Abstract-Real-time detection and recognition of road traffic signs plays an important role in advanced driving assistance system. Typically, the region of interest (ROI) method is effective in feature extraction but inefficient because it is sensitive to illumination changes. In this paper, we propose a maximally stable extremal regions (MSER) method with image enhancement to greatly improve ROI. Firstly, we employ gray world algorithm to process original images. And then potential areas of traffic signs are obtained through increasing the image contrast ratio and extracting the image-enhanced MSER. According to the characteristic variable and the geometry moment invariants, the geometric characteristics of traffic signs are extracted to obtain the ROIs. Finally, HSV-HOG-LBP feature is constructed and the random forests algorithm is used to identify the traffic signs. The experimental results show that our proposed method show strong robustness on illumination condition and rotation scale, and achieves a good performance by experiments with actual images and German traffic sign detection benchmark (GTSDB) data set.