1995
DOI: 10.1001/archotol.1995.01890040074012
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An Assessment of Cochlear Hair-Cell Loss in Insulin-Dependent Diabetes Mellitus Diabetic and Noise-Exposed Rats

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Cited by 38 publications
(38 citation statements)
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“…These changes strongly suggest that DM causes hearing loss. 27,[29][30][31][32] We found 18 cases (60 %) with altered vestibular tests. These findings are similar to published results 15,6,33,34 that have also shown altered vestibular tests.…”
Section: Discussionmentioning
confidence: 73%
See 1 more Smart Citation
“…These changes strongly suggest that DM causes hearing loss. 27,[29][30][31][32] We found 18 cases (60 %) with altered vestibular tests. These findings are similar to published results 15,6,33,34 that have also shown altered vestibular tests.…”
Section: Discussionmentioning
confidence: 73%
“…They raised the hypothesis that the effect of DM on vestibular function might be caused by complications such as diabetic neuropathy and angiopathy, which are absent in initial phases of the disease. Various authors 27,[29][30][31] have previously suggested that microangiopathy might be responsible for DM-associated altered inner ear function.…”
Section: Discussionmentioning
confidence: 99%
“…Earlier literature on rats and diabetic patients showed hearing disorder mainly because of edema in stria vascularis, decrease in number of outer hair cells and spiral ganglion. [23][24][25] Increased thresholds at high frequencies revealed that the cochlear regions may have been damaged due to angiopathy in the stria vascularis and spiral ligament, edema of stria vascularis which in turn leads to reduced intensity and frequency coding. 16,26,27 A study on auditory brainstem response in individuals with diabetes revealed poor response with prolonged latencies of wave III, V and also prolonged latencies of inter-peak III-V, I-III and I-V at 90 dB presentation level 28 which showed that there is a participation of the relay station of different order neuron in the central auditory nervous system.…”
Section: Discussionmentioning
confidence: 99%
“…Moreover, animal studies from several decades ago have experimented the impact of diabetes in inner ear. Rats with alloxan-or streptozocininduced diabetes were observed and the results led to thickening of basal membrane of vascular striae and loss of outer hair cells (Maia and de Campos, 2005;Costa, 1967;Smith et al, 1995;Raynor et al, 1995). In their literature review, David et al (2015) argued that these abnormalities are likely due to disruption of blood supply to the cochlea, reduction of blood flow in affected vessels, or vestibulocochlear nerve degeneration.…”
Section: Microangiopathymentioning
confidence: 99%