An atlas of thyroid hormone receptors target genes in mouse tissues

Abstract

We gathered in a single database available RNA-seq and ChIP-seq data to better characterize the target genes of the thyroid hormone receptors in several cell types. This database can serve as a resource to analyze the mode of action of the hormone. Also, it is an easy-handling convenient tool to obtain information on specific genes in regards to T3 regulation, or extract larger list of genes of interest based on the users criteria. Overall, this atlas is a unique compilation of recent sequencing data focusing on thyroid hormones, their receptors, mode of action, targets and roles which may profit researchers within the field. A preliminary analysis indicates extensive variations in the repertoire of target genes which transcription is upregulated by chromatin-bound nuclear receptor. Although it has a major influence, chromatin accessibility is not the only parameter that determines the cellular selectivity of hormonal response.

Thyroid hormone as a temporal switch in mouse development

“…Overall, most if not all mammalian cells have the ability to respond to T3 throughout development. However, in contrast to the amphibian genes, the response of the mouse Thrb gene expression to T3 is modest, and restricted to a few cell types, while Thra gene tends to be downregulated (14). Therefore the T3 response in mammals is unlikely to be amplified by a positive feedback loop resulting in receptors accumulation.…”