An assessment of changes in the magnesium level during gynecological abdominal surgeries

Abstract

Background: Magnesium (Mg) is the fourth most common cation in the human body and the second most intracellular cation after potassium. It has a fundamental role in several vital functions. As this essential ion is not measured in routine chemistry panels, little is known about its alterations during intraoperative time. Aim: The present study was designed to determine the negative eff ects of postoperative hypomagnesemia during and after surgeries. Subject and Methods: This study was a descriptive interventional study involving 74 patients. All patients underwent gynecological abdominal surgeries, and anesthesia protocols were standardized to comprise general and spinal anesthesia. All the patients were aged between 25 and 45 years, with ASA class I and II. Their total serum Mg level was measured 1 h before and 2 h after the surgery. The total serum Mg, calcium, and albumin level were measured by photometric methods. Data were analyzed using SPSS version 16.0 (Chicago Illinois, (USA). Inferential statistic was done using Vilksonnon-parametric and Pearson's correlation test. P<0.05 were considered as signifi cant. Results: The mean serum Mg levels were 1.87 (0.32) mg/dl before and 1.55 (0.34) mg/dl after the surgeries (The normal range: = 1.7-2.5 mg/dl). Results illustrated a signifi cant hypomagnesemia after operations. Conclusion: Clinical impact of hypomagnesemia during surgeries needs to be studied further. Moreover, surgeons should be warned about the severity of probable electrolyte imbalances induced by perioperative events to decrease associated morbidities.

Effect of Low-Dose (Single-Dose) Magnesium Sulfate on Postoperative Analgesia in Hysterectomy Patients Receiving Balanced General Anesthesia

“…Another suggesting mechanism is the role of it on reduction of catecholamine release with sympathetic stimulation, thereby decreasing peripheral nociception or the stress response to the surgery. Data illustrate that the NMDA receptor antagonists “like Mg sulfate” have an effect on pain threshold and could prevent pain perception even with low doses (preventive doses) [ 1 , 9 , 15 , 18 , 20 , 21 , 24 – 27 ].…”

The Impact of Single Low Dose IV Magnesium Sulphate Adjuvant to Ultrasound Guided Transverses Abdominis Plain Block for Control of Postcesarean Pain

“…The mechanism of the analgesic effect of MgSO 4 is not clear but interference with calcium channels and N-methyl-D aspartate (NMDA) receptor seem to play an important role. The analgesic effect of NMDA-antagonists is made by inhibiting nociceptive central sensitization together with suggested reduction of catecholamine release with sympathetic stimulation, thereby decreasing peripheral nociception or the stress response to airway instrumentation and surgery [1] [6] [7] [8] [9] [10].…”

Randomized Controlled Clinical Study to Compare the Effect of Intravenous Magnesium Sulphate versus Diclofenac Sodium as Postoperative Analgesic after Abdominal Hysterectomy under General Anaesthesia

“…The mechanism of the analgesic effect of magnesium is not clear but interference with calcium channels and N-methyl-D-aspartate (NMDA) receptor seem to play an important role [5] .…”