Signet‐ring cell carcinoma of the breast

Liu, Shian-Min; Chen, Dar Ren

doi:10.1046/j.1440-1827.2000.01007.x

Cited by 29 publications

(20 citation statements)

References 17 publications

(28 reference statements)

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“…1 Signet-ring cell carcinomas can arise in a wide variety of organs, including lung, [2][3][4][5][6] stomach, 7,8 colon, [8][9][10] breast, 8,11,12 urinary bladder, [13][14][15][16][17] pancreas, 18 salivary glands, 19 and prostate. [20][21][22][23][24][25][26][27][28] The signet-ring configuration seen in adenocarcinomas has traditionally been associated with the accumulation of large amounts of intracytoplasmic mucin.…”

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confidence: 99%

Mesothelioma with signet-ring cell features: report of 23 cases

Ordóñez

2013

Modern Pathology

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Signet-ring cell mesothelioma is uncommon and only two case reports have been published on this mesothelioma variant, both of which were initially misdiagnosed as signet-ring cell carcinoma. Herein are reported 23 signet-ring cell mesotheliomas that were investigated by immunohistochemistry, 12 of which were also studied by electron microscopy. Twenty-one of the cases originated in the pleura and two in the peritoneum. For comparison purposes and in order to determine the value of these techniques in the differential diagnosis of these tumors, seven cases of signet-ring cell lung adenocarcinoma were also studied. All signetring cell mesotheliomas were positive for calretinin, keratin 5/6, keratin 7, and mesothelin, 93% for podoplanin, and 91% for WT1; whereas, none reacted for MOC-31, CEA, TAG-72, CD15, TTF-1, napsin A, or CDX2. Among signet-ring cell lung adenocarcinomas, 100% were positive for keratin 7, CEA, and napsin A, 86% each for TTF-1 and TAG-72, 71% for CD15, and 14% for mesothelin, while all were negative for calretinin, keratin 5/6, WT1, podoplanin, and CDX2. After analyzing the results, it is concluded that the panels of markers used in the differential diagnosis of this mesothelioma variant should include those markers that are usually expressed in mesotheliomas (eg, calretinin, keratin 5/6, WT1, and podoplanin), broad-spectrum carcinoma markers that are frequently expressed in adenocarcinomas regardless of their site of origin (eg, MOC-31 and CEA), and organ-associated markers (eg, TTF-1 and napsin A for lung), which allow the site of origin of a metastatic adenocarcinoma to be established. Electron microscopy can be very useful as it permits the identification of characteristic ultrastructural mesothelioma and adenocarcinoma markers, and it also allows a better understanding of the morphologic features seen on routine light microscopy. Pathologists should be aware of this mesothelioma subtype as it can potentially be confused with other tumors that exhibit signet-ring features. Modern Pathology (2013) 26, 370-384; doi:10.1038/modpathol.2012.172; published online 5 October 2012Keywords: electron microscopy; immunohistochemistry; signet-ring cell carcinoma; signet-ring cell mesotheliomaThe finding of occasional vacuolated cells exhibiting signet-ring-like morphology is not rare in mesotheliomas; however, epithelioid mesotheliomas having a large number of such cells are relatively uncommon and have been subclassified as signet-ring cell mesotheliomas. 1 Signet-ring cell carcinomas can arise in a wide variety of organs, including lung, 2-6 stomach, 7,8 colon, 8-10 breast, 8,11,12 urinary bladder, 13-17 pancreas, 18 salivary glands, 19 and prostate. [20][21][22][23][24][25][26][27][28] The signet-ring configuration seen in adenocarcinomas has traditionally been associated with the accumulation of large amounts of intracytoplasmic mucin. It can also occur as a result of the formation of a true intracytoplasmic lumen with displacement of the nucleus toward the periphery of the cell, in which case, spe...

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Mesothelioma with signet-ring cell features: report of 23 cases

Ordóñez

2013

Modern Pathology

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“…They are of course best known for their occurrence as mucin-positive, neoplastic cells in the diffuse variant of gastric adenocarcinoma-the classic signet ring cell carcinoma. Similar cells may be seen in neoplasms derived from many other organs, [1][2][3]7,9,[12][13][14]22,23,30,31,37,39,40,42,47,49,51,59,60 and there are numerous pitfalls associated with the diagnosis in such cases including, but not limited to, the sometimes dispersed, scant number of cells, their deceptive cytology, The accumulation of large mucin vacuoles in nonneoplastic epithelial cells, usually in inflammatory gastrointestinal diseases, may result in ''signet ring cell change,'' a potential simulator of carcinoma. 11,17,65 Non-neoplastic histiocytes, which have engulfed polyvinylpyrrolidone, resulting in ''mucicarminophilic histiocytosis,'' may also produce a deceptive signet ring appearance, 33 and the common adenomatoid tumor may also have conspicuous foci of signet ring cells containing hyaluronic acid.…”

Section: Discussionmentioning

confidence: 80%

Seminoma With Conspicuous Signet Ring Cells: A Rare, Previously Uncharacterized Morphologic Variant

Ulbright

Young

2008

American Journal of Surgical Pathology

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We report 2 seminomas with conspicuous numbers of signet ring cells. The tumors occurred in men, 24 and 69 years of age, who presented with testicular masses; 1 seminoma was a component of a mixed germ cell tumor and the other was pure. The signet ring cells occurred in a multifocal fashion in areas of otherwise typical seminoma and comprised approximately 70% and 10%, respectively, of the tumors. They had large, translucent to clear cytoplasmic vacuoles that compressed the nuclei to a peripheral crescent. In 1 case, the vacuoles contained numerous refractile, nonpolarizable globular deposits that were shown to be glycogen on the basis of periodic acid-Schiff stain positivity that was abolished by pretreatment with diastase; in the second case, they mostly appeared "empty" and lacked periodic acid-Schiff positivity. The signet ring cells were mucicarmine, cytokeratin (AE1/3) and alpha-fetoprotein negative, but positive for OCT3/4 and CD117, the latter 2 being expected for seminoma cells. A review of 30 randomly selected seminomas identified very rare, inconspicuous signet ring cells in 43%. The presence of prominent signet ring cells in seminoma may cause confusion as it has not been described previously in detail, and a variety of neoplasms, particularly metastasis, may be considered. The description of this phenomenon expands the known morphologic spectrum of the most common testicular neoplasm.

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“…Primary SRCC of the breast is a very rare tumor, which shows a significant number of tumor cells with intracellular mucin accumulation [2,3]. In 1941, Saphir first described this type of tumor as a variety of mucinous carcinoma [4].…”

Section: Introductionmentioning

confidence: 99%