An Assessment of Asymptomatic Bacteriuria among Women with Vesico-Vaginal Fistula in South-Eastern Nigeria

Adeoye, Ileogben Sunday; Oladeinde, Oladapo Babatunde; Uneke, Jesse; Adeoye, Julie

doi:10.3126/nje.v1i2.5141

Cited by 8 publications

(21 citation statements)

References 27 publications

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“…In general, the overall prevalence of UTI in the present study was 58.1%, which is almost similar with other report from India (60%) [ 19 ]. But the present finding of UTI was lower than other studies from Libya (65.7% ) [ 20 ] and Nigeria (76.1%) [ 21 ].…”

Section: Discussioncontrasting

confidence: 99%

Urinary tract infection among fistula patients admitted at Hamlin fistula hospital, Addis Ababa, Ethiopia

Dereje

Woldeamanuel

et al. 2017

BMC Infect Dis

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BackgroundUrinary Tract Infection (UTI) causes a serious health problem and affects millions of people worldwide. Patients with obstetric fistula usually suffer from incontinence of urine and stool, which can predispose them to frequent infections of the urinary tract. Therefore the aim of this study was to determine the etiologic agents, drug resistance pattern of the isolates and associated risk factor for urinary tract infection among fistula patients in Addis Ababa fistula hospital, Ethiopia.MethodsAcross sectional study was conducted from February to May 2015 at Hamlin Fistula Hospital, Addis Ababa, Ethiopia. Socio-demographic characteristics and other UTI related risk factors were collected from study participants using structured questionnaires. The mid-stream urine was collected and cultured on Cysteine lactose electrolyte deficient agar and blood agar. Antimicrobial susceptibility was done by using disc diffusion method and interpreted according to Clinical and Laboratory Standards Institute (CLSI). Data was entered and analyzed by using SPSS version 20.ResultsOut of 210 fistula patients investigated 169(80.5%) of the patient were younger than 25 years. Significant bacteriuria was observed in 122/210(58.1%) and 68(55.7%) of the isolates were from symptomatic cases. E.coli 65(53.7%) were the most common bacterial pathogen isolated followed by Proteus spp. 31(25.4%). Statistical Significant difference was observed with history of previous UTI (P = 0.031) and history of catheterization (P = 0.001). Gram negative bacteria isolates showed high level of resistance (>50%) to gentamicin and ciprofloxacin, while all gram positive bacteria isolated were showed low level of resistance (20–40%) to most of antibiotic tested.ConclusionsThe overall prevalence of urinary tract infection among fistula patient is 58.1%. This study showed that the predominant pathogen of UTI were E.coli followed by Proteus spp. It also showed that amoxicillin-clavulanic acid was a drug of choice for urinary tract bacterial pathogens.

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Section: Discussioncontrasting

confidence: 99%

Urinary tract infection among fistula patients admitted at Hamlin fistula hospital, Addis Ababa, Ethiopia

Dereje

Woldeamanuel

et al. 2017

BMC Infect Dis

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“…In the present study, the overall prevalence of UTI was 28 (52.8%) which is almost similar with other report in Nigeria (76.1%) [17]. But this finding was higher than other studies in Kenya 8.0% [18] and Nigeria 11 (9.2%) [19]. The prevalence of UTI in the present study was also higher than another reports from pregnant women in the study area [20], Addis Ababa Ethiopia [21] and Tanzania [22].…”

Section: Discussionsupporting

confidence: 89%

Urinary tract infection among obstetric fistula patients at Gondar University Hospital, Northwest Ethiopia

et al. 2014

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BackgroundMany women die from complications related to pregnancy and childbirth. In developing countries particularly in sub-Saharan Africa and Asia, where access to emergency obstetrical care is often limited, obstetric fistula usually occurs as a result of prolonged obstructed labour. Obstetric fistula patients have many social and health related problems like urinary tract infections (UTIs). Despite this reality there was limited data on prevalence UTIs on those patients in Ethiopia. Therefore, the aim of this study was to determine the prevalence, drug susceptibility pattern and associated risk factors of UTI among obstetric fistula patients at Gondar University Hospital, Northwest Ethiopia.MethodsA cross sectional study was conducted from January to May, 2013 at Gondar University Hospital. From each post repair obstetric fistula patients, socio-demographic and UTIs associated risk factors were collected by using a structured questionnaire. After the removal of their catheters, the mid-stream urine was collected and cultured on CLED. After overnight incubation, significant bacteriuria was sub-cultured on Blood Agar Plate (BAP) and MacConkey (MAC). The bacterial species were identified by series of biochemical tests. Antibiotic susceptibility test was done by disc diffusion method. Data was entered and analyzed by using SPSS version 20.ResultsA total of 53 post repair obstetric fistula patients were included for the determination of bacterial isolate and 28 (52.8%) of them had significant bacteriuria. Majority of the bacterial isolates, 26 (92.9%), were gram negative bacteria and the predominant ones were Citrobacter 13 (24.5%) and E. coli 6 (11.3%). Enterobacter, E.coli and Proteus mirabilis were 100% resistant to tetracycline. Enterobacter, Proteus mirabilis, Klebsella pneumonia, Klebsella ozenae and Staphylococcus aureus were also 100% resistant to ceftriaxone.ConclusionThe prevalence of bacterial isolates in obstetric fistula patients was high and majority of the isolates were gram negative bacteria. Even thought the predominant bacterial isolates were Citrobacter and E. coli, all of the bacterial isolates had multiple antibiotic resistance patterns which alert health profession to look better treatment for these patients.

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“…Similar organisms as obtainable in this study have also been implicated as microorganisms associated with urogenital tract of VVF patients in North-West Nigeria. 5 In another study, Adaoye et al, 17 also reported similar pathogens as causative factors in asymptomatic bacteriuria amongst women with VVF. The antimicrobial susceptibility test results of K. pneumoniae isolated from urine samples of presurgery VVF patients showed that some of the most frequently used antibiotics including cotrimoxazole, tetracycline, amoxicillin, amoxicillin-clavulanic acid, ofloxacin and cefuroxime encountered resistance levels in excess of 50 % to all the K. pneumoniae isolates with the exception of ofloxacin where the resistance level was 44 %.…”

Section: Discussionmentioning

confidence: 99%

“…And these results concur with those of other researchers in Nigeria who reported varying levels of resistance and susceptibility patterns amongst bacterial organisms isolated from urine samples of pre-and post-surgery VVF patients. 5,17 CONCLUSION: Conclusively, this study has presumptively shown that K. pneumoniae, E. coli, S. pyogenes and S. aureus are common bacterial isolates prevalent in women with VVF conditions. And the antibiogram of these organisms to various conventional antibiotics showed that the bacteria exhibit varying levels of resistance.…”

Section: Discussionmentioning

confidence: 99%

“…Similar findings regarding the antimicrobial susceptibility/resistance patterns of E. coli and K. pneumoniae isolates from VVF patients have also been reported by other researchers. 5,17 All the S. pyogenes isolates from urine samples of pre-and post-surgery VVF patients were found to be completely resistant to imipenem as was obtainable in K. pneumoniae and E. coli isolates. S. pyogenes isolates from pre-surgery VVF patients were found to be resistant to cefuroxime, nitrofurantoin, cotrimoxazole, tetracycline and amoxicillin.…”

Section: Discussionmentioning

confidence: 99%

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2016

IJPSR

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ABSTRACT:Vesicovaginal fistula (VVF) is an abnormal fistulous tract that extends between the bladder and the vagina -thus allowing the continuous involuntary discharge of urine into the vaginal vault of the affected patient. This study evaluated presumptively the prevalence and antibiogram of pathogenic bacteria isolated from pre-and postsurgery VVF patients. Urine samples were collected in duplicates from the VVF patients; and these were bacteriologically analyzed using cysteine lactose electrolyte deficient (CLED) agar, MacConkey agar and blood agar. Susceptibility studies were carried out on the isolated pathogens using the disk diffusion method. Klebsiella pneumoniae, Escherichia coli, S. pyogenes and S. aureus were the most isolated bacteria from the urine samples of pre-and post-surgery VVF patients. The organisms showed highest levels of resistance to ceftazidime, cotrimoxazole, amoxicillin, nitrofurantoin, cefuroxime, amoxicillin-clavulanic acid and tetracycline. With the exception of some S. aureus isolates, all the organisms including K. pneumoniae, E. coli and S. aureus were completely resistant to imipenem. However, gentamicin, ciprofloxacin, and ofloxacin showed appreciable levels of antimicrobial efficacy against the E. coli, K. pneumoniae, S. pyogenes and S. aureus isolates from both the pre-and post-surgery VVF patients. The complications of UTI in VVF patients necessitate the need to back up treatment with proper susceptibility studies. Our study has shown that the isolated organisms are resistant to some commonly used drugs. Thus it is vital to make antimicrobial stewardship a vital part of VVF management in our hospitals so that antibiotic therapy for such affected patients can be properly guided.

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An Assessment of Asymptomatic Bacteriuria among Women with Vesico-Vaginal Fistula in South-Eastern Nigeria

Cited by 8 publications

References 27 publications

Urinary tract infection among fistula patients admitted at Hamlin fistula hospital, Addis Ababa, Ethiopia

Urinary tract infection among fistula patients admitted at Hamlin fistula hospital, Addis Ababa, Ethiopia

Urinary tract infection among obstetric fistula patients at Gondar University Hospital, Northwest Ethiopia

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