An association between IL-10 promoter polymorphisms and diabetic nephropathy: a meta-analysis of case-control studies

Naing, Cho; Htet, Norah Htet; Basavaraj, Arun Kumar; Nalliah, Sivalingam

doi:10.1007/s40200-018-0349-3

Cited by 17 publications

(15 citation statements)

References 35 publications

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“…In addition, there was no evidence of publication bias for IL-10 promoter variants were detected. Our meta-analysis is consistent with previous meta-analysis in which a trend for protective effect was documented for -1082 A>G and/or -819 C>T (10,21). Another meta-analysis demonstrated significantly increased risk of DN with -1082 A>G polymorphism (22).…”

Section: Discussionsupporting

confidence: 92%

Interleukin-10 gene promoter variants and susceptibility to diabetic nephropathy; a meta-analysis

et al. 2020

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Introduction: Diabetic nephropathy (DN) is a leading cause of chronic kidney disease (CKD) in diabetes patients. There is ample evidence that the inflammatory pathways are central to both diabetes and DN. Several studies that examined the link between the interleukin-10 (IL10) polymorphisms and DN risk yielded conflicting results. Objectives: The purpose of this meta-analysis is to evaluate the associations between IL10 promoter polymorphisms and DN risk. Methods: A bibliographic search was carried out on PubMed, Google scholar and Web of Science from the beginning until July 30, 2020. Association between IL10 promoter variants (-1082 A>G, -819 C>T and -592 C>A) and DN risk were assessed by considering diabetes without nephropathy (DWN) as well as healthy controls. Data were retrieved and the pooled odds ratio (OR) with 95% confidence interval (CI) was calculated. Results: For the IL10 -1082 A> G analysis, a total of 4 studies with DWN controls (682 cases and 529 controls) and 5 studies with healthy controls (1025 cases and 1625 controls) were considered. For the IL10 -819 C> T analysis, a total of three studies with DWN controls (9619 cases and 445 controls) and 5 studies with healthy controls (1005 cases and 1537 controls) were considered. For the IL10 -592 C> T analysis, a total of 5 studies with DWN controls (819 cases and 645 controls) and 5 studies with healthy controls (1005 cases and 1537 controls) were considered. In addition, there was no evidence of publication bias for IL10 promoter variants. No substantial association was observed between IL10 promoter variants and DN risk. Conclusion: Our study signifies that polymorphisms of IL10 -1082 A>G, -819 C>T and -592 C>A are not linked with DN risk.

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Section: Discussionsupporting

confidence: 92%

Interleukin-10 gene promoter variants and susceptibility to diabetic nephropathy; a meta-analysis

et al. 2020

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“…Due to its anti-inflammatory actions, it improves vascular and renal function in preclinical hypertension studies [ 64 ]. A recent meta-analysis on IL-10 gene polymorphisms suggests protective effects of some single nucleotide polymorphisms (SNPs) on the risk of developing diabetic nephropathy in type 2 DM [ 65 ].…”

Section: Cytokinesmentioning

confidence: 99%

Review on Inflammation Markers in Chronic Kidney Disease

et al. 2021

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Chronic kidney disease (CKD) is one of the major health problems of the modern age. It represents an important public health challenge with an ever-lasting rising prevalence, which reached almost 700 million by the year 2017. Therefore, it is very important to identify patients at risk for CKD development and discover risk factors that cause the progression of the disease. Several studies have tackled this conundrum in recent years, novel markers have been identified, and new insights into the pathogenesis of CKD have been gained. This review summarizes the evidence on markers of inflammation and their role in the development and progression of CKD. It will focus primarily on cytokines, chemokines, and cell adhesion molecules. Nevertheless, further large, multicenter studies are needed to establish the role of these markers and confirm possible treatment options in everyday clinical practice.

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“…Second, environmental factors might also affect relationships between TNF-α/IL-1/IL-6/IL-8/IL-18 polymorphisms and predisposition of DN/DR. However, the majority of authors only investigated genetic associations in their works, so genetic-environmental interactions could not be explored in our meta-analysis [63]. Third, we did not enroll gray literature for analyses because these literature studies are always incomplete, and it is hard to assess their methodology quality.…”

Section: Discussionmentioning

confidence: 99%

The Effects of Cytokine Polymorphisms on Predisposition to Microvascular Complications of Diabetes Mellitus: A Meta-Analysis

Feng

Liu

2021

Int Arch Allergy Immunol

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Background: It is plausible that gene polymorphisms in tumor necrosis factor-α (TNF-α), interleukin (IL)-1, IL-6, IL-8, and IL-18 may affect predisposition to microvascular complications of diabetes mellitus (DM), but the results of the so far published studies remain controversial. Objectives: We conducted this meta-analysis to clarify relationships between TNF-α/IL-1/IL-4/IL-8/IL-18 polymorphisms and predisposition to microvascular complications of DM by pooling the findings of eligible studies. Methods: A comprehensive search of PubMed, Embase, Web of Science, and CNKI was endorsed by us to identify already published studies. Forty-nine studies were found to be eligible for the meta-analyses. Results: The pooled meta-analyses results showed that genotypic frequencies of TNF-α −238 G/A, TNF-α −308 G/A, TNF-α −1,031 T/C, IL-1A −889 C/T, IL-1B −511 C/T, IL-6 −572 G/C, and IL-18 −137 G/C polymorphisms among patients with diabetic nephropathy (DN) and controls differed significantly. Moreover, genotypic frequencies of TNF-α −238 G/A and IL-8 −251 A/T polymorphisms among patients with diabetic retinopathy (DR) and controls also differed significantly. Conclusions: This meta-analysis suggested that TNF-α −238 G/A, TNF-α −308 G/A, TNF-α −1,031 T/C, IL-1A −889 C/T, IL-1B −511 C/T, IL-6 −572 G/C, and IL-18 −137 G/C polymorphisms may affect predisposition of DN. Moreover, TNF-α −238 G/A and IL-8 −251 A/T polymorphisms may affect predisposition of DR.

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An association between IL-10 promoter polymorphisms and diabetic nephropathy: a meta-analysis of case-control studies

Cited by 17 publications

References 35 publications

Interleukin-10 gene promoter variants and susceptibility to diabetic nephropathy; a meta-analysis

Interleukin-10 gene promoter variants and susceptibility to diabetic nephropathy; a meta-analysis

Review on Inflammation Markers in Chronic Kidney Disease

The Effects of Cytokine Polymorphisms on Predisposition to Microvascular Complications of Diabetes Mellitus: A Meta-Analysis

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