An association study of NRAMP1, VDR, MBL and their interaction with the susceptibility to tuberculosis in a Chinese population

Abstract

Our study suggests that genotypes of many polymorphic genes are associated with TB, it is necessary to further explore the mechanism of genotypes and gene-gene interaction in susceptibility to tuberculosis.

Association of Mannose-binding Lectin Polymorphisms with Tuberculosis Susceptibility among Chinese

“…We noted that Wu et al . have reported that LYPB haplotype was associated with TB in southern Chinese23. However, frequencies of MBL2 haplotypes in Wu’s study were remarkably different from those in Chinese subjects observed in other studies.…”

“…These studies have small sample size, usually involving about 200 or less PTB patients of Chinese origin1920212223, which might lead to artificial associations. In addition, the four functional SNPs in the MBL2 gene is in linkage disequilibrium (LD) and more appropriate to be investigated together (in both haplotype and haplotype pairs).…”

“…Other investigators instead claim that protection against the disease is associated with high levels of MBL (controlled by the wild MBL2 alleles)15161718. In the Chinese Han population, no convincing evidence of association between MBL2 sequence variants and TB was observed1920212223. For example, in a meta-analysis totally including 880 TB patients and 959 controls of Chinese origin, Shi J and colleagues reported that variants at A/B were associated with increased susceptibility to TB20.…”

“…Additionally, Chen M and colleagues found that variants in Y/X was associated with increased susceptibility to TB among Chinese2122. However, most recently Wu L reported that variants in H/L, but not Y/X, P/Q or A/B, were associated with decreased susceptibility to TB among Chinese23. Conflicting results are not unexpected in association studies for several reasons, including small sample size, marginal statistical significance, detection of genotypes, or ethnic heterogeneity.…”

A Meta-analysis of MBL2 Polymorphisms and Tuberculosis Risk

“…In addition to the online database search, the references given in the screened articles were also reviewed for other potential studies. Lastly, after cautious screening and following the pre-set inclusion and exclusion criteria for the selection of the studies, a total of 22 research publications11121314151617181920212223242526272829303132, showing case-control studies comprising of a total of 7095 confirmed TB patients and 7662 control subjects were included in this pooled analysis (Fig. 1 PRISMA Flow-diagram).…”