An association between resistant hypertension and the null GSTM1 genotype

Cruz-González, Ignacio; Corral, Esther; Sánchez-Ledesma, María; Sánchez‐Rodríguez, Ángel; Martín-Luengo, Cándido; González‐Sarmiento, Rogelio

doi:10.1038/jhh.2009.19

Cited by 15 publications

(13 citation statements)

References 14 publications

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“…Some studies estimate that other members of the GST enzyme family must have compensated for the absence of a functional enzyme in the double deletion subjects [33,34], which leads to the same level of activity of GST both in the null and active genotype. In addition to not con rming our initial hypothesis, our results may also not support the hypothesis that expression of the GSTM1 gene could protect against resistant hypertension [11].…”

Section: Discussioncontrasting

confidence: 95%

“…These results suggest that GST could affect the bioavailability of certain drugs which acts as GST enzyme substrate. To date, no study to our knowledge has evaluated the link between GST and antihypertensive responses, although Glutathione S-transferases Mu1 deletion has been associated with resistant hypertension [11]. In this study we hypothesized that the active variants of Glutathione S-transferases Mu1 (GSTM1) and theta 1 (GSTT1) which have normal detoxi cation activity could reduce the bioavailability of certain antihypertensive drugs and therefore affect the control of BP in hypertensive patients.…”

Section: Introductionmentioning

confidence: 99%

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Glutathione S-transferase M1 and T1 Genes Deletion Polymorphisms and Blood Pressure Control Among Treated Essential Hypertensive Patients in Burkina Faso.

SOMBIE

Tchélougou

Sorgho

et al. 2020

Preprint

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ObjectiveGlutathione S-transferases have been associated with experimental resistance to some drugs. The present study investigated the factors associated with blood pressure control in patients with essential hypertension, especially the role of GSTT1 and GSTM1 genes polymorphisms. This cross-sectional study in Burkina Faso consisted of 200 patients with essential hypertension and under treatment. ResultsThis cross-sectional study population consisted of 57.5 % (115/200) of patients with their hypertension under control. No statistically significant difference (p > 0.05) was found between controlled and uncontrolled (SBP and/or DBP) groups for anthropometric and biochemical parameters as well as for GSTT1 or GSTM1 gene polymorphisms. However, current alcohol consumption (OR = 3.04; CI = 1.88 - 6.13; p < 0.001), physical inactivity (OR = 3.07; CI = 1.71 - 5.49; p < 0.001), severity of hypertension (Grade III [OR = 3.79; CI = 2.00 - 7.17; p < 0.001]) and heart damage (OR = 3, 14; CI = 1.59 - 6.02; p < 0.001) were statistically more frequent in uncontrolled essential hypertension group than controlled group.

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Section: Discussioncontrasting

confidence: 95%

Section: Introductionmentioning

confidence: 99%

Glutathione S-transferase M1 and T1 Genes Deletion Polymorphisms and Blood Pressure Control Among Treated Essential Hypertensive Patients in Burkina Faso.

SOMBIE

Tchélougou

Sorgho

et al. 2020

Preprint

View full text Add to dashboard Cite

show abstract

“…Recent reviews targeting strategies to uncover the genetic background of complex traits (such as hypertension) have suggested that extreme phenotype samples (such as TRH) may be enriched for variants underlying the disease 26,27 . Several small candidate gene studies have reported associations with TRH that warrant follow‐up investigations 28–30 . For instance, one study reported the angiotensinogen M235T polymorphism was associated with increased risk for TRH, especially after age 50, highlighting a potential gene variant by age interaction 29 .…”

Section: Discussionmentioning

confidence: 99%

“…26,27 Several small candidate gene studies have reported associations with TRH that warrant follow-up investigations. [28][29][30] For instance, one study reported the angiotensinogen M235T polymorphism was associated with increased risk for TRH, especially after age 50, highlighting a potential gene variant by age interaction. 29 Replication of preliminary results from smaller studies should be carried out in larger cohorts.…”

Section: Discussionmentioning

confidence: 99%

Prevalence and Correlates of Low Medication Adherence in Apparent Treatment‐Resistant Hypertension

Irvin

Shimbo

Mann

et al. 2012

J of Clinical Hypertension

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Low medication adherence may explain part of the high prevalence of apparent treatment resistant hypertension (aTRH). We assessed medication adherence and aTRH among 4,026 participants taking ≥ 3 classes of antihypertensive medication in the population-based REGARDS Study using the 4-item Morisky Medication Adherence Scale (MMAS). Low adherence was defined as a MMAS score ≥ 2. Overall, 66% of participants taking ≥ 3 classes of antihypertensive medication had aTRH. Perfect adherence on the MMAS was reported by 67.8% and 70.9% of participants with and without aTRH, respectively. Low adherence was present among 8.1% of participants with aTRH and 5.0% of those without aTRH (p<0.001). Among those with aTRH, female gender, residence outside the US stroke belt or stroke buckle, physical inactivity, elevated depressive symptoms, and a history of coronary heart disease were associated with low adherence. In the current study, a small percentage of participants with aTRH had low adherence.

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“…Decrease GSTM1 expression may reduce antioxidant defenses, resulting low GSTM1 levels may lead to increased superoxide formation and reduced nitric oxide bioavailability [37]. Endothelial dysfunction is defined as the imbalance between the production and bioavailability of endothelium-derived relaxing factors (EDRFs) and endothelium derived contractile factors (EDCFs), associated with increased bioavailability of oxygen reactive species (ROS) and decreased antioxidant capacity characterized as oxidative stress [38].…”

Section: Discussionmentioning

confidence: 99%

Lymphocyte DNA damage and plasma antioxidant status in Korean subclinical hypertensive patients by glutathione S-transferase polymorphism

et al. 2017

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BACKGROUND/OBJECTIVESGlutathione S-transferase (GST) forms a multigene family of phase II detoxification enzymes which are involved in the detoxification of xenobiotics by conjugating substances with glutathione. The aim of this study is to assess the antioxidative status and the degree of DNA damage in the subclinical hypertensive patients in Korea using glutathione S-transferase polymorphisms.SUBJECTS/METHODSWe examined whether DNA damage and antioxidative status show a difference between GSTM1 or GSTT1 genotype in 227 newly diagnosed, untreated (systolic blood pressure (BP) ≥ 130 mmHg or diastolic BP ≥ 85 mmHg) subclinical hypertensive patients and 130 normotensive subjects (systolic BP < 120 mmHg and diastolic BP < 80 mmHg). From the blood of the subjects, the degree of the DNA damage in lymphocyte, the activities of erythrocyte superoxide dismutase, the catalase, and the glutathione peroxidase, the level of glutathione, plasma total radical-trapping antioxidant potential (TRAP), anti-oxidative vitamins, as well as plasma lipid profiles and conjugated diene (CD) were analyzed.RESULTSOf the 227 subjects studied, 68.3% were GSTM1 null genotype and 66.5% were GSTT1 null genotype. GSTM1 null genotype had an increased risk of hypertension (OR: 2.104, CI: 1.38-3.35), but no significant association in GSTT1 null genotype (OR 0.982, CI: 0.62-1.55). No difference in erythrocyte activities of superoxide dismutase, catalase, or glutathione peroxidase, and plasma TRAP, CD, lipid profiles, and GSH levels were observed between GSTM1 or GSTT1 genotype. Plasma levels of α-tocopherol increased significantly in GSTT1 wild genotype (P < 0.05); however, plasma level of β-carotene increased significantly in GSTT1 null genotype (P < 0.01). DNA damage assessed by the Comet assay was significantly higher in GSTM1 null genotype than wild genotype (P < 0.05).CONCLUSIONSThese results confirm the association between GSTM1 null genotype and risk of hypertension as they suggest that GSTM1 null genotype leads to an increased oxidative stress compared with wild genotype.

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An association between resistant hypertension and the null GSTM1 genotype

Cited by 15 publications

References 14 publications

Glutathione S-transferase M1 and T1 Genes Deletion Polymorphisms and Blood Pressure Control Among Treated Essential Hypertensive Patients in Burkina Faso.

Glutathione S-transferase M1 and T1 Genes Deletion Polymorphisms and Blood Pressure Control Among Treated Essential Hypertensive Patients in Burkina Faso.

Prevalence and Correlates of Low Medication Adherence in Apparent Treatment‐Resistant Hypertension

Lymphocyte DNA damage and plasma antioxidant status in Korean subclinical hypertensive patients by glutathione S-transferase polymorphism

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