An autologous protein gel for soft tissue augmentation: in vitro characterization and clinical evaluation

Fedyakova, Elena; Pino, Ander; Kogan, Lidiya; Eganova, Charusa; Troya, María; Anitua, Eduardo

doi:10.1111/jocd.12771

Cited by 17 publications

(23 citation statements)

References 51 publications

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“…Once injected, PRGF‐gel presents an hyperechogenic nodule pattern as its echographic hallmark. Ultrasound examinations performed in other studies revealed an augmentation of the dermo‐epidermal echodensity and an overall dermal thickness increase indicating newly synthesized components of the intercellular matrix and collagen fiber disposition . Post‐treatment results showed an increased echointensity of cutaneous connective tissue along with a decrease in the total hypoechoic areas .…”

Section: Discussionmentioning

confidence: 74%

“…Ultrasound examinations performed in other studies revealed an augmentation of the dermo‐epidermal echodensity and an overall dermal thickness increase indicating newly synthesized components of the intercellular matrix and collagen fiber disposition . Post‐treatment results showed an increased echointensity of cutaneous connective tissue along with a decrease in the total hypoechoic areas . In fact, some authors have described a reduction of the subepidermal low echogenic band (SLEB) after PRGF treatment, suggesting the potential of this technology for activating the cell turnover that might improve the tone and elasticity of skin thereby counterbalancing chronological aging mechanisms which slow metabolic activity and render skin atrophy .…”

Section: Discussionmentioning

confidence: 93%

“…Following specific fractioning, platelet activation and gelation protocols a three‐dimensional biomaterial that overcomes the limitations associated with the fibrin retraction process can be obtained. This 100% autologous formulation is able to release a wide range of bioactive proteins, offers desirable mechanical properties for cell ingrowth, and provides long‐term shape and volume reposition . Figure illustrates the differences between liquid PRGF, low‐viscosity PRGF‐gel and high‐viscosity PRGF‐gel in terms of regenerative potential, duration period, lifting capability, and ease of preparation.…”

Section: Introductionmentioning

confidence: 99%

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Plasma rich in growth factor gel as an autologous filler for facial volume restoration

Godfrey¹,

Martínez‐Escribano

Roó

et al. 2020

J of Cosmetic Dermatology

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Background Skin aging is characterized by moderate to severe wrinkles, laxity, roughness, and volume loss as a result of cutaneous atrophy and connective tissue degradation. Plasma rich in growth factor gel (PRGF‐gel) is a novel formulation obtained from the patient's own blood that has demonstrated optimal biomechanical and bioactive properties for soft tissue restoration. Objectives Following a retrospective design, the clinical safety and efficacy of PRGF‐gel for facial volume restoration and skin rejuvenation were evaluated. Methods Twenty women clinically diagnosed for aged skin symptoms were treated with PRGF‐gel. Participants received an individualized regimen depending on their therapeutic needs. At the end of the follow‐up periods, clinical performance analysis was evaluated by standardized macrophotographs along with clinical and patient surveys based on Likert's scales. Results Based on their initial expectations, patients referred to be highly satisfied after PRGF‐gel treatment in terms of fine line amelioration, wrinkle reduction, and sagging improvement (overall satisfaction of 8/10). Pre/post‐photograph clinical evaluation showed an improvement of 2.5/3 and patients presented a noticeable face rejuvenation due to the soft tissue augmentation effect which was translated into surface texture softening and tone recovery. Conclusions Although additional randomized clinical trials should be carried out, this study provides preliminary data supporting the use of PRGF‐gel for facial volume restoration.

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Section: Discussionmentioning

confidence: 74%

Section: Discussionmentioning

confidence: 93%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Plasma rich in growth factor gel as an autologous filler for facial volume restoration

Godfrey¹,

Martínez‐Escribano

Roó

et al. 2020

J of Cosmetic Dermatology

Self Cite

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“…This formulation provides a greater volume stability and long‐term shape maintenance that offers optimal mechanical stability for cutaneous defect viscosupplementation 12 . Recent clinical findings suggest that Endoret‐Gel acts as a volume enhancer biomaterial that reduces wrinkles and static lines along with a marked lifting effect that ultimately balances the cutaneous profile 13 …”

Section: Introductionmentioning

confidence: 99%

Combined therapy with Endoret‐Gel and plasma rich in growth factors vs Endoret‐Gel alone in the management of facial rejuvenation: A comparative study

Navarro¹,

Pino

Martínez‐Andrés³

et al. 2020

J of Cosmetic Dermatology

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Background Skin suffers progressive decrement. An endogenous regenerative technology has been developed that has the versatility to provide an autologous injectable gel (Endoret‐Gel) or a liquid plasma rich in growth factors (PRGF) based on the patient´s own platelet‐rich plasma. Aims To compare the efficacy of the combined therapy with Endoret‐Gel and PRGF versus Endoret‐Gel alone in the management of facial rejuvenation. Methods Twenty clinically diagnosed patients with aged skin received either Endoret‐Gel monotherapy or Endoret‐Gel + PRGF combined therapy. Patients underwent three sessions at one‐month intervals and were clinically assessed for six months. Corneometry, sebumetry, and high‐resolution topographic analysis were carried out. Patient self‐assessment questionnaires and clinical improvement scores were also performed. Results The combined therapy showed to promote a higher hydration index. These results were also significant for spot improvement at three months, while conversely, monotherapy with Endoret‐Gel demonstrated higher UV spot improvement. A significant decrease of sebum production and wrinkle development was observed for both treatment groups. Red areas also improved in a similar way at the end of the follow‐up period. After Endoret‐Gel or Endoret‐Gel + PRGF therapy, 30% and 70% of patients referred to be very satisfied, respectively. Accordingly, 40% and 80% showed a “very improved” esthetic performance. None of the patients reported a negative change and no adverse events were recorded. Conclusion Both Endoret‐Gel monotherapy and the combined treatment with PRGF were shown to promote facial rejuvenation and to palliate the age‐related cutaneous atrophy. The combined therapy may exert a synergistic effect that addresses both skin quality improvement and soft tissue restoration in a shorter period.

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“…Há uma evidente busca por procedimentos que sejam seguros, toleráveis e pouco invasivos. Nos últimos anos, a terapia com Plasma Rico em Plaquetas emergiu como uma modalidade de tratamento na área da dermatologia e estética devido à capacidade de induzir o crescimento celular na pele, retardando e atenuando o processo de envelhecimento (AMINI et al, 2015;FEDYAKOVA et al, 2018). O plasma rico em plaquetas é um concentrado de plaquetas derivado do sangue autógeno obtido pelo processo de centrifugação.…”

Section: Introductionunclassified

O uso do plasma rico em Plaquetas no Rejuvenescimento Facial: Uma Revisão Integrativa / Use of rich Plasma on platelets in Facial Rejuvenation: An Integrating Review

et al. 2019

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O plasma rico em plaquetas é um concentrado autólogo de plaquetas e fatores de crescimento. Tem sido utilizado há décadas em várias especialidades da área da saúde e, recentemente, evidências para aplicações na área estética vêm sendo desenvolvidas. Assim, o objetivo do estudo foi realizar uma revisão integrativa sobre o uso intradérmico do plasma rico em plaquetas para rejuvenescimento facial, baseado em evidências clínicas. Nove estudos foram incluídos na síntese interpretativa. Foram encontradas diferenças entre o método de obtenção do plasma, doses e o tamanho da amostra, que variou de 10 a 31 indivíduos, tornando os resultados com evidência pouco suficiente. Entretanto, a melhora na aparência da pele e das rugas foi estatisticamente significativa em todos os estudos, tanto após administrações únicas quanto após mais sessões de tratamento, o que demonstra a aplicação promissora do plasma rico em plaquetas, que pode ser integrado na prática estética para o rejuvenescimento facial.

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An autologous protein gel for soft tissue augmentation: in vitro characterization and clinical evaluation

Abstract: This novel injectable formulation has desirable mechanical and bioactive properties for 3D tissue regeneration and might offer a safe and effective treatment for depressed areas of the skin.

Cited by 17 publications

References 51 publications

Plasma rich in growth factor gel as an autologous filler for facial volume restoration

Plasma rich in growth factor gel as an autologous filler for facial volume restoration

Combined therapy with Endoret‐Gel and plasma rich in growth factors vs Endoret‐Gel alone in the management of facial rejuvenation: A comparative study

O uso do plasma rico em Plaquetas no Rejuvenescimento Facial: Uma Revisão Integrativa / Use of rich Plasma on platelets in Facial Rejuvenation: An Integrating Review

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