Signet-ring cell carcinoma of the breast: a case report

Xing, Ling; Feng, Yan; Wei, Wei Dong; Liu, Peng; Xie, Ze Ming; Wang, Jin; Xie, Xiao

doi:10.1186/1477-7819-11-183

Cited by 18 publications

(13 citation statements)

References 14 publications

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“…While estrogen receptor (ER) is most often positive in breast SRCCs, it can be negative in up to 20% of cases [ 43 ]. CK7 and CK20 expression patterns can often help in distinguishing from a gastric or colonic source [ 44 ]. The majority of ovarian SRCCs are metastatic from other primary lesions, typically of the gastrointestinal tract (Krukenberg tumors) [ 45 ].…”

Section: Discussionmentioning

confidence: 99%

Epidemiology of Signet Ring Cell Adenocarcinomas

Benesch

Mathieson

2020

Cancers

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Signet ring cell adenocarcinomas (SRCCs) are a rare histological subtype of adenocarcinomas with a poor prognosis, typically due to advanced disease at diagnosis. A signet ring cell, mimicking its moniker, contains abundant intracytoplasmic mucin that pushes the nucleus to the periphery. In these cancers, this cell feature comprises more than 50% of the tumor. Despite predilection for the gastrointestinal tract, and in particular the stomach, primary SRCCs are also described in other sites, typically in case reports. This literature, however, lacks a standardized overview of the SRCC disease entity. Using a retrospective cohort approach, we summarize the clinicodemographic and mortality outcomes of SRCCs in thirteen primary sites, comprising 95% of all SRCCs in the Surveillance, Epidemiology, and End Results Program (SEER), a population-level cancer database covering nearly one-third of the United States population. SRCCs general trends compared to matching nonvariant adenocarcinomas are earlier age of onset, with initial presentation favoring higher rates of regional or distant disease presentation and poor tumor differentiation. After multivariable analysis, SRCCs typically have worse overall survivals, but substantial variances exist depending on tumor location. Identifying SRCCs at earlier disease stages is likely the single most important intervention to improving outcomes for these patients.

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Section: Discussionmentioning

confidence: 99%

Epidemiology of Signet Ring Cell Adenocarcinomas

Benesch

Mathieson

2020

Cancers

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“…Signet ring cell carcinomas most commonly occur in the stomach, accounting for 15%-30% of gastric cancers (1), and less frequently in the colon, representing 1%-2% of all colorectal malignancies (2). Although reported, other primary sites of SRCC occurrence such as breast, prostate, appendix, or lung are very rare (3)(4)(5)(6). Therefore SRCC is rarely thought of as a possible histologic type of tumor causing obstructive jaundice and may be mistakenly interpreted both macroscopically and on histopathology as inflammation (1).…”

Section: Discussionmentioning

confidence: 99%

Primary Signet Ring Cell Carcinoma of the Pancreas with a Good Response to Chemotherapy: Case Report and Literature Review

Radojković

Ilić²,

Ilić

2017

Tumori

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Significant tumor downsizing in our patient clearly demonstrates good response to neoadjuvant gemcitabine monotherapy. The optimal preoperative chemotherapy leading to tumor reduction and disease control in patients with borderline resectable and locally advanced pancreatic carcinoma is controversial, necessitating further randomized studies including combined chemoradiotherapy and multidrug combination regimens.

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“…Immunophenotype: ER is very often positive. High intensity MUC 1 positivity distinguishes primary signet ring cell carcinoma from metastatic deposits [11].…”

Section: Epidemiology: Variable From 2-45%mentioning

confidence: 99%

Institutional Spectrum of Rare Histological Types of Breast Carcinoma

P¹,

S²,

Chaitanya³

2019

SJPM

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Background: Invasive breast cancer is a heterogeneous disease in its presentation, pathological classification and clinical course. Most tumors are derived from mammary ductal epithelium, principally the terminal duct-lobular unit. However, there are more than a dozen histological variants which are less common but still very well defined by the World Health Organization (WHO) classification. The prime objective of the current study is to document our institutional experience of such rare histological entities with review of literature of the same. Methods: The clinicopathological records of resected breast lesions submitted to histopathology department over the period of three years from Jan 2016 to December 2018 were reviewed retrospectively. It was observational, retrospective and descriptive analysis of 4 unusual histological types of breast carcinoma. The most common lesions like infiltrating ductal carcinoma (IDC) and infiltrating lobular carcinoma in malignant category and benign lesions were excluded from the study. Results: Among 528 breast malignancies reported in the institute, 48 unusual histological types were recognized, of which 4 are very rare histological types with less than 1% incidence. Conclusions: Here in we highlighted the rare varieties of cribriform, squamous, apocrine and signet ring cell carcinoma of breast with relevance to clinical, histopathological and immunohistochemical features. It is with significance to the fact that histological diversity of breast carcinoma has relevant prognostic implications.

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Signet-ring cell carcinoma of the breast: a case report

Cited by 18 publications

References 14 publications

Epidemiology of Signet Ring Cell Adenocarcinomas

Epidemiology of Signet Ring Cell Adenocarcinomas

Primary Signet Ring Cell Carcinoma of the Pancreas with a Good Response to Chemotherapy: Case Report and Literature Review

Institutional Spectrum of Rare Histological Types of Breast Carcinoma

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