An autosomal genetic linkage map of the sheep genome.

Crawford, A. M.; Dodds, K. G.; Ede, A J; Pierson, C. A.; Montgomery, G. W.; Garmonsway, H. G.; Beattie, A. E.; Davies, Katherine; Maddox, Jill F.; Kappes, S W

doi:10.1093/genetics/140.2.703

Cited by 305 publications

(19 citation statements)

References 74 publications

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“…Mate choice on the basis of MHC type was analysed using ¢ve polymorphic microsatellite loci located within or adjacent to the MHC in recent ovine genetic maps (Crawford et al 1995) as shown in ¢gure 1. The markers OLADRB and OLADRBps are located within MHC class II expressed and non-expressed genes respectively (Blattman & Beh 1992;Schwaiger et al 1993), OMHC1 is located within the MHC class I region (Groth & Wetherall 1994) and BM1815 and BM1818 (Bishop et al 1994) were used as £anking marker controls.…”

Section: (D) Mhc Markersmentioning

confidence: 99%

No evidence for major histocompatibility complex–dependent mating patterns in a free–living ruminant population

Paterson

Pemberton

1997

Proc. R. Soc. Lond. B

124

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Conventionally, the extraordinary diversity of the vertebrate major histocompatibility complex (MHC) is thought to have evolved in response to parasites and pathogens a¡ecting ¢tness. More recently, reproductive mechanisms such as disassortative mating have been suggested as alternative mechanisms maintaining MHC diversity. A large unmanaged population of Soay sheep (Ovis aries L.) was used to investigate reproductive mechanisms in the maintenance of MHC diversity. Animals were sampled as new-born lambs and between 887 and 1209 individuals were typed at each of ¢ve microsatellite markers located either within or £anking the ovine MHC. All loci were in Hardy^Weinberg proportions. A novel likelihood-based approach was developed to analyse mating patterns using paternity data. No evidence for non-random mating with respect to MHC markers was found using this technique. We conclude that MHC diversity in the St Kildan Soay sheep population is unlikely to be maintained by mating preferences and that, in contrast with evidence from experimental mice populations, MHC variation plays no role in the mating structure of this population.

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Section: (D) Mhc Markersmentioning

confidence: 99%

No evidence for major histocompatibility complex–dependent mating patterns in a free–living ruminant population

Paterson

Pemberton

1997

Proc. R. Soc. Lond. B

124

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“…Cross-species amplification of microsatellite loci has been reported within closely related livestock species [3,28,37] and has been exploited in the construction of genetic maps for cattle [17], sheep [9], and goats [42] in the Bovidae family. Exchanges of microsatellite markers have also been observed between related avian species [8,29,30,34].…”

Section: Introductionmentioning

confidence: 99%

Microsatellite loci in Japanese quail and�cross-species amplification in�chicken and�guinea fowl

et al. 2002

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In line with the Gifu University's initiative to map the Japanese quail genome, a total of 100 Japanese quail microsatellite markers isolated in our laboratory were evaluated in a population of 20 unrelated quails randomly sampled from a colony of wild quail origin. Ninety-eight markers were polymorphic with an average of 3.7 alleles per locus and a mean heterozygosity of 0.423. To determine the utility of these markers for comparative genome mapping in Phasianidae, cross-species amplification of all the markers was tested with chicken and guinea fowl DNA. Amplification products similar in size to the orthologous loci in quail were observed in 42 loci in chicken and 20 loci in guinea fowl. Of the cross-reactive markers, 57.1% in chicken and 55.0% in guinea fowl were polymorphic when tested in 20 birds from their respective populations. Five of 15 markers that could cross-amplify Japanese quail, chicken, and guinea fowl DNA were polymorphic in all three species. Amplification of orthologous loci was confirmed by sequencing 10 loci each from chicken and guinea fowl and comparing with them the corresponding quail sequence. The microsatellite markers reported would serve as a useful resource base for genetic mapping in quail and comparative mapping in Phasianidae.

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“…The United States Meat Animal Research Center (USMARC) and other US researchers were involved and contributed to the international mapping flock to create linkage maps (Crawford et al . 1995 ; de Gortari et al . 1998 ; Maddox et al .…”

Section: Progression Of Genomicsmentioning

confidence: 99%

Evolution of the sheep industry and genetic research in the United States: opportunities for convergence in the twenty‐first century

et al. 2021

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Summary The continuous development and application of technology for genetic improvement is a key element for advancing sheep production in the United States. The US sheep industry has contracted over time but appears to be at a juncture where a greater utilization of technology can facilitate industry expansion to new markets and address inefficiencies in traditional production practices. Significant transformations include the increased value of lamb in relation to wool, and a downtrend in large‐scale operations but a simultaneous rise in small flocks. Additionally, popularity of hair breeds not requiring shearing has surged, particularly in semi‐arid and subtropical US environments. A variety of domestically developed composite breeds and newly established technological approaches are now widely available for the sheep industry to use as it navigates these ongoing transformations. These genetic resources can also address long‐targeted areas of improvement such as growth, reproduction and parasite resistance. Moderate progress in production efficiency has been achieved by producers who have employed estimated breeding values, but widespread adoption of this technology has been limited. Genomic marker panels have recently shown promise for reducing disease susceptibility, identifying parentage and providing a foundation for marker‐assisted selection. As the ovine genome is further explored and genomic assemblies are improved, the sheep research community in the USA can capitalize on new‐found information to develop and apply genetic technologies to improve the production efficiency and profitability of the sheep industry.

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An autosomal genetic linkage map of the sheep genome.

Cited by 305 publications

References 74 publications

No evidence for major histocompatibility complex–dependent mating patterns in a free–living ruminant population

No evidence for major histocompatibility complex–dependent mating patterns in a free–living ruminant population

Microsatellite loci in Japanese quail and�cross-species amplification in�chicken and�guinea fowl

Evolution of the sheep industry and genetic research in the United States: opportunities for convergence in the twenty‐first century

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