2022
DOI: 10.1016/j.actbio.2022.05.034
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An auto-photoacoustic melanin-based drug delivery nano-platform for self-monitoring of acute kidney injury therapy via a triple-collaborative strategy

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Cited by 27 publications
(17 citation statements)
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“…Zhao et al used anti-GPR97-conjugated melanin nanoparticles as a carrier to load PJ34 and obtained a targeted nano-drug sustained-release platform (GMP nanoparticles) with PA imaging ability and triple therapeutic effects of anti-oxidation, anti-apoptosis, and anti-inflammation. 120 Since the GRP97 protein was significantly overexpressed on the renal tubular epithelial membrane during AKI, PA imaging confirmed that anti-GPR97 enhanced the renal targeting of GMP. GMP nanoparticles have good dispersibility, solubility, and biocompatibility; have anti-inflammatory and anti-apoptotic properties; and can scavenge various toxic ROS and effectively treat rhabdomyolysis-induced AKI.…”
Section: Application Of Antioxidant Enzymes In Akimentioning
confidence: 91%
“…Zhao et al used anti-GPR97-conjugated melanin nanoparticles as a carrier to load PJ34 and obtained a targeted nano-drug sustained-release platform (GMP nanoparticles) with PA imaging ability and triple therapeutic effects of anti-oxidation, anti-apoptosis, and anti-inflammation. 120 Since the GRP97 protein was significantly overexpressed on the renal tubular epithelial membrane during AKI, PA imaging confirmed that anti-GPR97 enhanced the renal targeting of GMP. GMP nanoparticles have good dispersibility, solubility, and biocompatibility; have anti-inflammatory and anti-apoptotic properties; and can scavenge various toxic ROS and effectively treat rhabdomyolysis-induced AKI.…”
Section: Application Of Antioxidant Enzymes In Akimentioning
confidence: 91%
“…Gold nanoclusters capped with NAC demonstrated improved antioxidative and anti-inflammatory effects compared with free NAC, achieving AKI reduction and reduced rodent mortality [19 â–Ș ]. Several other substances that were traditionally known to act as antioxidants have been loaded into nanoparticles targeted to RTEC, successfully reducing oxidative stress in the injured kidney and mitigating kidney dysfunction [20 â–Ș –26 â–Ș ]. A promising strategy has been to co-load within nanocarriers both ROS scavengers along with drugs used to treat other damage mechanisms to further reduce inflammation [27 â–Șâ–Ș ] or intracellular calcium, which is believed itself to trigger multiple damage mechanisms [28 â–Șâ–Ș ].…”
Section: Acute Kidney Injurymentioning
confidence: 99%
“…Excess ROS causes mitochondrial dysfunction and triggers apoptosis through excessive activation of PARP-1. RTEC targeted nanocarriers loaded with an inhibitor of PARP-1-ameliorated AKI by reducing apoptosis [26 â–Ș ].…”
Section: Acute Kidney Injurymentioning
confidence: 99%
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“…Prof. Quli Fan’s team developed a multifunctional nanoplatform based on ultrasmall water-soluble MNPs for trimodal imaging of PA, positron emission tomography, and MRI . Based on these research studies, our research group has synthesized a series of novel MNPs with safe, nontoxic, stable performance and uniform dispersion using human endogenous melanin as the raw material, applied them to a variety of disease models including acute kidney injury, in vivo stem cells, and tumors, − and successfully constructed an integrated nanoplatform for diagnosis and treatment guided by multimodal imaging. The multifunctional MNP utilized its small-sized feature to accumulate efficiently at the kidney through the filtration system of the glomerulus, realizing the passive targeting of melanin to the kidney.…”
Section: Introductionmentioning
confidence: 99%