An Autoradiographic Study of the Sensory Innervation of Teeth. I. Dentin

Pimenidis, Margaritis Z.; Hinds, James W.

doi:10.1177/00220345770560071901

Cited by 23 publications

(6 citation statements)

References 26 publications

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“…This restriction to the inner regions is in general agreement with the findings of Fearnhead (19571, who describes axons at a maximum distance of 0.4 mm beyond the predentin and with the autoradiographic results of Byers (1977). Two other autoradiographic tracer studies in the rat (Quinton-Cox, 1975;Pimendis and Hinds, 1977) describe labeled material in the outer dentin near to enamel-dentin junction. In this and earlier studies (Brannstrom and Garberoglio, 1974;Holland, 1976c) no cell processes have been seen in this region.…”

Section: Discussionmentioning

confidence: 99%

The incidence of dentinal tubules containing more than one process in the cuspal dentin of cat canine teeth

Holland

1981

Anat. Rec.

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The incidence of multiple processes within the tubules of the cuspal dentin of the cat's canine has been measured by counting directly from ultrathin sections examined in the electron microscope. The incidence is highly variable. The greatest incidence was found 1 mm below the cuspal dentino enamel junction where up to 75% of tubules in some areas contain more than one process. On average 33.6% of the tubules at this level contain multiple processes. The incidence declines linearly toward the apex with virtually no multiple processes occurring at 4 mm below the tip dentino enamel junction or beyond. Half of the "second processes" contain either mitochondria and/or vesicles. They are restricted to predentin where many of them end and to inner calcified dentin. Their distribution is similar to that described for nerve fibers in other studies. None of the processes participated in specialized junctions.

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Section: Discussionmentioning

confidence: 99%

The incidence of dentinal tubules containing more than one process in the cuspal dentin of cat canine teeth

Holland

1981

Anat. Rec.

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“…Their central processes pass to the Main Sensory Trigeminal Nucleus (MSTN) while others pass to the Spinal Tract of the Trigeminal Nucleus (STTN). Autoradiographic studies have shown that the afferent nerves from periodontal receptors end in the Gasserian ganglion (Pimenidis & Hinds 1977, Byers & Holland 1977). It appears from the first study, that by labeling the cells in the Gasserian ganglion with tritiated L-Proline, the periodontal ligament is only moderately labelled, while the labeling of the free gingiva is prominent.…”

Section: Central Connectionsmentioning

confidence: 99%

The structure and function of periodontal innervation

Steenberghe

1979

J of Periodontal Research

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The histology of periodontal innervation in man and of the neural endings in the periodontal ligament in particular remains a controversial matter. Quantitative ultrastructural studies are needed and would help clarifying some functional characteristics of periodontal mechanoreceptors. Most of these characteristics are comparable to those of tegumental receptors elsewhere in the body. Some discrepancies exist however between the findings in perpheral afferent nerves and the findings in the intra‐crainal centres. Concerning the functional significance of periodontal reeceptors, the jaw‐opening reflex and the silent period in jaw muscle activity are related to each other, and their importance is questioned. Although much work has been accomplished on the silent period, the concurrent monosynaptic reflex has been mostly neglected and it has not been demonstrated whether periodontal receptors are the only origin of these reflexes. The perdominant role of periodontal receptors in detecting and discriminating forces acting on a tooth and in the control of the mandibular position when an occlusal contact is present has been proven.

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“…So far, autoradiography of rat molars (Fink et al, 1975;Byers and Kish, 1976;Pimenidis and Hinds, 1977;Byers, 1977Byers, , 1979Byers, , 1980Byers et al, 1982b) and of cat teeth (Byers and Matthews, 1981) has shown that dentin is innervated, that nerve endings are most numerous in the tubular dentin near the tip of the pulp horn, that some nerve endings can be found in radicular dentin, and that a few axons cross the midline in cats to innervate contralateral incisors (for review, Byers, 1983).…”

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Autoradiographic location of sensory nerve endings in dentin of monkey teeth

Byers

Dong

1983

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We have used the autoradiographic method to locate trigeminal nerve endings in monkey teeth. The nerve endings were labeled in two adult female Macaca fascicularis by 20 hours of axonal transport of radioactive protein (3H-L-proline). We found a few labeled axons in contralateral mandibular central incisors and one mandibular canine. In ipsilateral teeth, numerous myelinated and unmyelinated axons were labeled; they formed a few terminal branches in the roots but primarily branched in the crown to form the peripheral plexus of Raschkow and to terminate as free endings in the odontoblast layer, predentin, and as far as 120 micrometers into dentinal tubules. Electron microscopic autoradiography showed that the radioactive axonally transported protein was confined to sensory axons and endings; odontoblasts and dentin matrix were not significantly labeled. Labeled free nerve endings were closely apposed to odontoblasts in dentin but did not form distinctive junctions with them. Nerve endings were most numerous in the regular tubular dentin of the crown adjacent to the tip of the pulp horn, occurring in at least half of the dentinal tubules there. Reparative dentin was poorly innervated, even near the tip of the crown, and it had a different tubular structure and adjacent pulpal structure from the innervated dentin. Radicular dentin was not innervated in most areas but did contain a few labeled axons where the predentin was wide and the odontoblasts were columnar, as at the buccal and lingual poles of some roots. Our results show tha dentinal sensory nerve endings in primate teeth can be profuse, sparse, or absent depending on the location and structure of dentin and its adjacent pulp. When dentin was innervated, the tubules were straight and contained odontoblast processes, the predentin was wide, the odontoblast cell bodies were relatively columnar, and there was an adjacent cell-free zone and pulpal nerve plexus.

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An Autoradiographic Study of the Sensory Innervation of Teeth. I. Dentin

Abstract: Autoradiography of axoplasmically transported proteins revealed that the coronal dentin of rat molar teeth receives sensory innervation from the trigeminal ganglion. The labeled processes appear to run in dentinal tubules and sometimes reach the peripheral dentinal region near the enamel.

Cited by 23 publications

References 26 publications

The incidence of dentinal tubules containing more than one process in the cuspal dentin of cat canine teeth

The incidence of dentinal tubules containing more than one process in the cuspal dentin of cat canine teeth

The structure and function of periodontal innervation

Autoradiographic location of sensory nerve endings in dentin of monkey teeth

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