation Of Thiol Disulphide Homeostasis And Neutrophile Lymphocyte Ratio In Carbon Monoxide Intoxication:

Evaluation Of Thiol Disulphide Homeostasis And Neutrophile Lymphocyte Ratio In Carbon Monoxide Intoxication:

Serum NSE and S100B protein levels for evaluating the impaired consciousness in patients with acute carbon monoxide poisoning

Oxidative Stress in Endometrial Flushing Fluid of Patients with Polycystic Ovary Syndrome, Endometrioma and Uterine Leiomyoma: Comparison with Healthy Controls

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