1992
DOI: 10.1177/030098589202900211
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An Atypical Neuroendocrine Tumor in the Lung of a Beagle Dog

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Cited by 25 publications
(18 citation statements)
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“…15 In human medicine, NE carcinomas have been found in a wide range of organs, with the gastrointestinal 2 and pulmonary tracts 12 being the most common sites. In domestic animals, NE carcinomas have been occasionally reported in the intestines, 6 liver, 18 lungs, 11 esophagus, 17 skin, 19 and nasal cavity, 16 specifically from dogs and cats. Neuroendocrine carcinomas typically have the histopathologic pattern of sheets and nests of small-to mediumsized cells separated by a delicate fibrovascular stroma, which are characteristics that help the pathologist recognize these neoplasms as being of endocrine origin.…”
mentioning
confidence: 99%
“…15 In human medicine, NE carcinomas have been found in a wide range of organs, with the gastrointestinal 2 and pulmonary tracts 12 being the most common sites. In domestic animals, NE carcinomas have been occasionally reported in the intestines, 6 liver, 18 lungs, 11 esophagus, 17 skin, 19 and nasal cavity, 16 specifically from dogs and cats. Neuroendocrine carcinomas typically have the histopathologic pattern of sheets and nests of small-to mediumsized cells separated by a delicate fibrovascular stroma, which are characteristics that help the pathologist recognize these neoplasms as being of endocrine origin.…”
mentioning
confidence: 99%
“…In people, the identified sites of the primary tumors are the larynx, lung, 2,3 mediastinum, urinary bladder, 26 uterus, or uterine cervix. 6,8,9 Although a major limitation in the present case is the absence of a full necropsy evaluation, the presence of a single large tumor in the nose and multiple smaller, uniformly sized tumors in the dermis is highly suggestive of a primary nasal tumor with cutaneous metastases.…”
Section: Discussionmentioning
confidence: 85%
“…46 In the dog, an NSEnegative NE tumor has been described;s0 however, recently foci of NSE-immunoreactive cells in an atypical NE lung tumor also have been reported. 24 The carcinomas show histologic characteristics of NE turn or^.^ Only small clusters of cells immunoreactive for NSE were seen in these tumors. Although NSE antibodies also react with myoepithelial cells, a myoepithelial origin of these NSE-immunoreactive tumor cells is unlikely because these cells were not labeled with the a-smooth muscle actin MoAb.…”
Section: Discussionmentioning
confidence: 90%