An Autoradiographic Study of the Sensory Innervation of Teeth. II. Dental Pulp Periodontium

Pimenidis, Margaritis Z.; Hinds, James W.

doi:10.1177/00220345770560072001

Cited by 14 publications

(5 citation statements)

References 21 publications

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“…We have found that the sensory innervation of adult dog teeth is similar to that reported earlier for rat molars (Fink et al, 1975;Byers and Kish, 1976;Pimenidis and Hinds, 1977), cat teeth (Byers and Matthews, 1981), and monkey teeth (Byers and Dong, 1983). Most of the sensory axons arborize in the coronal pulp, and numerous nerve terminals are found in its peripheral plexus and extending into inner dentin.…”

Section: Discussionsupporting

confidence: 85%

“…The location of sensory receptors has also been studied extensively since the mid-1960s in human, cat, and rodent teeth, with much information derived from light and electron microscopy @ ' earnhead, 1963;Frank, 1968;Arwill et al, 1973;Corpron and Avery, 1973; Dahl and Mjor, 1973;Lilja, 1979; Byers et al, 1982) and axonal transport labeling (Fink et al, 1975;Byers and Kish, 1976; Pimenidis and Hinds, 1977; Byers, 1977Byers, , 1980Byers, , 1984Byers, ,1985; Byers and Matthews, 1981; Byers and Dong, 1983; Marfurt and Turner, 1983). Sensory fibers have been found to innervate peripheral pulp and to extend as far as 0.1-0.2 mm into dentinal tubules.…”

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confidence: 99%

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Sensory innervation of pulp and dentin in adult dog teeth as demonstrated by autoradiography

1987

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In order to study the location of sensory nerve fibers in dog teeth, we injected 3H-amino acids into the left trigeminal ganglion of 2 anesthetized adult dogs; we then waited 24 hours for axonal transport of labeled protein and prepared the fixed decalcified teeth for autoradiography. Heavily labeled sensory neurons were found in the maxillary and mandibular divisions of each injected ganglion and its peripheral nerves and central root. Numerous labeled axons were found entering dental roots; they arborized mostly in the crown to end in peripheral pulp or inner dentin. Some labeled fibers extended 150-175 microns into dentinal tubules, but most intradentinally labeled fibers were less than 100 microns long. The dentinal innervation was most concentrated in the crown, with autoradiographic label over more than 50% of the tubules at the tip of each pulp horn. Differences in innervation density for coronal, cervical, intercuspal, septal, radicular, and reparative dentin were analyzed. In some regions, labeled endings branched along the pulp-predentin border but did not enter the dentinal tubules. Electron microscopic autoradiograms were prepared to confirm specific labeling of nerve fibers and nerve endings, and to describe their ultrastructure and association with odontoblasts. The results show that labeled sensory fibers in dog teeth have an ultrastructure similar to that described previously for rat molars and for monkey and cat teeth. No specific junctions were found between labeled sensory fibers and odontoblasts, in agreement with previous studies of other teeth.

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Section: Discussionsupporting

confidence: 85%

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confidence: 99%

Sensory innervation of pulp and dentin in adult dog teeth as demonstrated by autoradiography

1987

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“…22 In the root dentin and cementum, however, newlyformed collagen is apparently labeled, perhaps by release of H3-proline from nerve terminals and possibly reflecting a neurotropic relationship. Such a neurotropic relationship would be consistent with the findings of Stopakoff and Stiefe148 who have reported that sensory denervation affects the calcification process of dog's dentin.…”

Section: Resultsmentioning

confidence: 99%

An Autoradiographic Study of the Sensory Innervation of Teeth. I. Dentin

Pimenidis

Hinds

1977

J Dent Res

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“…For rodent lower incisor, it is innervated by sensory nerve fibres which come from IAN, sympathetic postganglionic fibres which origin from SCG and a few parasympathetic nerve fibres which are still under controversial 25 . The sensory nerve primarily governs the sense of pain, the pressure and vasodilatation regulation, 4,27 while the sympathetic nerve tends to regulate vasoconstriction functions 5,28 . Though it has been reported IANx leads to slower incisor eruption and tooth discoloration, 23 whether sympathetic nerve participate in incisor growth remains unclear.…”

Section: Discussionmentioning

confidence: 99%

Sensory nerve‐deficient microenvironment impairs tooth homeostasis by inducing apoptosis of dental pulp stem cells

et al. 2020

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Objectives:The aim of this study is to investigate the role of sensory nerve in tooth homeostasis and its effect on mesenchymal stromal/stem cells (MSCs) in dental pulp. Materials and methods:We established the rat denervated incisor models to identify the morphological and histological changes of tooth. The groups were as follows:IANx (inferior alveolar nerve section), SCGx (superior cervical ganglion removal), IANx + SCGx and Sham group. The biological behaviour of dental pulp stromal/ stem cells (DPSCs) was evaluated. Finally, we applied activin B to DPSCs from sensory nerve-deficient microenvironment to analyse the changes of proliferation and apoptosis. Results: Incisor of IANx and IANx + SCGx groups exhibited obvious disorganized tooth structure, while SCGx group only showed slight decrease of dentin thickness, implying sensory nerve, not sympathetic nerve, contributes to the tooth homeostasis. Moreover, we found sensory nerve injury led to disfunction of DPSCs via activin B/SMAD2/3 signalling in vitro. Supplementing activin B promoted proliferation and reduced apoptosis of DPSCs in sensory nerve-deficient microenvironment. Conclusions: This research first demonstrates that sensory nerve-deficient microenvironment impairs tooth haemostasis by inducing apoptosis of DPSCs via activin B/ SMAD2/3 signalling. Our study provides the evidence for the crucial role of sensory nerve in tooth homeostasis.

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An Autoradiographic Study of the Sensory Innervation of Teeth. II. Dental Pulp Periodontium

Cited by 14 publications

References 21 publications

Sensory innervation of pulp and dentin in adult dog teeth as demonstrated by autoradiography

Sensory innervation of pulp and dentin in adult dog teeth as demonstrated by autoradiography

An Autoradiographic Study of the Sensory Innervation of Teeth. I. Dentin

Sensory nerve‐deficient microenvironment impairs tooth homeostasis by inducing apoptosis of dental pulp stem cells

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