2012
DOI: 10.1111/gbb.12000
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An assessment of gene‐by‐environment interactions in developmental dyslexia‐related phenotypes

Abstract: While the genetic and environmental contributions to developmental dyslexia (DD) have been studied extensively, the effects of identified genetic risk susceptibility and of specified environmental hazardous factors have usually been investigated separately. We assessed potential gene-by-environment (GxE) interactions on DD-related reading, spelling and memory phenotypes. The presence of GxE effects were investigated for the DYX1C1, DCDC2, KIAA0319 and ROBO1 genes, and for seven specified environmental moderato… Show more

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Cited by 60 publications
(62 citation statements)
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“…In addition, studies from gene-by-environment interaction proved that the phenotype of dyslexia could be modulated by environmental factors (Hart, Soden, Johnson, Schatschneider, & Taylor, 2013;Mascheretti et al, 2013). Mascheretti et al (2013) concluded that a less supportive familial environment may increase the expression of detrimental dyslexiasusceptibility genes' alleles, which would remain undetected in a more supportive environment.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…In addition, studies from gene-by-environment interaction proved that the phenotype of dyslexia could be modulated by environmental factors (Hart, Soden, Johnson, Schatschneider, & Taylor, 2013;Mascheretti et al, 2013). Mascheretti et al (2013) concluded that a less supportive familial environment may increase the expression of detrimental dyslexiasusceptibility genes' alleles, which would remain undetected in a more supportive environment.…”
Section: Discussionmentioning
confidence: 99%
“…Mascheretti et al (2013) concluded that a less supportive familial environment may increase the expression of detrimental dyslexiasusceptibility genes' alleles, which would remain undetected in a more supportive environment. Similarly, Friend noticed that the heritability of word recognition deficits increased significantly with the increasing levels of parental education (Friend et al, 2008(Friend et al, , 2009.…”
Section: Discussionmentioning
confidence: 99%
“…Consistent with this possibility is the finding that higher-SES and lower-SES environments interact differently with genetic factors related to RD (Friend et al 2008;Mascheretti et al 2013). A large study of twins with reading difficulty revealed differences in the heritability of reading disability across SES, such that environmental factors accounted for more of the variance in reading deficits in children from lower-SES families than higher-SES families (Friend et al 2008;but see Kirkpatrick et al 2011 for conflicting findings).…”
Section: Relation Of Ses and Rd Severity To Intervention Response Andmentioning
confidence: 92%
“…Study on school-aged children from Avon Longitudinal Study of Parents and Children (ALSPAC) found that prenatal nicotine exposure was associated with poor performance in specific reading skill outcomes, especially in decoding single words21. Mascheretti et al 22 reported that maternal smoking during pregnancy interacted with dyslexia candidate gene DYX1C1 and affected dyslexia-related reading, spelling and memory phenotypes. Maternal hypertension diseases were found reduced the verbal ability, not non-verbal ability, in the 10 aged children from Western Australian Pregnancy Cohort (Raine) Study23.…”
mentioning
confidence: 99%