An association between urinary cadmium and urinary stone disease in persons living in cadmium-contaminated villages in northwestern Thailand: A population study

Swaddiwudhipong, Witaya; Mahasakpan, Pranee; Limpatanachote, Pisit; Krintratun, Somyot

doi:10.1016/j.envres.2011.01.007

Cited by 28 publications

(13 citation statements)

References 26 publications

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“…Only in women, increased urinary VitDBP was significantly associated with serum OC but association was not significant after adjusting serum Crea, indicating urinary VitDBP associated with increased urinary excretion by renal dysfunction. In Mae Sot residents, renal dysfunction, indicated by increased serum Crea, associated with Cd exposure was reported [9]. It was suggested that cadmium-induced renal dysfunction may alter the formation of the active form of vitamin D, 1,25-dihydroxy vitamin D, which occurs in the kidney.…”

Section: Discussionmentioning

confidence: 99%

“…Mae Sot people who live in the contaminated area have reported renal tubular dysfunction indicated by α1-, β2-microglobulin (MG), and N-acetyl-β-D-glucosamidinase (NAG) associated with urinary Cd [8]. Swaddiwudhipong et al [9] reported that increased serum creatinine (Crea) and decreased glomerular filtration rate was associated with increased urinary Cd in inhabitants in the same contaminated area in Mae Sot with urinary Cd ≥ 5 μg/g Crea. In our own previous research, we found an imbalance in Ca reabsorption because of remarkable renal tubular dysfunction that leads to increased bone resorption markers in residents in Mae Sot aged ≥50 years old, particularly female residents including premenopausal women [10].…”

Section: Introductionmentioning

confidence: 99%

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Gender-Specific Impact of Cadmium Exposure on Bone Metabolism in Older People Living in a Cadmium-Polluted Area in Thailand

Nishijo

Nambunmee

Suvagandha

et al. 2017

IJERPH

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To elucidate the influence of cadmium exposure on bone metabolism, associations between urinary/blood cadmium and bone resorption/formation markers were investigated in older cadmium exposed men and women. Increased urinary cross-linked N-telopeptide of type I collagen (NTx), a bone resorption marker, was found to be associated with increased levels of parathyroid hormone, fractional excretion of calcium, and urinary/blood cadmium after adjusting for confounding factors in men. In women, urinary NTx was significantly associated with only urinary cadmium and a strong relationship with increased fractional excretion of calcium. Risk for bone metabolic disorders, indicated by high urinary NTx, significantly increased in men with blood cadmium ≥ 10 μg/L or urinary cadmium ≥ 10 μg/g creatinine. Increased osteocalcin level was significantly associated with increased blood cadmium in men. In conclusion, cadmium exposure appeared to have an influence on bone remodeling both bone resorption and formation in this population of older Thai men, and blood cadmium was more closely associated with bone metabolism than urinary cadmium.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Gender-Specific Impact of Cadmium Exposure on Bone Metabolism in Older People Living in a Cadmium-Polluted Area in Thailand

Nishijo

Nambunmee

Suvagandha

et al. 2017

IJERPH

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“…Our results of Cd concentrations in urine and blood showed that cigarette smoke was one of the major Cd exposure routes for smoker that compared with nonsmoker, although present study did not take into account Cd contents in different brands of cigarette, the intensity of the habit, and its duration. Strong evidence suggested that the effects of Cd may be different in male and female [51][52][53]. At similar exposure levels, female had higher blood and urinary Cd concentrations than male.…”

Section: Daily Intake Via Seafood and Inhalationmentioning

confidence: 94%

Assessing human exposure risk to cadmium through inhalation and seafood consumption

Chen

Liao

2012

Journal of Hazardous Materials

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“…Furthermore, the urinary excretion route of Cd is the same as with other urinary substances including renal effect markers, and there is some concern about the effects of other substances in urine on the relationship between urinary Cd and renal dysfunction. Particularly, targeted Thai subjects in the present study showed a high prevalence of urinary tract stones [23], and significant increase in urinary β2-MG related increased urinary calcium (Ca)/citrate, a stone-forming risk factor correlated with urinary Cd [24]. …”

Section: Introductionmentioning

confidence: 99%

Risk assessment for Thai population: benchmark dose of urinary and blood cadmium levels for renal effects by hybrid approach of inhabitants living in polluted and non-polluted areas in Thailand

et al. 2014

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BackgroundThe aim of the present study was to estimate the benchmark doses (BMD) for renal effects for health risk assessment of residents living in Cd-polluted and non-polluted areas in a Thai population.MethodsThe study participants consisted of inhabitants aged 40 years or older who lived in a non-polluted area (40 men and 41 women) and in the environmentally polluted Mae Sot District (230 men and 370 women) located in northwestern Thailand. We measured urinary and blood cadmium (Cd) as markers of long-term exposure and urinary β2-microglobulin (β2-MG) and N-acetyl-β-D-glucosaminidase (NAG) as renal tubular effect markers. An updated hybrid approach was applied to estimate the benchmark doses (BMD) and their 95% lower confidence limits (BMDL) of urinary and blood Cd for Cd-induced renal effects in these subjects. BMD and BMDL corresponding to an additional risk (BMR) of 5% were calculated with the background risk at zero exposure set to 5% after adjusting for age and smoking status.ResultsThe estimated BMDLs of urinary Cd for renal effect markers were 6.9 for urinary β2-MG and 4.4 for NAG in men and 8.1 for β2-MG and 6.1 for NAG μg/g creatinine (Creat) in women. These BMDLs of urinary Cd (μg/g Creat) for NAG were less than the geometric mean urinary Cd in the polluted area (6.5 in men and 7.1 in women). The estimated BMDLs of blood Cd (μg/L) were 6.2 for urinary β2-MG and 5.0 for NAG in men and 5.9 for β2-MG and 5.8 for NAG in women. The calculated BMDLs were similar or less compared with the geometric mean blood Cd (μg/L) in the polluted Thai area (6.9 in men and 5.2 in women).ConclusionThe BMDLs of urinary and blood Cd for renal effects were estimated to be 4.4 - 8.1 μg/g Creat and 4.4 - 6.2 μg/L in the Thai population aged ≥ 40 years old, suggesting that more than 40% of the residents were at risk of adverse renal effects induced by Cd exposure in Thailand.

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An association between urinary cadmium and urinary stone disease in persons living in cadmium-contaminated villages in northwestern Thailand: A population study

Cited by 28 publications

References 26 publications

Gender-Specific Impact of Cadmium Exposure on Bone Metabolism in Older People Living in a Cadmium-Polluted Area in Thailand

Gender-Specific Impact of Cadmium Exposure on Bone Metabolism in Older People Living in a Cadmium-Polluted Area in Thailand

Assessing human exposure risk to cadmium through inhalation and seafood consumption

Risk assessment for Thai population: benchmark dose of urinary and blood cadmium levels for renal effects by hybrid approach of inhabitants living in polluted and non-polluted areas in Thailand

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