An Asymmetric Microfluidic/Chitosan Device for Sustained Drug Release in Guided Bone Regeneration Applications

Shi, Xin; Ma, Beibei; Chen, Hongyu; Tan, Wei; Ma, Shiqing; Zhu, Guorui

doi:10.3390/bios12100847

Cited by 3 publications

(3 citation statements)

References 39 publications

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“…The avail of chitosan nanoparticles as nanocarriers can provide additional antimicrobial benefits. 189 5.5. Iron Oxide Nanoparticles.…”

Section: Polymeric Nanoparticles (Nps)mentioning

confidence: 99%

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Attributes of Nanomaterials and Nanotopographies for Improved Bone Tissue Engineering and Regeneration

Karmakar,

Dey,

Alam

et al. 2023

ACS Appl. Bio Mater.

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Bone tissue engineering (BTE) is a multidisciplinary area that can solve the limitation of conventional grafting methods by developing viable and biocompatible bone replacements. The three essential components of BTE, i.e., Scaffold material and Cells and Growth factors altogether, facilitate support and guide for bone formation, differentiation of the bone tissues, and enhancement in the cellular activities and bone regeneration. However, there is a scarcity of the appropriate materials that can match the mechanical property as well as functional similarity to native tissue, considering the bone as hard tissue. In such scenarios, nanotechnology can be leveraged upon to achieve the desired aspects of BTE, and that is the key point of this review article. This review article examines the significant areas of nanotechnology research that have an impact on regeneration of bone: (a) scaffold with nanomaterials helps to enhance physicochemical interactions, biocompatibility, mechanical stability, and attachment; (b) nanoparticle-based approaches for delivering bioactive chemicals, growth factors, and genetic material. The article begins with the introduction of components and healing mechanisms of bone and the factors associated with them. The focus of this article is on the various nanotopographies that are now being used in scaffold formation, by describing how they are made, and how these nanotopographies affect the immune system and potential underlying mechanisms. The advantages of 4D bioprinting in BTE by using nanoink have also been mentioned. Additionally, we have investigated the importance of an in silico approach for finding the interaction between drugs and their related receptors, which can help to formulate suitable systems for delivery. This review emphasizes the role of nanoscale approach and how it helps to increase the efficacy of parameters of scaffold as well as drug delivery system for tissue engineering and bone regeneration.

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“…The avail of chitosan nanoparticles as nanocarriers can provide additional antimicrobial benefits. 189 5.5. Iron Oxide Nanoparticles.…”

Section: Polymeric Nanoparticles (Nps)mentioning

confidence: 99%

“…Chitosan has inherent antibacterial properties, that can help prevent infections around bone regeneration. The avail of chitosan nanoparticles as nanocarriers can provide additional antimicrobial benefits …”

Section: Nanocarriers For Drug Delivery In Bone Regenerationmentioning

confidence: 99%

Attributes of Nanomaterials and Nanotopographies for Improved Bone Tissue Engineering and Regeneration

Karmakar,

Dey,

Alam

et al. 2023

ACS Appl. Bio Mater.

View full text Add to dashboard Cite

show abstract

“…Pathogen infection is the major challenge affecting guided bone regeneration. Shi et al [21] developed an asymmetric microfluidic/chitosan device for releasing drugs so as to prevent infections and guide bone regeneration. Their device achieved the controllable drug release (the deviation of the minocycline release was only 12.7% over 5 days).…”

mentioning

confidence: 99%