Prevalence and Correlates of Low Medication Adherence in Apparent Treatment‐Resistant Hypertension

Irvin, Marguerite R.; Shimbo, Daichi; Mann, David; Reynolds, Kristi; Krousel‐Wood, Marie; Limdi, Nita A.; Lackland, Daniel T.; Calhoun, David A.; Oparil, Suzanne; Muntner, Paul

doi:10.1111/j.1751-7176.2012.00690.x

Cited by 71 publications

(63 citation statements)

References 40 publications

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“…Considering the types of the most prescribed medications in this study, we observe that the rate of adherence found is in agreement with the literature, in which adherence to diabetes and high blood pressure medication ranges from 36% to 66% (22)(23) .…”

Section: As This Study Shows An Association Betweensupporting

confidence: 79%

Common Mental Disorders: socio-demographic and pharmacotherapy profile

Gomes

Miguel

Miasso

2013

Rev. Latino-Am. Enfermagem

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OBJECTIVE: this study reports an association between Common Mental Disorders and the socio-demographic and pharmacotherapy profiles of 106 patients cared for by a Primary Health Care unit in the interior of São Paulo, Brazil. METHOD: this is a cross-sectional descriptive exploratory study with a quantitative approach. Structured interviews and validated instruments were used to collect data. The Statistical Package for Social Science was used for analysis. RESULTS: The prevalence of Common Mental Disorders was 50%. An association was found between Common Mental Disorders and the variables occupation, family income, number of prescribed medications and number of pills taken a day. Greater therapy non-adherence was observed among those who tested positive for Common Mental Disorders. CONCLUSION: this study's results show the importance of health professionals working in PHC to be able to detect needs of a psychological nature among their patients and to support the implementation of actions to prevent the worsening of Common Mental Disorders.

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Section: As This Study Shows An Association Betweensupporting

confidence: 79%

Common Mental Disorders: socio-demographic and pharmacotherapy profile

Gomes

Miguel

Miasso

2013

Rev. Latino-Am. Enfermagem

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“…A recent large population-based study in the United States, the Reasons for Geographic and Racial Differences in Stroke (REGARDS) study, also reported very low prevalence of non-adherence of only 8%, using the four-item MMAS. 23 We also identified a higher proportion of females in the non-adherent group, which was consistent with findings from the REGARDS study 23 and one previous study in BMI, body mass index; BP, blood pressure; bpm, beats per minute; CKD, chronic kidney disease; DBP, diastolic blood pressure; ED, erectile dysfunction; eGFR, estimated glomular filtration rate; OSA, obstructive sleep apnea; SBP, systolic blood pressure; TDM, therapeutic drug monitoring.…”

Section: Discussionmentioning

confidence: 99%

Comparison of Morisky Medication Adherence Scale with therapeutic drug monitoring in apparent treatment–resistant hypertension

Pandey

Raza

Velasco

et al. 2015

Journal of the American Society of Hypertension

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The Morisky Medication Adherence Scale (MMAS-8) is a questionnaire developed for screening of non-adherence in patients with several chronic conditions, including uncomplicated hypertension. However, its accuracy in predicting nonadherence in patients with apparent treatment-resistant hypertension (a-TRH) is not known. Accordingly, we performed a retrospective study in 47 patients with a-TRH who had completed the eight-item MMAS during the initial clinic visit. Non-adherence was defined as presence of undetected serum levels of at least one prescribed antihypertensive drug by therapeutic drug monitoring. We found that 26% of patients were considered to have low adherence score (<6), while the actual prevalence of non-adherence was 51% by therapeutic drug monitoring. Sensitivity of the MMAS-8 was 26% (95% confidence interval, 10.3%-48.4%) with specificity of 75% (95% confidence interval, 53.3%-90.2%). By multivariate analysis, the MMAS-8 score was not an independent predictor of non-adherence, while certain clinical parameters such as heart rate were found to be independent predictors of non-adherence. Our study suggested limited accuracy of the MMAS-8 in detecting medication non-adherence in a-TRH. J Am Soc Hypertens 2015;9(6):420-426.

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“…However, previous large studies using patient self-report or medication fill data have demonstrated that adherence is not appreciably different (and perhaps even greater) among patients with RH versus non-RH. 39,40 Finally, this is a retrospective analysis of three cohorts of women with varying underlying CVD and must be taken with a degree of caution. Although our results in women are consistent with studies in other populations, we cannot exclude the possibility that unmeasured confounders impacted our results.…”

Section: Study Limitationsmentioning

confidence: 99%

Mortality Risk Associated With Resistant Hypertension Among Women: Analysis from Three Prospective Cohorts Encompassing the Spectrum of Women's Heart Disease

SmithSteven

HuoTianyao

GongYan

et al. 2016

Journal of Women's Health

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Background: Women are at greater risk of developing resistant hypertension (RH) than men, yet scarce data exist on RH-associated outcomes in women. We aimed to determine all-cause mortality risk associated with apparent RH (aRH) among women across the spectrum of underlying coronary disease. Materials and Methods: We analyzed data from St. James Women Take Heart (WTH; women without coronary disease at baseline), Women's Ischemia Syndrome Evaluation (women with signs/symptoms of ischemia at baseline), and the INternational VErapamil-Trandolapril STudy (INVEST; women with coronary artery disease and hypertension at baseline), totaling 15,108 adult women with no hypertension, non-RH (blood pressure [BP] ‡140/90 mmHg on £2 drugs or BP <140/90 mmHg on 1-3 drugs), or aRH (BP ‡140/90 mmHg on ‡3 drugs or anyone on ‡4 drugs) at baseline. The primary outcome was all-cause mortality.Results: Prevalence of aRH ranged from 0.4% (WTH) to 10.6% (INVEST). Women with aRH, compared to those without, were older, more often black, and more likely to be obese or diabetic. Pooling all cohorts, risk for all-cause death was greater in women with aRH than in women with non-RH (adjusted HR 1.40; 95% CI 1.27-1.55) and women without hypertension (adjusted HR 2.34; 95% CI 1.76-3.11) over a median follow-up of 14.3 years. Conclusions: aRH prevalence in women varies according to underlying coronary disease, and aRH is associated with a substantial, early, and sustained increased risk of all-cause death. Additional research into early recognition and prevention strategies for RH are needed, especially in black and older women, and those with known cardiovascular risk factors.

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Prevalence and Correlates of Low Medication Adherence in Apparent Treatment‐Resistant Hypertension

Cited by 71 publications

References 40 publications

Common Mental Disorders: socio-demographic and pharmacotherapy profile

Common Mental Disorders: socio-demographic and pharmacotherapy profile

Comparison of Morisky Medication Adherence Scale with therapeutic drug monitoring in apparent treatment–resistant hypertension

Mortality Risk Associated With Resistant Hypertension Among Women: Analysis from Three Prospective Cohorts Encompassing the Spectrum of Women's Heart Disease

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