An assessment of metronidazole in the treatment of acute ulcerative pseudomembranous gingivitis (Vincent's disease)

Jp, Fletcher; Plant, Chris

doi:10.1016/0030-4220(66)90362-8

Cited by 8 publications

(4 citation statements)

References 6 publications

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“…The fact remains that AUG is an anaerobic infection and responds to metronidazole with or without local debridement (Shinn 1962, Shinn et al 1965, Duckworth et al 1966, Wade et al 1966, Fletcher & Plant 1968). The routine treatment of AUG consists of debridement, in the form of scaling, oral hygiene instruction, and surgical recontouring of the periodontium at a later date, should the tissues be permanently disfigured.…”

Section: Clinical Use Of Metronidazolementioning

confidence: 99%

Metronidazole: its use in clinical dentistry

Mitchell

1984

J Clinic Periodontology

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The increasing awareness of the role of obligate anaerobic bacteria in the aetiology of oral disease has led to an interest in their chemotherapeutic control. Many drugs are capable of eliminating anaerobes but in instances where these bacteria are acting as sole or major pathogens it is desirable to remove these specifically. The nitroimidazole group of drugs is specifically anti-anaerobic in nature and includes metronidazole, nimorazole and tinidazole. This paper reviews the literature on metronidazole. This drug is absorbed well from the gastrointestinal tract and can be detected at bactericidal levels in blood and saliva within 1 h of ingestion. The mode of action of metronidazole is unknown but thought to concern intracellular reduction of the molecule. The drug acts specifically against anaerobes and does not disturb the commensal aerobic flora; resistance very rarely develops. The dosage recommended for use in dentistry would appear to be very safe. Metronidazole has important interactions with alcohol, disulfiram and warfarin and there are contraindications to its use. Metronidazole has been proved to be efficacious in treating: acute ulcerative gingivitis, pericoronitis, certain periapical infections, some cases of osteomyelitis and infected socket. The drug may be of use in cases of chronic progressive periodontitis where anaerobes are implicated as pathogens.

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Section: Clinical Use Of Metronidazolementioning

confidence: 99%

Metronidazole: its use in clinical dentistry

Mitchell

1984

J Clinic Periodontology

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“…Although specific studies have not been reported, it is likely that lincomycin and clindamycin would also be useful. There is some recent evidence that the antitrichromonal drug metronidazole may also be effective.. 5,6 584 Antibiotics in Periodontics 585 Volume 42 Number 9 It is not particularly surprising that the topical use of vancomycin has been demonstrated to be effective against ANUG. 7,8 However, the fact that an antibiotic is applied locally rather than systemically does not negate the previously stated objections to routine antibiotic therapy in ANUG.…”

Section: Acute Necrotizing Ulcerative Gingivitismentioning

confidence: 99%

Antibiotics in the Practice of Periodontics

Holroyd

1971

Journal of Periodontology

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“…The patient had a “double cure” after being treated with MTZ for a week. Thereafter, MTZ began to be used to treat several anaerobic infections of the oral cavity, including periodontitis—a chronic inflammatory disease of infectious origin (Fletcher & Plant, 1966; Herrera et al., 2014; Loesche et al., 2002; Teughels et al., 2020). In periodontitis, specific bacterial species trigger/amplify host responses that culminate in the destruction of tooth‐supporting tissues.…”

Section: Introductionmentioning

confidence: 99%

Metronidazole may display anti‐inflammatory features in periodontitis treatment: A scoping review

Suárez,

Arce,

Gonçalves

et al. 2024

Molecular Oral Microbiology

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AimMetronidazole (MTZ) is an antimicrobial agent used to treat anaerobic infections. It has been hypothesized that MTZ may also have anti‐inflammatory properties, but the evidence is limited and has not been previously reviewed. Thus, this scoping review aimed to answer the following question: “What is the evidence supporting anti‐inflammatory properties of metronidazole that are not mediated by its antimicrobial effects?”MethodsA scoping review was conducted according to the PRISMA‐ScR statement. Five databases were searched up to January 2023 for studies evaluating the anti‐inflammatory properties of MTZ used as monotherapy for treating infectious and inflammatory diseases.ResultsA total of 719 records were identified, and 27 studies (21 in vivo and 6 in vitro) were included. The studies reported experimental evidence of MTZ anti‐inflammatory effects on (1) innate immunity (barrier permeability, leukocyte adhesion, immune cell populations), (2) acquired immunity (lymphocyte proliferation, T‐cell function, cytokine profile), and (3) wound healing/resolution of inflammation.ConclusionTaken together, this scoping review supported a potential anti‐inflammatory effect of MTZ in periodontitis treatment. We recommend that future clinical studies should be conducted to evaluate specific MTZ anti‐inflammatory pathways in the treatment of periodontitis.

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An assessment of metronidazole in the treatment of acute ulcerative pseudomembranous gingivitis (Vincent's disease)

Cited by 8 publications

References 6 publications

Metronidazole: its use in clinical dentistry

Metronidazole: its use in clinical dentistry

Antibiotics in the Practice of Periodontics

Metronidazole may display anti‐inflammatory features in periodontitis treatment: A scoping review

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