An easy-to-use antimicrobial hydrogel effectively kills bacteria, fungi, and influenza virus

Bhattacharjee, Brinta; Jolly, Logia; Mukherjee, Riya; Haldar, Jayanta

doi:10.1039/d2bm00134a

Cited by 13 publications

(7 citation statements)

References 38 publications

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“…Nevertheless, it is important to bear in mind, that other new antimicrobial agents have also been developed, such as peptides, bacteriophages, immunomodulators, predatory microorganisms, and metal nanoparticles (Allen et al, 2014; Cheng et al, 2014; Cuadrado et al, 2022; Romero et al, 2020; Romero, Alves, et al, 2021; Romero, Buzza, et al, 2021), owing to the abuse in the use of conventional antibiotics, which has promoted multidrug‐resistant. This makes it difficult to treat infections caused by bacteria, which constitutes a global challenge since it threatens human health (Bhattacharjee et al, 2022; Hart, 2004; A. A. Khan et al, 2021; Yougbaré et al, 2020).…”

Section: Introductionmentioning

confidence: 99%

Carbon dots: Types, preparation, and their boosted antibacterial activity by photoactivation. Current status and future perspectives

Lagos

García

Cuadrado

et al. 2023

WIREs Nanomed Nanobiotechnol

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Carbon dots (CDs) correspond to carbon‐based materials (CBM) with sizes usually below 10 nm. These nanomaterials exhibit attractive properties such us low toxicity, good stability, and high conductivity, which have promoted their thorough study over the past two decades. The current review describes four types of CDs: carbon quantum dots (CQDs), graphene quantum dots (GQDs), carbon nanodots (CNDs), and carbonized polymers dots (CPDs), together with the state of the art of the main routes for their preparation, either by “top‐down” or “bottom‐up” approaches. Moreover, among the various usages of CDs within biomedicine, we have focused on their application as a novel class of broad‐spectrum antibacterial agents, concretely, owing their photoactivation capability that triggers an enhanced antibacterial property. Our work presents the recent advances in this field addressing CDs, their composites and hybrids, applied as photosensitizers (PS), and photothermal agents (PA) within antibacterial strategies such as photodynamic therapy (PDT), photothermal therapy (PTT), and synchronic PDT/PTT. Furthermore, we discuss the prospects for the possible future development of large‐scale preparation of CDs, and the potential for these nanomaterials to be employed in applications to combat other pathogens harmful to human health. This article is categorized under: Therapeutic Approaches and Drug Discovery > Nanomedicine for Infectious Disease

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Section: Introductionmentioning

confidence: 99%

Carbon dots: Types, preparation, and their boosted antibacterial activity by photoactivation. Current status and future perspectives

Lagos

García

Cuadrado

et al. 2023

WIREs Nanomed Nanobiotechnol

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“…coli and L. innocua, achieving about 6 log cfu reduction within only 5 min of contact and demonstrating significantly stronger killing efficiency than those of previously reported antimicrobial hydrogels. − …”

Section: Resultsmentioning

confidence: 81%

Soybean Protein Isolate-Incorporated Zwitterionic Hydrogel with Rapid Chlorine Rechargeable Biocidal and Antifouling Functions

Dong

2023

ACS Sustainable Chem. Eng.

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Pathogenic contamination is recognized as a significant burden on public health. Most current antimicrobial strategies are limited due to the irreversible consumption of antimicrobial agents and the biofouling effect. Herein, we reported a scalable approach of chemically incorporating soybean protein isolates (SPIs) into a zwitterionic (SBMA) hydrogel network. Benefiting from the existence of SPI moieties, the obtained SPI-SBMA hydrogels exhibit a high active chlorine capacity (>400 ppm), easy chlorine rechargeability, and long-term chlorine stability, ensuring a promising biocidal activity against both bacteria (6 log cfu reduction within 5 min) and viruses. SBMA moieties with robust hydration ability offer the SPI-SBMA hydrogel great antifouling functions, allowing the hydrogel to resist bacterial adhesion effectively and release attached bacteria quickly. The influence of SPI on the antifouling performance of SPI-SBMA hydrogel is a balance between the decreased hydrophilicity and reduced hydrogel channel size. The successfully synthesized SPI-SBMA hydrogel with intriguing biocidal and antifouling functions demonstrates good mechanical performance, implying great application potential in various areas.

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“…4.10. Biofilm disruption assay 33,48 Crystal violet staining. The biofilm disruption efficacy was investigated against the established biofilms formed by MRSA R3545 and VRSA 4 clinical isolates.…”

Section: Morphology Of the Hydrogelmentioning

confidence: 99%

Biocide loaded shear-thinning hydrogel with anti-biofilm efficacy cures topical infection

et al. 2023

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An easy-to-use antimicrobial hydrogel effectively kills bacteria, fungi, and influenza virus

Abstract: An easily administrable hydrogel is developed to take care of bacterial, fungal and viral infection.

Cited by 13 publications

References 38 publications

Carbon dots: Types, preparation, and their boosted antibacterial activity by photoactivation. Current status and future perspectives

Carbon dots: Types, preparation, and their boosted antibacterial activity by photoactivation. Current status and future perspectives

Soybean Protein Isolate-Incorporated Zwitterionic Hydrogel with Rapid Chlorine Rechargeable Biocidal and Antifouling Functions

Biocide loaded shear-thinning hydrogel with anti-biofilm efficacy cures topical infection

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