An autopsy case of rhabdomyolysis related to vegetamin and genetic analysis of the rhabdomyolysis-associated genes

Matsusue, Aya; Hara, Kenji; Kageura, Mitsuyoshi; Kashiwagi, Masayuki; Wang, Lu; Ishigami, Akiko; Gotohda, Takako; Tokunaga, Itsuo; NISIMURA, Akiyoshi; Sugimura, Tomoko; Kubo, Shin‐ichi

doi:10.1016/j.jflm.2009.07.020

Cited by 6 publications

(3 citation statements)

References 22 publications

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“…In intoxication cases, the frequency of the homozygous CYP2D6*2/*2 genotype is 0.126 [24]. Other studies also shown that some drugrelated deaths can be explained by the presence of the CYP2D6*2 haplotype [4,5,25]. In this study, the frequency of CYP2D6*2 (rs16947A !…”

Section: Discussionsupporting

confidence: 49%

Analysis of 50 SNPs in CYP2D6, CYP2C19, CYP2C9, CYP3A4 and CYP1A2 by MALDI-TOF mass spectrometry in Chinese Han population

Shi

Xiang

et al. 2011

Forensic Science International

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Section: Discussionsupporting

confidence: 49%

Analysis of 50 SNPs in CYP2D6, CYP2C19, CYP2C9, CYP3A4 and CYP1A2 by MALDI-TOF mass spectrometry in Chinese Han population

Shi

Xiang

et al. 2011

Forensic Science International

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“…This suggests that ORP150 mRNA expression is delayed, as based on the Hypoxyprobe results, the cells become hypoxic from 16 h. Notably, ORP150 expression reduced over time under normoxic and hypoxic conditions. Unlike additionally cell types including Hela cells (49), neuronal cells (50)(51)(52), renal cells (53) and cardiomyocytes (54,55), in MLO-Y4 cells ORP150 does not appear to be regulated by hypoxia at early time points. Similar results were identified for the ORP150 protein expression in pre-osteoblasts grown under hypoxic conditions compared with normoxic conditions.…”

Section: Discussionmentioning

confidence: 84%

Hypoxia mediates osteocyte ORP150 expression and cell death in vitro

Montesi

Jähn

Bonewald

et al. 2016

Molecular Medicine Reports

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Abstract. Skeletal unloading leads to hypoxia in the bone microenvironment, resulting in imbalanced bone remodeling that favors bone resorption. Osteocytes, the mechanosensors of bone, have been demonstrated to orchestrate bone homeostasis. Hypoxic osteocytes either undergo apoptosis or actively stimulate osteoclasts to remove bone matrix during hypoxia. Oxygen-regulated protein 150 (ORP150) is an endoplasmic reticulum-associated chaperone that has been observed to serve an important role in the cellular adaptation to hypoxia and in preventing cellular apoptosis in various tissue types. The current study hypotheses that expression of ORP150 would be increased in osteocytes under hypoxic conditions (1% O 2 ). The MLO-Y4 osteocyte cell line was cultured under normoxic or hypoxic conditions for up to 72 h. It was demonstrated that 1% O 2 significantly induced hypoxia after 16 h and up to 72 h, significantly reduced cell number at 8 and 48 h, induced cell death at 8, 24 and 48 h and induced apoptosis at 16, 24 and 48 h. Significant differences in ORP150 mRNA were observed at 72 h, however no differences were observed in the protein expression levels. The relative increase in ORP150 mRNA observed in hypoxia, compared with normoxia, may support its cytoprotective role in oxygen-deprived conditions.

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“…NMS is one of the severe complications associated with psychotropic drugs. We previously reported a postmortem diagnosis of NMS [17] and genetic approach to diagnose NMS [18][19][20]. The criteria of NMS are shown in Table 4.…”

Section: Differential Diagnosis For Ss Nms and Rhabdomyolysismentioning

confidence: 99%

An autopsy case of serotonin syndrome induced by illegal antipsychotics

Takayama¹,

Waters²,

Hara³

et al. 2017

RJLM

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Serotonin syndrome is a documented side effect of the use of serotonergic agents. We herein reported an autopsy case of serotonin syndrome (SS), revealed by autopsy findings and a toxicological analysis. A female in her late twenties was discovered lying dead in her kitchen in early June. The room was unkempt, with household belongings scattered about. Illegal herbs and a large number of drug tablets and capsules were discovered in her room. Her thoracoabdominal region had putrefactive discoloration, accompanied by vesicles and abrasions. Many wounds, discolorations, bruises, and muscle hemorrhages were observed on her body. No clear lesions were detected on any of the internal organs. A toxicological screening analysis identified several selective serotonin reuptake inhibitors (SSRIs) in her blood and urine, specifically fluoxetine (SSRI), citalopram (SSRI), diphenhydramine (antihistamine: AH), venlafaxine (serotonin noradrenaline reuptake inhibitor: SNRI), and chlorpheniramine (AH). A quantitative analysis was performed using liquid chromatography coupled with tandem mass spectrometry. Most of the drugs detected were at lethal concentrations. Serotonergic agent intoxication induces SS, a condition accompanied by symptoms such as confusion and agitation. Since many blunt force injuries were observed on her body, she may have fallen into an excited and confused state just before her death, and, in a wild rage, scattered her belongings about and injured herself, thereby causing the many wounds on her body. The cause of death was multiple drug intoxication with SS.

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An autopsy case of rhabdomyolysis related to vegetamin and genetic analysis of the rhabdomyolysis-associated genes

Cited by 6 publications

References 22 publications

Analysis of 50 SNPs in CYP2D6, CYP2C19, CYP2C9, CYP3A4 and CYP1A2 by MALDI-TOF mass spectrometry in Chinese Han population

Analysis of 50 SNPs in CYP2D6, CYP2C19, CYP2C9, CYP3A4 and CYP1A2 by MALDI-TOF mass spectrometry in Chinese Han population

Hypoxia mediates osteocyte ORP150 expression and cell death in vitro

An autopsy case of serotonin syndrome induced by illegal antipsychotics

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