An autopsy case of triple cancers including signet-ring cell carcinoma of the breast —Report of a rare case with reference to a review of the literature—

Misonou, Jun; Kanda, Makoto; Miyake, Takayoshi; Kawamura, Tsugumichi; Maekawa, I; Hishiyama, Houhei; Atsuta, Tomoyoshi

doi:10.1007/bf02471041

Cited by 6 publications

(3 citation statements)

References 9 publications

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“…This type of tumor accounts for approximately 1% of all breast cancer cases (29,39,41). It is characterized by a particularly high proportion of signet-ringshaped cells and is considered as a subtype of lobular carcinoma (39,40,(42)(43)(44)(45)(46)(47). Moreover, after searching the PubMed, Embase and Web of science databases, we found that SRCs may occur in metastases only and not in the primary tumors (39,48).…”

Section: Discussionmentioning

confidence: 88%

Case Report: Metastatic Signet-Ring-Cell Carcinoma of the Bladder From Breast Invasive Lobular Carcinoma Detected by Computed Tomography

et al. 2022

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Secondary bladder tumors are relatively rare among all bladder tumors, while bladder metastases from breast cancer have been rarely reported. Furthermore, signet-ring differentiation may appear in the metastases from a breast invasive lobular carcinoma regardless of whether the primary breast tumor had signet-ring cells, which may cause diagnostic uncertainty. We report a case of a 55-year-old female patient with diffuse bladder thickening as the chief complaint and no specific clinical manifestations. While the cystoscopy showed multiple scattered red protuberances, the biopsy suggested signet-ring-cell carcinoma. The gastroscopy results suggested poorly differentiated adenocarcinoma with signet-ring cells. Considering the patient’s history of invasive lobular carcinoma of the breast, chronic myeloid leukemia, and metastatic endometrial carcinoma from the breast, we performed an immunohistochemical analysis and the results indicated that signet-ring-cell carcinomas of the stomach and bladder originated from the invasive lobular carcinoma of the breast. We performed positron emission tomography/computed tomography and the results showed that there were multiple bone metastases already present. This was the first English case report of invasive lobular carcinoma of the breast metastasizing to the uterus, stomach, bladder, and bones with multiple signet-ring-cell variations. This study shares our reasons for misdiagnosing and opinions on diagnosing and treating for this kind of cases.

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Section: Discussionmentioning

confidence: 88%

Case Report: Metastatic Signet-Ring-Cell Carcinoma of the Bladder From Breast Invasive Lobular Carcinoma Detected by Computed Tomography

et al. 2022

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“…This type of tumor accounts for approximately 1% of all breast cancer (29,37,39). It is characterized by a particularly high proportion of signet-ring-shaped cells and is considered as a subtype of lobular carcinoma (37,38,(40)(41)(42)(43)(44)(45).…”

Section: Discussionmentioning

confidence: 99%

Metastatic Signet-Ring-Cell Carcinoma of Bladder From Breast Invasive Lobular Carcinoma Found By CT: A Case Report And Literature Review

Jin

Tang

Chen

et al. 2021

Preprint

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Background: Secondary bladder tumors are relatively rare in all bladder tumors, while bladder metastases from breast cancer were rarely reported. And interestingly, signet-ring differentiation may appear in metastases from a breast invasive lobular carcinoma regardless of whether or not the primary breast tumor had signet-ring cells, which may cause diagnostic uncertainty.Case presentation: We report a case of a 55-year-old female patient with diffuse bladder thickening as the chief complaint. There was no special clinical manifestation, while cystoscopy showed multiple scattered red protuberances and the biopsy suggested signet-ring-cell carcinoma. Result of gastroscopy suggested poorly differentiated adenocarcinoma with signed-ring cells. Considering the patient's previous history of invasive lobular carcinoma of the breast, chronic myeloid leukemia and metastatic endometrial carcinoma from the breast, we performed the immunohistochemistry and the results indicated that signet-ring-cell carcinomas of the stomach and bladder originated from the breast invasive lobular carcinoma. we performed Positron Emission Tomography/Computed Tomography (PET/CT) and the results showed that there were multiple bone metastases already.Conclusion: This is the first English case report of invasive lobular carcinoma of breast metastasizing to uterus, stomach, bladder and bones with multiple signet-ring-cell variations. We also focus on the Computed Tomography (CT), immunohistochemistry (IHC) and cystoscopy findings and share the clinical diagnosis ideas summarized by this case.

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“…More than 80 cases of signet‐ring cell carcinoma of the breast have been reported in the English literature. 1,3,4,6–22 Although the prevalence of signet‐ring cell carcinoma has varied from 2% to 4.5% of total breast cancers, 1,23 pure form signet‐ring cell carcinoma is very rare. To date, only a few cases have been reported in the English literature.…”

Section: Discussionmentioning

confidence: 99%

Signet‐ring cell carcinoma of the breast

Liu¹,

Chen

2000

Pathology International

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Primary signet-ring cell carcinoma of the breast is a very rare tumor and is not recognized as an independent entity of the World Health Organization classification of breast tumor. Primary signet-ring cell carcinoma of the breast is usually considered as a variant of mucinous carcinoma or lobular carcinoma and usually originates from the lobular epithelium. A case of primary signet-ring cell carcinoma of the breast in a 68-year-old woman is presented. Histologically, the majority of neoplastic cells had an intracytoplasmic mucin collection. The histological presence of ductal carcinoma in situ, absence of lobular lesion and immunoreactivity for estrogen and progesterone receptors implicated the tumor cells arising from ductal epithelium. The papillary or organoid growth pattern is characteristic in this case. The patient underwent a modified radical mastectomy and was subsequently followed up for 6 months.

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An autopsy case of triple cancers including signet-ring cell carcinoma of the breast —Report of a rare case with reference to a review of the literature—

Cited by 6 publications

References 9 publications

Case Report: Metastatic Signet-Ring-Cell Carcinoma of the Bladder From Breast Invasive Lobular Carcinoma Detected by Computed Tomography

Case Report: Metastatic Signet-Ring-Cell Carcinoma of the Bladder From Breast Invasive Lobular Carcinoma Detected by Computed Tomography

Metastatic Signet-Ring-Cell Carcinoma of Bladder From Breast Invasive Lobular Carcinoma Found By CT: A Case Report And Literature Review

Signet‐ring cell carcinoma of the breast

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